Bupivacaine liposome (Injection)
Medically reviewed on June 7, 2018
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Anesthetic, Local
Chemical Class: Amino Amide
Uses For This Medicine
Bupivacaine liposome injection is used to relieve pain after surgery. It is a local anesthetic that prevents pain by blocking signals at the nerve endings directly at the surgical area or by blocking nerve endings of the brachial plexus (nerves that conduct signals to the shoulder, arm, and hand).
Bupivacaine liposome is to be given only by or under the direct supervision of a doctor.
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For bupivacaine liposome, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to bupivacaine liposome or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of bupivacaine liposome injection in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of bupivacaine liposome injection in the elderly. However, elderly patients are more likely to have kidney problems, which may require caution for patients receiving bupivacaine liposome injection.
Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving bupivacaine liposome, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using bupivacaine liposome with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- St John's Wort
Using bupivacaine liposome with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Enalapril Maleate
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of bupivacaine liposome. Make sure you tell your doctor if you have any other medical problems, especially:
- Heart or blood vessel problems—May increase risk for more serious side effects.
- Kidney disease or
- Liver disease, moderate to severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Proper Use of This Medicine
A nurse or other trained health professional will give you bupivacaine liposome in a hospital. It is given through a needle injected into the tissue at the surgical site (eg, foot) or into the nerve endings of the brachial plexus (nerves that conduct signals to the shoulder, arm, and hand).
Bupivacaine liposome should cause numbness only to the area where it is injected. You may experience temporary loss of sensation or movement to the injected area for up to 5 days. This type of numbing procedure is called local anesthesia. It is not meant to cause you to fall asleep or become unconscious.
Bupivacaine liposome injection (Exparel®) works differently than other forms of bupivacaine, even at the same dose. You should not receive another type of bupivacaine injection or another anesthetic within 4 days (96 hours) after the injection of Exparel®.
Precautions While Using This Medicine
It is very important that your doctor check your progress closely after you receive bupivacaine liposome. This will allow your doctor to see if the medicine is working properly and to check for any unwanted effects.
Bupivacaine liposome should not be given to women during labor (obstetrical paracervical block anesthesia).
Tell your doctor or nurse right away if you have the following symptoms with bupivacaine liposome: anxiety, blurred vision, depression, drowsiness, lightheadedness, nausea or vomiting, numbness and tingling of the mouth or lips, restlessness, ringing in the ears, speech problems, or tremors.
Bupivacaine liposome may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth, or throat after receiving bupivacaine liposome.
Bupivacaine liposome may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how bupivacaine liposome affects you.
Bupivacaine liposome may also increase your risk of having serious heart and blood vessel problems such as a heart attack, heart rhythm changes, or low blood pressure. Check with your doctor if you have chest pain or discomfort, pain or discomfort in the arms, jaw, back, or neck, dizziness, fainting, pounding, slow heartbeat, troubled breathing, or unusual tiredness or weakness.
Check with your doctor if you have joint pain, stiffness, or loss of motion of the shoulder. This may be symptoms of a serious bone or joint problem called chondrolysis.
This Medicine Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
- Blurred vision
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast, pounding, or irregular heartbeat or pulse
- Bloating or swelling of the face, arms, hands, lower legs, or feet
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- collection of blood under the skin
- decrease in frequency of urination
- decrease in urine volume
- deep, dark purple bruise
- difficulty in passing urine (dribbling)
- dry mouth
- increased thirst
- irregular heartbeat
- itching, pain, redness, or swelling
- loss of appetite
- mood changes
- muscle pain, cramp, or twitching
- painful urination
- pale skin
- pounding in the ears
- rapid weight gain
- slow or fast heartbeat
- tingling of the hands or feet
- trouble breathing
- trouble breathing with exertion
- unusual bleeding or bruising
- unusual weight gain or loss
Incidence not known
- Chest pain or discomfort
- loss of consciousness
- no blood pressure or pulse
- stopping of the heart
- weakness of the muscles in your face
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Motor dysfunction
- trouble sleeping
- change in taste
- decreased appetite
- feeling hot
- itching in the genitals or other skin areas
- loss of taste
- sensory loss
- stomach discomfort, upset, or pain
- swelling at the surgical site
- Increased sweating
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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More about bupivacaine liposome
- Bupivacaine liposome Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Español
- 9 Reviews – Add your own review/rating
- Drug class: local injectable anesthetics
Other brands: Exparel