paclitaxel protein-bound (Intravenous route)
pak-li-TAX-el PROE-teen - bownd
Do not administer paclitaxel protein-bound particles for injectable suspension therapy to patients with baseline neutrophil counts less than 1500 cells/mm(3). Perform frequent peripheral blood counts to monitor the occurrence of bone marrow suppression. Do not substitute with other paclitaxel formulations .
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
- Powder for Suspension
Therapeutic Class: Antineoplastic Agent
Pharmacologic Class: Mitotic Inhibitor
Uses For paclitaxel protein-bound
Paclitaxel protein-bound injection is used to treat metastatic breast cancer (cancer that has already spread) after other treatments have failed. It is used together with carboplatin, a cancer medicine, to treat advanced or metastatic non-small cell lung cancer in patients who cannot receive radiation therapy or have surgery. Paclitaxel protein-bound is used together with gemcitabine, a cancer medicine, to treat metastatic pancreas cancer.
Paclitaxel belongs to the group of medicines called antineoplastics (cancer medicines). It interferes with the growth of cancer cells, which are eventually destroyed by the body. Since the growth of normal body cells may also be affected by paclitaxel, other unwanted effects will also occur.
paclitaxel protein-bound is to be given only by or under the direct supervision of a doctor.
Before Using paclitaxel protein-bound
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For paclitaxel protein-bound, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to paclitaxel protein-bound or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of paclitaxel protein-bound injection in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of paclitaxel protein-bound injection in the elderly. However, elderly patients are more likely to have unwanted effects which may require caution in patients receiving paclitaxel protein-bound.
|All Trimesters||D||Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving paclitaxel protein-bound, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using paclitaxel protein-bound with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Measles Virus Vaccine, Live
- Mumps Virus Vaccine, Live
- Rotavirus Vaccine, Live
- Rubella Virus Vaccine, Live
- Varicella Virus Vaccine
Using paclitaxel protein-bound with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Adenovirus Vaccine
- Bacillus of Calmette and Guerin Vaccine, Live
- Cholera Vaccine, Live
- Ethinyl Estradiol
- Influenza Virus Vaccine, Live
- Poliovirus Vaccine, Live
- Smallpox Vaccine
- Typhoid Vaccine
- Yellow Fever Vaccine
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of paclitaxel protein-bound. Make sure you tell your doctor if you have any other medical problems, especially:
- Infection—May decrease body's ability to fight infection.
- Liver disease, moderate to severe—Should not be used to treat pancreas cancer in patients with this condition.
- Neutropenia (low white blood cells) or
- Sensory neuropathy (tingling, numbness of arms, hands, legs, or feet)—Use with caution. May make these conditions worse.
Proper Use of paclitaxel protein-bound
You will receive paclitaxel protein-bound while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you paclitaxel protein-bound. paclitaxel protein-bound is given through a needle placed in one of your veins.
paclitaxel protein-bound comes with a patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions.
Precautions While Using paclitaxel protein-bound
It is very important that your doctor check your progress at regular visits to make sure paclitaxel protein-bound is working properly. Blood tests may be needed to check for unwanted effects.
Using paclitaxel protein-bound while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
Men who are receiving paclitaxel protein-bound should not father a child. paclitaxel protein-bound can harm the unborn baby of your partner.
paclitaxel protein-bound may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are receiving paclitaxel protein-bound.
Paclitaxel can temporarily lower the number of white blood cells in your blood, which will increase the chance of getting an infection. It can also lower the number of platelets in your blood, which are necessary for proper blood clotting. If this occurs, these are the precautions you can take to reduce the risk of infection or bleeding:
- If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection, or if you get a fever or chills, cough or hoarseness, lower back or side pain, or have painful or difficult urination.
- Check with your doctor immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in your urine or stools, or pinpoint red spots on your skin.
- Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.
- Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
- Be careful not to cut yourself when you are using sharp objects, such as a safety razor, fingernail clippers, or toenail clippers.
- Avoid contact sports or other situations where bruising or injury could occur.
paclitaxel protein-bound is made from donated human blood. Although the risk is low, some people have received viruses from human blood products. Human donors and donated blood are both tested for viruses before the medicine is prepared. Talk with your doctor if this concerns you.
Check with your doctor right away if you have burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. These could be symptoms of a condition called sensory neuropathy.
Lung or breathing problems may occur if you are receiving paclitaxel protein-bound together with gemcitabine. Tell your doctor right away if you have shortness of breath, trouble breathing, or a persistent dry cough.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
paclitaxel protein-bound Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:More common
- Black, tarry stools
- bloating or swelling of the face, arms, hands, lower legs, or feet
- blurred or double vision
- chest pain
- loss of taste
- lower back or side pain
- painful or difficult urination
- pale skin
- rapid weight gain
- sore mouth, tongue, or throat
- tightness in the chest
- tingling of the hands or feet
- troubled breathing with exertion
- ulcers, sores, or white spots in the mouth
- unusual bleeding or bruising
- unusual weight gain or loss
- unusual tiredness or weakness
- blood in the urine or stools
- burning, tingling, numbness or pain in the hands, arms, feet, or legs
- difficulty with swallowing
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast, pounding, slow, or irregular heartbeat or pulse
- general feeling of discomfort or illness
- inability to move the arms, legs, or facial muscles
- inability to speak
- pain in the chest, groin, or legs, especially the calves
- pinpoint red spots on the skin
- rapid, shallow breathing
- sensation of pins and needles
- severe, sudden headache
- skin itching, rash, or redness
- slurred or slow speech
- stabbing pain
- sudden loss of coordination
- sudden, severe weakness or numbness in the arms or legs
- sudden, unexplained shortness of breath
- swelling of the face, throat, or tongue
- thickening of bronchial secretions
- trouble thinking or walking
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Cracked lips
- decreased appetite
- difficulty with moving
- lack or loss of strength
- loss of hair
- muscle pain or stiffness
- pain in the joints
- Bleeding, blistering, burning, coldness, discoloration of the skin, a feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- Nail changes
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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More about paclitaxel protein-bound
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
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- Drug class: mitotic inhibitors
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