Generic Name: pasireotide (Subcutaneous route, Intramuscular route)
Medically reviewed by Drugs.com. Last updated on Oct 25, 2019.
Commonly used brand name(s)
In the U.S.
- Signifor LAR
Available Dosage Forms:
- Powder for Suspension
Therapeutic Class: Endocrine-Metabolic Agent
Pharmacologic Class: Somatostatin (class)
Uses for Signifor
Pasireotide injection is used to treat Cushing's disease in adults who cannot have surgery or have failed surgery.
Pasireotide injection is also used for the treatment of acromegaly (a growth hormone disorder) in patients who cannot be treated with surgery.
Signifor® is available only with your doctor's prescription. Signifor® LAR is given only by or under the direct supervision of your doctor.
Before using Signifor
Appropriate studies have not been performed on the relationship of age to the effects of the pasireotide injection in the pediatric population. Safety and efficacy have not been demonstrated.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pasireotide injection in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving pasireotide injection.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Gallium Ga 68 Dotatate
- Gallium Ga 68 Dotatoc
- Inotuzumab Ozogamicin
- Insulin Aspart, Recombinant
- Insulin Bovine
- Insulin Degludec
- Insulin Detemir
- Insulin Glargine, Recombinant
- Insulin Glulisine
- Insulin Lispro, Recombinant
- Lutetium Lu 177 Dotatate
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
Interactions with food/tobacco/alcohol
Other medical problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Adrenal problems or
- Gallbladder disease or
- Gallstones, or history of or
- Heart disease or
- Heart rhythm problem (eg, QT prolongation)—Use with caution. May make these conditions worse.
- Angina (severe chest pain), unstable or
- Bradycardia (slow heartbeat), history of or
- Congestive heart failure, not properly controlled or
- Heart attack, recent or
- Heart block, history of or
- Heart rhythm problem (eg, congenital long QT prolongation) or
- Hypokalemia (low potassium in the blood) or
- Hypomagnesemia (low magnesium in the blood)—May increase risk for more serious side effects.
- Diabetes, poorly controlled or
- Hyperglycemia (high blood sugar)—Should be treated first before using this medicine.
- Liver disease, moderate—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Proper use of Signifor
This section provides information on the proper use of a number of products that contain pasireotide. It may not be specific to Signifor. Please read with care.
Signifor® is given as a shot under your skin, usually on the thigh or the abdomen (stomach). Signifor® LAR is given as a shot into a muscle, usually in the buttocks.
A nurse or other trained health professional may give you this medicine. It may also be given at home by patients who do not need to be in the hospital or clinic. If you are using this medicine at home, your doctor or nurse will teach you how to prepare and inject the medicine. Be sure that you understand how to use the medicine.
This medicine should come with a Medication Guide and patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.
You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.
Use a new needle and syringe each time you inject your medicine. Do not reuse needles and syringes.
You might not use all of the medicine in each ampul (glass container). Do not save an opened ampul. If the medicine in the ampul has changed color, or if you see particles in it, do not use it.
- For injection dosage form:
- For treatment of Cushing's disease:
- Adults—At first, 0.6 or 0.9 milligram (mg) injected under the skin 2 times a day. Your doctor will adjust your dose as needed and tolerated.
- Children—Use and dose must be determined by your doctor.
- For treatment of Cushing's disease:
If you miss a dose of Signifor® LAR you may receive your missed dose up to 14 days before your next dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.
Precautions while using Signifor
It is very important that your doctor check you closely while you are receiving this medicine. This is to make sure that this medicine is working properly. Blood tests, electrocardiogram (ECG), and gallbladder ultrasound may be needed to check your progress.
This medicine may cause low levels of cortisol in the blood (hypocortisolism). Tell your doctor right away if you have confusion, weakness, loss of appetite, nausea or vomiting, lightheadedness, dizziness, or fainting.
This medicine may raise your blood sugar. You should check your blood sugar more often during the first 2 to 3 months of using this medicine, and then on a regular basis.
Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a slow, fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.
This medicine may cause gallstones, which can lead to swelling of the gallbladder (cholecystitis) or bile ducts (cholangitis). Check with your doctor right away if you have severe stomach pain with nausea and vomiting, indigestion, fever, chills, or yellow eyes or skin.
Check with your doctor right away if you have more than one of these symptoms while you are using this medicine: darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting.
This medicine may improve fertility in women and may cause unwanted pregnancies. Talk to your doctor if you have concerns.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Signifor side effects
Check with your doctor immediately if any of the following side effects occur:
- bloating or swelling of the face, arms, hands, lower legs, or feet
- blurred vision
- cold sweat
- cool, pale skin
- darkening of the skin
- decreased urine
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- dry mouth
- flushed, dry skin
- fruit-like breath odor
- gaseous abdominal or stomach pain
- increased hunger
- increased thirst
- increased urination
- irregular heartbeat
- loss of appetite
- loss of consciousness
- muscle pain or cramps
- numbness or tingling in the hands, feet, or lips
- pounding in the ears
- rapid weight gain
- recurrent fever
- skin rash
- slow or fast heartbeat
- slurred speech
- stomach pain or fullness
- tingling of the hands or feet
- troubled breathing
- unexplained weight loss
- unusual tiredness or weakness
- unusual weight gain or loss
- upper abdominal or stomach pain
- yellow eyes or skin
Incidence not known
- Clay-colored stools
- darkened urine
- dry skin and hair
- feeling cold
- hair loss
- hoarseness or husky voice
- loss of appetite
- muscle stiffness
- pains in the stomach, side, or abdomen, possibly radiating to the back
- severe nausea or vomiting
- unpleasant breath odor
- vomiting of blood
- weight gain
- Back pain
- bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- decreased appetite
- difficulty with moving
- feeling of constant movement of self or surroundings
- general feeling of discomfort or illness
- joint pain
- lack or loss of strength
- pain in the arms or legs
- pressure in the stomach
- sensation of spinning
- stuffy or runny nose
- swelling of the abdominal or stomach area
- swollen joints
- trouble sleeping
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More about Signifor (pasireotide)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: somatostatin and somatostatin analogs
- FDA Approval History
Other brands: Signifor LAR