Definition: A keto derivative of proline that is formed nonenzymatically from glutamate, glutamine, and ?-glutamylated peptides; it is also produced by the action of ?-glutamylcyclotransferase; elevated levels of 5-oxoproline are often associated with problems of glutamine or glutathione metabolism.
Synonym(s): 5-pyrrolidone-2-carboxylic acid, pyroglutamic acid, pyrrolidone-5-carboxylate
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Examples: glitazone, GI cocktail, etc.
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