Skip to Content
Medical Term:


Pronunciation: ke'to-de'kar-boks'i-las

Definition: Formerly, the enzyme system converting pyruvate (a 2-oxoacid) to acetyl-CoA and CO2, with reduction of NAD+ to NADH and the participation of lipoamide and thiamin pyrophosphate; now known to involve at least three enzymes in succession: pyruvate dehydrogenase, dihydrolipoamide acetyltransferase, and dihydrolipoamide dehydrogenase.

© Copyright 2016 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.