nepafenac (Ophthalmic route)
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Anti-Inflammatory
Pharmacologic Class: NSAID
Uses For nepafenac
Nepafenac eye drops is used to treat pain and swelling of the eye following cataract surgery. nepafenac is a topical nonsteroidal anti-inflammatory drug (NSAID).
nepafenac is available only with your doctor's prescription.
Before Using nepafenac
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For nepafenac, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to nepafenac or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of nepafenac eye drops in children younger than 10 years of age. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of nepafenac eye drops in the elderly.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking nepafenac, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using nepafenac with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using nepafenac with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Amtolmetin Guacil
- Beta Glucan
- Bismuth Subsalicylate
- Choline Magnesium Trisalicylate
- Choline Salicylate
- Dabigatran Etexilate
- Ethacrynic Acid
- Flufenamic Acid
- Magnesium Salicylate
- Mefenamic Acid
- Niflumic Acid
- Nimesulide Beta Cyclodextrin
- Pentosan Polysulfate Sodium
- Phenyl Salicylate
- Protein C
- Salicylic Acid
- Sodium Salicylate
- Tiaprofenic Acid
- Tolfenamic Acid
- Trolamine Salicylate
Using nepafenac with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Azilsartan Medoxomil
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of nepafenac. Make sure you tell your doctor if you have any other medical problems, especially:
- Allergy to NSAIDs (eg, aspirin, celecoxib, diclofenac, etodolac, ibuprofen, indomethacin, nabumetone, naproxen, piroxicam, rofecoxib, valdecoxib, Advil®, Aleve®, Celebrex®, Ecotrin®, Motrin®, Voltaren®), history of—Should not be used in patients with this condition.
- Bleeding problems—Use with caution. May make this condition worse.
- Corneal (front part of the eye) denervation or
- Corneal (front part of the eye) epithelial defects or
- Diabetes or
- Ocular (eye) surface diseases (eg, dry eye syndrome) or
- Ocular (eye) surgeries, complicated or
- Ocular (eye) surgeries, multiple within a short period of time or
- Rheumatoid arthritis—Use with caution. May increase the risk of having serious eye problems.
Proper Use of nepafenac
Your eye doctor will tell you how much of nepafenac to use and how often. Do not use more medicine or use it more often than your doctor tells you to. nepafenac is not for long-term use.
Keep using nepafenac for at least 2 weeks unless your doctor tells you otherwise.
nepafenac can be used with other eye medicines. Wait at least 5 minutes before using another eye medicine.
If you or your child are wearing contact lenses, remove them while you are using nepafenac. Talk to your eye doctor about this if you have questions.
To use the eye drops:
- Shake the bottle well before each use.
- First, wash your hands. Tilt the head back and, pressing your finger gently on the skin just beneath the lower eyelid away from the eye to make a space. Drop the medicine into this space. Let go of the eyelid and gently close the eyes. Do not blink. Keep the eyes closed and apply pressure to the inner corner of the eye with your finger for 1 or 2 minutes to allow the medicine to be absorbed by the eye.
- Immediately after using the eye drops, wash your hands to remove any medicine that may be on them.
- To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, always keep the container tightly closed. Serious damage to the eye and possible loss of vision may result from using contaminated eye drops.
The dose of nepafenac will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of nepafenac. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For ophthalmic dosage form (eye drops):
- For eye pain or swelling following cataract surgery:
- Adults, teenagers, and children 10 years of age and older—
- Ilevro™: Use one drop in the affected eye once a day beginning 1 day before cataract surgery, continued on the day of surgery, and for 2 weeks after the surgery. An additional drop should be given 30 to 120 minutes before surgery.
- Nevanac®: Use one drop in the affected eye three times a day beginning 1 day before cataract surgery, continued on the day of surgery, and for 2 weeks after the surgery.
- Children younger than 10 years of age—Use and dose must be determined by your doctor.
- Adults, teenagers, and children 10 years of age and older—
- For eye pain or swelling following cataract surgery:
If you miss a dose of nepafenac, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions While Using nepafenac
Your eye doctor will check your or your child's eyes at regular visits to make sure it is working properly and is not causing unwanted effects.
If your or your child's symptoms do not improve within a few days or if they become worse, check with your doctor.
Slow or delayed healing may occur while you or your child are using nepafenac. Ask your doctor before using nepafenac together with a topical corticosteroid (eg, betamethasone, hydrocortisone).
Using nepafenac may increase risk of having corneal (front part of the eye) problems, including keratitis. Check with your eye doctor right away if you or your child have blurred vision, changes in vision, or eye redness, irritation, or pain while using nepafenac.
Make sure your doctor knows if you are pregnant. Do not use nepafenac during the later part of a pregnancy, unless your doctor tells you to.
If you hurt your eye or develop an eye infection, talk with your doctor right away. You may need to change your medicine or stop using it.
Do not use other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
nepafenac Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:More common
- Blurred vision
- change in vision
- decrease in vision
- loss of vision
- Eye pain
- itching of the eye
- swelling and/or redness of the eye and lining of the eyelid
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Feeling of having something in the eye
- sticky sensation of the eyelids
- Change in color vision
- crusting in the corner of the eye
- difficulty seeing at night
- dry eyes
- increased sensitivity of the eyes to sunlight
- nausea or vomiting
- pounding in the ears
- seeing flashes or sparks of light
- seeing floating spots before the eyes, or a veil or curtain appearing across part of vision
- slow or fast heartbeat
- stuffy or runny nose
- tenderness around the eyes and cheekbones
- tightness of the chest or wheezing
- troubled breathing
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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More about nepafenac ophthalmic
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
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- Drug class: ophthalmic anti-inflammatory agents