Generic Name: naloxegol (Oral route)
Medically reviewed on Oct 31, 2018
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Pharmacologic Class: Opioid Antagonist
Uses For Movantik
Naloxegol is used to treat constipation that is caused by opioids (narcotic pain medicines) in adults with long-lasting pain that is not caused by cancer, or in patients with long-lasting pain caused by a previous cancer or its treatment who do not need weekly increases in opioid dosage.
This medicine is available only with your doctor's prescription.
Before Using Movantik
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of naloxegol in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of naloxegol in the elderly. However, elderly patients are more sensitive to the effects of this medicine than younger adults.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- St John's Wort
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
- Grapefruit Juice
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Crohn's disease or
- Diverticulitis or
- Severe Liver Disease or
- Ogilvie's syndrome or
- Peptic ulcer or
- Stomach or bowel cancer—May increase risk for more serious side effects.
- Kidney disease, moderate to severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
- Patients at increased risk of stomach blockage or
- Stomach or bowel blockage, known or suspected—Should not be used in patients with these conditions.
Proper Use of Movantik
Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.
This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.
Take this medicine on an empty stomach at least 1 hour before the first meal of the day or 2 hours after a meal.
Swallow the tablet whole. Do not crush, break, or chew it.
Stop taking other laxatives before starting treatment with naloxegol. Also, you should stop taking naloxegol if you have stopped taking narcotic pain medicines.
If you have trouble swallowing the tablet, you may crush and mix it with 120 milliliters (mL) (4 ounces) of water and drink it right away. Refill the glass with the same amount of water, stir, and drink it right away to make sure you get the full dose of this medicine.
If you have trouble swallowing the tablet, it may also be given through a nasogastric tube:
- Draw up 30 mL (1 ounce) of water into a 60 mL syringe and flush it down the nasogastric tube.
- Crush the tablet and mix it with 60 mL (2 ounces) of water.
- Draw up the mixture using the 60 mL syringe and give it through the tube.
- Add 60 mL of water to the mixture and use the same syringe to flush the tube for any remaining medicine to get the full dose of this medicine.
Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (tablets):
- For constipation caused by opioids:
- Adults—25 milligrams (mg) once a day in the morning for at least 4 weeks (together with narcotic pain medicines). Your doctor may adjust your dose as needed.
- Children—The safety and effectiveness of Movantik has not been established in children.
- For constipation caused by opioids:
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions While Using Movantik
It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.
Do not take this medicine together with clarithromycin, itraconazole, or ketoconazole. Using these medicines together may cause or worsen opioid withdrawal symptoms, such as anxiety, chills, diarrhea, irritability, stomach pain, sweating, and yawning.
Call your doctor right away if you have severe stomach pain or diarrhea while you are using this medicine.
This medicine may cause a tear (perforation) in your stomach or bowels. Check with your doctor right away if you have a severe stomach pain that does not go away.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.
Movantik Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
- increased sweating
- stomach pain
Incidence not known
- severe abdominal or stomach pain, cramping, or burning
- trouble breathing
- vomiting of material that looks like coffee grounds, severe and continuous
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Abdominal pain
- excess air or gas in the stomach or bowels
- full feeling
- passing of gas
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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- Drug class: peripheral opioid receptor antagonists