argatroban (Intravenous route)Pronunciation
Available Dosage Forms:
Therapeutic Class: Anticoagulant
Pharmacologic Class: Thrombin Inhibitor, Direct
Uses For argatroban
Argatroban is used to decrease the clotting ability of the blood and to help prevent harmful clots from forming in the blood vessels. argatroban is used to treat or prevent blood clots in patients with bleeding problems caused by another medicine called heparin. It may also be used in patients who are having certain heart and blood vessel procedures, such as coronary angioplasty.
argatroban is available only with your doctor's prescription.
Before Using argatroban
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For argatroban, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to argatroban or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of argatroban in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of argatroban in the elderly. However, elderly patients are more likely to have age-related liver problems, which may require an adjustment of dosage in patients receiving argatroban.
|All Trimesters||B||Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving argatroban, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using argatroban with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Alipogene Tiparvovec
- Alteplase, Recombinant
- Amtolmetin Guacil
- Choline Salicylate
- Collagenase, Clostridium histolyticum
- Dabigatran Etexilate
- Drotrecogin Alfa
- Flufenamic Acid
- Ibuprofen Lysine
- Mefenamic Acid
- Niflumic Acid
- Pentosan Polysulfate Sodium
- Propionic Acid
- Reteplase, Recombinant
- Salicylic Acid
- Sodium Salicylate
- Tiaprofenic Acid
- Tolfenamic Acid
Using argatroban with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Vitamin A
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of argatroban. Make sure you tell your doctor if you have any other medical problems, especially:
- Bleeding, active—Should not be used in patients with this condition.
- Blood disease or bleeding problems or
- High blood pressure, severe or
- Major surgery (e.g., eye, brain, or spine surgery) or
- Spinal anesthesia or lumbar puncture or
- Stomach or intestinal ulcer—Use with caution. The risk of bleeding may be increased.
- Liver disease—Effects may be increased because of slower removal of the medicine from the body.
Proper Use of argatroban
A nurse or other trained health professional will give you argatroban. argatroban is given through a needle placed into one of your veins.
Precautions While Using argatroban
argatroban will only be given to you while you are in the hospital. Before you leave the hospital, you may be switched to an oral medicine that works in a similar way. If you have any concerns about this, talk to your doctor.
It is very important that your doctor check you at regular visits after you leave the hospital for any problems or unwanted effects that may be caused by argatroban. Be sure to keep all appointments.
argatroban may increase your chance of bleeding. Check with your doctor right away if you notice any unusual bleeding or bruising; black, tarry stools; blood in the urine or stools; or pinpoint red spots on your skin. Avoid picking your nose. If you need to blow your nose, blow it gently.
argatroban Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:More common
- Bleeding from the bladder
- blood in the urine
- blurred vision
- chest pain
- dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
- no blood pressure or pulse
- stopping of heart
- unusual tiredness or weakness
- Arm, back, or jaw pain
- bloody or black, tarry stools
- chest tightness or heaviness
- cough or hoarseness
- coughing or spitting up blood
- fast, slow, or irregular heartbeat
- fast, pounding, or irregular heartbeat or pulse
- lower back or side pain
- pain or discomfort in the arms, jaw, back, or neck
- painful or difficult urination
- severe stomach pain
- shortness of breath
- vomiting of blood or material that looks like coffee grounds
- Abdominal pain or swelling
- back pain or backaches
- blue lips and fingernails
- changes in skin color
- cold hands and feet
- coughing that sometimes produces a pink frothy sputum
- difficult, fast, noisy breathing, sometimes with wheezing
- increased sweating
- loss of appetite
- pain, redness, or swelling in the arm or leg
- pains in the chest, groin, or legs, especially calves of the legs
- pale skin
- passing of gas
- severe headaches of sudden onset
- stomach pain, fullness, or discomfort
- sudden loss of coordination
- sudden onset of shortness of breath for no apparent reason
- sudden onset of slurred speech
- sudden vision changes
- swelling in the legs and ankles
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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More about argatroban
- Other brands: Acova