Generic Name: dolutegravir (Oral route)
Medically reviewed by Drugs.com. Last updated on Sep 9, 2019.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Antiretroviral Agent
Pharmacologic Class: Dolutegravir
Uses for Tivicay
Dolutegravir is used together with other medicines for the treatment of the infection caused by human immunodeficiency virus (HIV). HIV is the virus that causes acquired immune deficiency syndrome (AIDS). It is also used together with rilpivirine in adults to replace their current anti-HIV medicines when their healthcare provider determines that they meet certain requirements.
Dolutegravir will not cure or prevent HIV infection or AIDS, however, it helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay the development of problems that usually result from AIDS or HIV disease. Dolutegravir will not keep you from spreading HIV to other people. People who receive this medicine may continue to have some of the problems usually related to AIDS or HIV disease.
This medicine is available only with your doctor's prescription.
Before using Tivicay
Appropriate studies have not been performed on the relationship of age to the effects of dolutegravir in children weighing less than 30 kilograms. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dolutegravir in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution for patients receiving dolutegravir.
Interactions with medicines
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Eslicarbazepine Acetate
- St John's Wort
Interactions with food/tobacco/alcohol
Other medical problems
- Hepatitis B or C, or history of—Use with caution. May make this condition worse.
- Infections—May decrease your body's ability to fight infection.
- Liver disease, severe—Use is not recommended in patients with this condition.
Proper use of Tivicay
Use this medicine exactly as directed by your doctor. Do not take more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Also, do not change the dose or stop using this medicine without checking first with your doctor. When your supply of this medicine is running low, contact your doctor or pharmacist ahead of time. Do not allow yourself to run out of this medicine.
This medicine comes with a patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions.
Keep using dolutegravir for the full time of treatment, even if you begin to feel better. It is also important to take this medicine together with other medicines for HIV. Be sure to take all of the medicines your doctor ordered, and to take them at the right times.
You may take this medicine with or without food.
If you are taking antacids or laxatives containing aluminum, calcium, or magnesium, sucralfate, calcium or iron supplements, or buffered medicines, take dolutegravir at least 2 hours before or 6 hours after you take these medicines.
Alternatively, calcium or iron supplements may be taken together with this medicine if taken with food.
- For oral dosage form (tablets):
- For treatment of HIV infection:
- Adults—50 milligrams (mg) once a day. If you are taking or have received certain other HIV medicines, take 50 mg 2 times a day.
- Children weighing 40 kilograms (kg) or more—50 milligrams (mg) once a day.
- Children weighing 30 to less than 40 kg—35 mg once a day (one 25 mg tablet and one 10 mg tablet).
- Children weighing less than 30 kg—Use and dose must be determined by your doctor.
- For treatment of HIV infection:
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Store the medicine in its original bottle. Keep it tightly closed and protect from moisture.
Precautions while using Tivicay
It is very important that your doctor check your or your child's progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.
You should not use this medicine together with dofetilide (Tikosyn®). Using these medicines together may cause serious or life-threatening side effects.
It is important to tell your doctor if you are pregnant or planning to become pregnant before using this medicine. Using this medicine while you are pregnant can harm your unborn baby. Do not use this medicine during the first part of your pregnancy unless your doctor tells you to.
Serious skin and allergic reactions may occur while taking this medicine. Check with your doctor right away if you or your child have the following symptoms: a severe rash or rash with fever, blistering or peeling skin, joint or muscle pain, sores in the mouth, swelling of the face, trouble breathing, unusual tiredness or weakness, or yellow eyes or skin.
Your immune system may get stronger when you start taking HIV medicines. Tell your doctor right away if you or your child notices any changes in your health. Sometimes the immune system will start to fight infections that were hidden in your body, such as pneumonia or tuberculosis. Autoimmune disorders (eg, Graves' disease, polymyositis, or Guillain-Barré syndrome) may also occur.
This medicine will not keep you from giving HIV to your partner during sex. Make sure you understand this and practice safe sex, even if your partner also has HIV, by using a latex condom or other barrier method. This medicine will also not keep you from giving HIV to other people if they are exposed to your blood. Do not re-use or share needles with anyone.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.
Tivicay side effects
Check with your doctor immediately if any of the following side effects occur:
- Black, tarry stools
- blistering or peeling skin
- bloody urine
- burning, dry, or itching eyes
- chest pain
- dark urine
- decreased frequency or amount of urine
- discharge or excessive tearing
- general feeling of discomfort or illness
- general feeling of tiredness and weakness
- increased thirst
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
- light-colored stools
- loss of appetite
- lower back or side pain
- muscle or joint aches
- painful or difficult urination
- rash with fever
- redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
- severe rash
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- swelling of the face, fingers, feet, or lower legs
- swollen glands
- troubled breathing
- unusual bleeding or bruising
- unusual tiredness or weakness
- upper right abdominal or stomach pain
- weight gain
- yellow eyes and skin
Incidence not known
- Clay-colored stools
- decreased appetite
- stomach pain or tenderness
- Itching skin
- stomach discomfort
- trouble sleeping
- Abnormal dreams
Incidence not known
- difficulty in moving
- joint pain or swelling
- muscle cramp or stiffness
Copyright 2020 Truven Health Analytics, Inc. All Rights Reserved.
More about Tivicay (dolutegravir)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- 16 Reviews
- Drug class: integrase strand transfer inhibitor
- FDA Alerts (1)
- FDA Approval History