Definition: thalassemia due to one of two or more genes that depress (severely or moderately) synthesis of a-globin chains by the chromosome with the abnormal gene. Heterozygous state: severe type, thalassemia minor with 5–15% of Hb Bart at birth, only traces of Hb Bart in adult; mild type, 1–2% of Hb Bart at birth, not detectable in adult. Homozygous state: severe type, erythroblastosis fetalis and fetal death, only Hb Bart and Hb H present; mild type not clinically defined.
See Also: hemoglobin H
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Examples: glitazone, GI cocktail, etc.