- a flavoenzyme that catalyzes the conversion of 4-hydroxyproline to ?'-pyrroline-3-hydroxy-5-carboxylate using FAD; this enzyme appears to be deficient in people with hyperhydroxyprolinemia;
- an enzyme that catalyzes the reaction of 4-hydroxyproline with NAD+ to form NADH and 4-oxoproline.
Synonym(s): 4-oxoproline reductase
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