Medically reviewed by Drugs.com. Last updated on Sep 17, 2022.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Renal-Urologic Agent
Uses for lumasiran
Lumasiran injection is used to treat primary hyperoxaluria (high oxalic acid in the urine) type 1 (PH1) to lower oxalic acid in the urine and blood.
Lumasiran is to be given only by or under the supervision of your doctor.
Before using lumasiran
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For lumasiran, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to lumasiran or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of lumasiran injection in children. Safety and efficacy have been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of lumasiran injection in the elderly.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Proper use of lumasiran
A nurse or other trained health professional will give you lumasiran in a medical facility. It is given as a shot under your skin, usually in the stomach, thigh, or the side or back of the upper arms. For patients on dialysis: Lumasiran is given after receiving dialysis.
Call your doctor or pharmacist for instructions.
Precautions while using lumasiran
It is very important that your doctor check your progress at regular visits to make sure lumasiran is working properly to check for unwanted effects.
Lumasiran side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- stomach pain
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
More about lumasiran
- Side effects
- Dosage information
- During pregnancy
- Drug class: miscellaneous metabolic agents
- En español
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.