Pronunciation: pir'o-len-kar-boks'i-lat de-hi'dro'gen-as
Definition: An enzyme that catalyzes the reversible reaction of 1-pyrroline 5-carboxylate and NAD+ to form l-glutamate and NADH; this enzyme plays a role in proline and ornithine metabolism; 1-pyrroline 5-carboxylate is in equilibrium with glutamate ?-semialdehyde; a deficiency of this enzyme is associated with type II hyperprolinemia.
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Examples: glitazone, GI cocktail, etc.