The Ubiquitin System: Function, Physiology and its Role in Disease, 2018
- Start Date:
- Sunday, 3 June, 2018
- End Date:
- Wednesday, 6 June, 2018 12:00pm
- Internal Medicine
We have reached a fascinating point in the field of ubiquitin research. The attachment of ubiquitin to a protein in the cytosol was first identified as a means to enable the degradation of this protein by the proteasome. Much later it became clear that the ubiquitin system fulfils another crucial cellular function: through the dynamics offered by ubiquitination and subsequent deubiquitination it gives signalling platforms in a plethora of signal transduction pathways the means to initiate but, importantly, also to end the triggering of particular signals originating from these platforms.
Whilst some of the signalling-related functions of the ubiquitin system are mediated via its proteasome-targeting function, the majority of these are mediated by different types of ubiquitin chains acting as scaffolds for the recruitment of signalling modules to protein complexes which serve as platforms for the triggering of specific signalling complexes. Rather than discussing mainly structural aspects of the ubiquitin system, this conference is dedicated to the study of functional roles of the ubiquitin system, how it works to ensure normal signal transduction, what are the pathological consequences when it is perturbed and how we may be able to address such perturbances therapeutically in various diseases including cancer, autoimmunity and neurodegeneration.
Price: Academic from : USD 1823.00, Industry from: USD 1823.00, Student from : USD 1534.00 Speakers: Dr. Vishva Dixit (Genentech), Prof. Henning Walczak (Cancer Research UK - UCL Centre)
Melia Nassau Beach All Inclusive,
W Bay St,
Conference organized by Fusion Conferences