Skip to Content

Medications for Pruritus

Other names: Itching; Itchy Skin

What is Pruritus: 1. Itching, an unpleasant cutaneous sensation that provokes the desire to rub or scratch the skin to obtain relief.

2. Any of various conditions marked by itching, the specific site or type being indicated by a modifying term.

Compare drugs associated with Pruritus

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
hydroxyzine Rx N N X 27 reviews
7.0

Generic name: hydroxyzine systemic

Brand name:  Vistaril

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, antihistamines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
diphenhydramine Rx/OTC B N X Add review
9.0

Generic name: diphenhydramine systemic

Brand names:  Benadryl, Benadryl Allergy, Banophen, Diphenhist, Benadryl Children's Allergy, Dicopanol, Diphedryl, Allermax, Ben-Tann, Complete Allergy Relief, Dytan, Dytuss, Scot-Tussin Allergy, Silphen Cough, Twilite, Valu-Dryl

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, antihistamines, anticholinergic antiemetics, anticholinergic antiparkinson agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
hydrocortisone Rx/OTC C N 3 reviews
7.0

Generic name: hydrocortisone topical

Brand names:  Anucort-HC, Cortizone-10, Proctosol-HC, Proctozone HC, Westcort, Ala-Cort, Locoid, Cortaid, Hytone, Ala-Scalp, Ala-Scalp HP, Anumed-HC, Anusol-HC, Anusol-HC Suppositories, Aqua Glycolic HC, Aquanil HC, Beta HC, Bioelements Immediate Comfort, Caldecort, Cetacort, Cortaid Maximum Strength, Corticaine, Cortizone-5, Cortizone-10 Anal Itch Cream, Cotacort, Dermarest Plus Anti-Itch, Dermasorb HC, Dermtex HC, Gly-Cort, Gynecort Maximum Strength, Hydrocortisone with Aloe, Instacort, Itch-X Lotion, Keratol HC, Lacticare-HC, Locoid Lipocream, NuCort, Nutracort, Pandel, Pediaderm HC, Preparation H Anti-Itch Cream Hydrocortisone 1%, Procto-Kit 1%, Procto-Kit 2.5%, Procto-Med HC, Procto-Pak 1%, ProctoCare-HC, Proctocort, Proctocream-HC, Proctosert HC, Proctozone-H, Recort Plus, Rectacort-HC, Rectasol-HC, Sarnol-HC, Scalacort, Scalp-Cort, Scalpicin, Texacort, Tucks Hydrocortisone Anti-Itch Ointment, U-Cort

Drug class: topical steroids

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
gabapentin Off Label Rx C N X 2 reviews
9.0

Generic name: gabapentin systemic

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
ondansetron Off Label Rx B N Add review Add

Generic name: ondansetron systemic

Brand names:  Zofran, Zofran ODT

Drug class: 5HT3 receptor antagonists

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
ammonium lactate Rx/OTC B N Add review
9.0

Generic name: ammonium lactate topical

Brand names:  AmLactin, Lac-Hydrin, Geri-Hydrolac, Kerasal AL, Laclotion

Drug class: topical emollients

For consumers: dosage, side effects

For professionals: Prescribing Information

 
cyproheptadine Rx B N X Add review
9.0

Generic name: cyproheptadine systemic

Drug class: antihistamines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
lidocaine Rx/OTC B N Add review Add

Generic name: lidocaine topical

Brand names:  Xylocaine Jelly, Xylocaine Topical, AneCream, Anestafoam, Bactine, Senatec, CidalEaze, DermacinRx Lidotral´╗┐, DermacinRx Lido V Pak, Eha Lotion, LidaMantle, Lidocream, Lidopin, LidoRx, LidoRxKit, Lidotrans 5 Pak, Lidovex, Lidozol, Medi-Quik Spray, Regenecare HA Spray

Drug class: topical anesthetics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
doxepin Rx B N X 1 review
9.0

Generic name: doxepin topical

Brand names:  Zonalon, Prudoxin

Drug class: topical antihistamines

For consumers: interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
calamine OTC N N 2 reviews
9.0

Generic name: calamine topical

Brand name:  Calamine Plain

Drug class: miscellaneous topical agents

For consumers: side effects

 
diphenhydramine OTC B N Add review Add

Generic name: diphenhydramine topical

Brand names:  Derma-Pax, Dermarest

Drug class: topical antihistamines

For consumers: interactions, side effects

For professionals: A-Z Drug Facts

 
benzocaine Rx/OTC C N 3 reviews
8.0

Generic name: benzocaine topical

Brand names:  Anacaine, Chiggerex, Dermoplast, Lanacane, Skeeter Stik, Sting-Kill, Sting Relief

Drug class: topical anesthetics

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
calamine / diphenhydramine OTC N N 1 review
10

Generic name: calamine / diphenhydramine topical

Brand name:  Ivarest

Drug class: topical antihistamines

For consumers: interactions,

 
crotamiton Rx C N 3 reviews
9.0

Generic name: crotamiton topical

Brand name:  Eurax

Drug class: topical anti-infectives

For consumers: dosage, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
pramoxine Rx/OTC N N 4 reviews
9.0

Generic name: pramoxine topical

Brand names:  Sarna Sensitive, Calaclear, Curasore, Gold Bond Anti-Itch, Itch-X, Pramox, Prax, Prax Wipe, Sarna Ultra, Summers Eve Anti-Itch

Drug class: topical anesthetics

For consumers: dosage, side effects

For professionals: AHFS DI Monograph

 
clioquinol / hydrocortisone Rx C N Add review Add

Generic name: clioquinol / hydrocortisone topical

Brand name:  Ala-Quin

Drug class: topical steroids with anti-infectives

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts

 
diphenhydramine / hydrocortisone OTC N N 1 review
10

Generic name: diphenhydramine / hydrocortisone topical

Brand name:  HC-Derma-Pax

Drug class: miscellaneous topical agents

For consumers: interactions, side effects

 
menthol Rx/OTC N N Add review Add

Generic name: menthol topical

Drug class: topical rubefacient

For consumers: dosage, side effects

For professionals: Prescribing Information

 
dimethicone Off Label OTC U Add review Add

Generic name: dimethicone topical

For consumers: side effects

Off Label: Yes

 
hydrocortisone / lidocaine Rx C N Add review Add

Generic name: hydrocortisone / lidocaine topical

Brand names:  Ana-Lex, AnaMantle HC, LidaMantle HC, LidaMantle HC Relief, Lidocort, Peranex HC, Rectacreme HC, RectaGel HC

Drug class: topical anesthetics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 

Topics under Pruritus

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Browse Drugs by Condition

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Hide