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Medical Term:

a-ketoglutarate dehydrogenase


an enzyme that catalyzes the oxidative decarboxylation of 2-ketoglutaric acid to succinyldihydrolipoate; the succinyl group is later transferred to CoA and the reduced lipoate is oxidized by NAD+; a complex that is a part of the tricarboxylic acid cycle.

Synonym(s): 2-oxoglutarate dehydrogenase, a-ketoglutarate dehydrogenase complex

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