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a-ketodecarboxylase

Pronunciation: ke'to-de'kar-boks'i-las

Definition: Formerly, the enzyme system converting pyruvate (a 2-oxoacid) to acetyl-CoA and CO2, with reduction of NAD+ to NADH and the participation of lipoamide and thiamin pyrophosphate; now known to involve at least three enzymes in succession: pyruvate dehydrogenase, dihydrolipoamide acetyltransferase, and dihydrolipoamide dehydrogenase.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.

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