Generic Name: prucalopride (Oral route)
Medically reviewed by Drugs.com. Last updated on Aug 8, 2019.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Stimulant, Gastrointestinal
Pharmacologic Class: Serotonin Receptor Agonist, 5-HT4
Uses for Motegrity
Prucalopride is used to treat chronic idiopathic (unknown cause) constipation (CIC). It works by increasing peristalsis (contractions) in the colon, leading to an increase in the number of bowel movements.
This medicine is available only with your doctor's prescription.
Before using Motegrity
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of prucalopride in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of prucalopride in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving prucalopride.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Interactions with food/tobacco/alcohol
Other medical problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Depression or other mood problems, or history of—Use with caution. May make this condition worse.
- Kidney disease, severe (eg, end-stage kidney disease)—Use with caution. The effects may be increased because of the slower removal of the medicine from the body.
- Stomach or bowel perforation (hole), blockage, or swelling (eg, obstructive ileus, Crohn’s disease, ulcerative colitis, toxic megacolon or megarectum)—Should not be used in patients with this condition.
Proper use of Motegrity
Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.
This medicine comes with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.
You may take this medicine with or without food.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
- For oral dosage form (tablets):
- For chronic idiopathic constipation:
- Adults—2 milligrams (mg) once a day.
- Children—Use and dose must be determined by your doctor.
- For chronic idiopathic constipation:
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Keep the medicine in its original container.
Precautions while using Motegrity
It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects.
This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. Make sure the doctor knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell the doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. If you or your caregiver notice any of these side effects, tell your doctor right away.
Motegrity side effects
Check with your doctor immediately if any of the following side effects occur:
- Frequent urination of small amounts of urine in the daytime
- headache, severe and throbbing
- Chest pain or discomfort
- difficulty in speaking
- double vision
- inability to move the arms, legs, or facial muscles
- inability to speak
- pain or discomfort in the arms, jaw, back, or neck
- slow speech
- thoughts or attempts at killing oneself
- troubled breathing
Incidence not known
- Hives or welts, itching, skin rash
- redness of the skin
- swelling of the face
- tightness in the chest
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- stomach pain
- Abnormal stomach or bowel sounds
- bloated or full feeling
- decreased appetite
- excess air or gas in the stomach or bowels
- passing gas
- stomach distension
- unusual tiredness or weakness
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More about Motegrity (prucalopride)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- 11 Reviews
- Drug class: serotoninergic neuroenteric modulators
- FDA Approval History