Clostridium difficile-associated diarrhea (CDAD) has been reported and may range in severity from mild to life-threatening. Colectomy has been required with some antibiotic-resistant CDAD infections, and clindamycin therapy has been associated with fatal colitis. CDAD onset may occur more than 2 months after cessation of antibiotics. Therefore, it is important to consider this diagnosis in patients who present with diarrhea after antibacterial treatment. Clindamycin should be reserved for serious infections where less toxic antimicrobial agents are inappropriate. Do not use clindamycin to treat nonbacterial infections (eg, most upper respiratory tract infections). Consider discontinuation of ongoing antibiotic treatment not directed against C difficile if CDAD is suspected or confirmed. Supportive treatment may include fluid and electrolyte management, protein supplementation, antibiotic treatment of C difficile, and surgical evaluation when clinically indicated .Intramuscular route(Solution)
Clostridium difficile-associated diarrhea (CDAD) has been reported and may range in severity from mild to life-threatening. Colectomy has been required with some antibiotic-resistant CDAD infections, and clindamycin therapy has been associated with fatal colitis. CDAD onset may occur more than 2 months after cessation of antibiotics. Therefore, it is important to consider this diagnosis in patients who present with diarrhea after antibacterial treatment. Clindamycin should be reserved for serious infections where less toxic antimicrobial agents are inappropriate. Do not use clindamycin to treat nonbacterial infections (eg, most upper respiratory tract infections). Consider discontinuation of ongoing antibiotic treatment not directed against C difficile if CDAD is suspected or confirmed. Supportive treatment may include fluid and electrolyte management, protein supplementation, antibiotic treatment of C difficile, and surgical evaluation when clinically indicated .
Medically reviewed on April 30, 2018.
Commonly used brand name(s)
In the U.S.
- Cleocin Phosphate IV
Available Dosage Forms:
Therapeutic Class: Antibiotic
Chemical Class: Lincosamide
Uses For This Medicine
Clindamycin injection is used to treat bacterial infections. Clindamycin is given to patients who had an allergic reaction to penicillin. Clindamycin injection will not work for colds, flu, or other virus infections.
Clindamycin is to be given only by or under the direct supervision of your doctor.
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For clindamycin, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to clindamycin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of clindamycin injection in children.
Although appropriate studies on the relationship of age to the effects of clindamycin injection have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have colitis, which may require caution in patients receiving clindamycin injection.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving clindamycin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using clindamycin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Cholera Vaccine, Live
Using clindamycin with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of clindamycin. Make sure you tell your doctor if you have any other medical problems, especially:
- Atopic syndrome or
- Diarrhea or
- Liver disease, severe or
- Stomach or bowel problems, history of—Use with caution. May make these conditions worse.
Proper Use of This Medicine
A nurse or other trained health professional will give you or your child clindamycin in a hospital. Clindamycin is given as a shot into a muscle or into a vein.
Your doctor will give you or your child a few doses of clindamycin until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.
Precautions While Using This Medicine
It is important that your doctor check your or your child's progress after treatment. This is to make sure that the infection is cleared up completely, and to allow your doctor to check for any unwanted effects. Blood tests may be needed to check for unwanted effects.
Clindamycin may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you or your child stop using clindamycin. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.
Serious skin reactions can occur with clindamycin. Check with your doctor right away if you or your child have blistering, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you or your child are receiving clindamycin.
Clindamycin may cause a serious allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you or your child are receiving clindamycin.
This Medicine Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:Rare
- Cracks in the skin
- loss of heat from the body
- red, swollen skin
- scaly skin
- Abdominal or stomach cramps, pain, or tenderness
- black, tarry stools
- bleeding gums
- blistering, peeling, or loosening of the skin
- blood in the urine or stools
- blurred vision
- chest pain
- clay-colored stools
- cloudy urine
- cough or hoarseness
- dark urine
- decrease in the amount of urine
- diarrhea, watery and severe, which may also be bloody
- difficulty with swallowing
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- dry mouth
- fast heartbeat
- fever with or without chills
- general feeling of tiredness or weakness
- heart stops
- hives or welts, itching, or skin rash
- increased thirst
- itching of the vagina or genital area
- joint or muscle pain
- loss of appetite
- lower back or side pain
- nausea or vomiting
- no breathing
- no pulse or blood pressure
- pain during sexual intercourse
- pain in the lower back or side
- pain, tenderness, or swelling of the foot or leg
- painful or difficult urination
- pinpoint red spots on the skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rash with flat lesions or small raised lesions on the skin
- red skin lesions, often with a purple center
- red, irritated eyes
- redness of the skin
- shortness of breath
- sore throat
- sores, ulcers, or white spots in the mouth or on the lips
- swollen glands
- thick, white vaginal discharge with no odor or with a mild odor
- tightness in the chest
- unpleasant breath odor
- unusual bleeding or bruising
- unusual tiredness or weakness
- unusual weight loss
- vomiting of blood
- yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Incidence not known
- Bitter taste
- changes in skin color
- pain, lump, or irritation at the injection site
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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