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Pronunciation: ok'ko-pro'len

Definition: A keto derivative of proline that is formed nonenzymatically from glutamate, glutamine, and ?-glutamylated peptides; it is also produced by the action of ?-glutamylcyclotransferase; elevated levels of 5-oxoproline are often associated with problems of glutamine or glutathione metabolism.

Synonym(s): 5-pyrrolidone-2-carboxylic acid, pyroglutamic acid, pyrrolidone-5-carboxylate

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.