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Medications for Migraine

Drugs associated with Migraine

The following drugs and medications are in some way related to, or used in the treatment of this condition.

What is Migraine: Migraine headaches are a type of headache that some people get repeatedly over time. Migraines are different from other headaches because they occur with symptoms such as nausea, vomiting, or sensitivity to light.

Some people who get migraines have warning symptoms, called an aura, before the actual headache begins. Most people, however, do not have such warning symptoms.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
Anacin Advanced Headache Formula OTC N N X Add review Add

Generic name: acetaminophen / aspirin / caffeine systemic

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

 
Antiflex Off Label Rx C N X Add review Add

Generic name: orphenadrine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

Off Label: Yes

 
Backaid Inflammatory Pain Formula OTC N N X Add review Add

Generic name: acetaminophen / aspirin / caffeine systemic

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

 
Genace OTC N N X Add review Add

Generic name: acetaminophen / aspirin / caffeine systemic

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

 
Goody's Headache Powders OTC N N X Add review Add

Generic name: acetaminophen / aspirin / caffeine systemic

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

 
Levacet Rx/OTC N N X Add review Add

Generic name: acetaminophen / aspirin / caffeine / salicylamide systemic

Drug class: analgesic combinations

For consumers: interactions, side effects

 
Migraine Formula OTC N N X Add review Add

Generic name: acetaminophen / aspirin / caffeine systemic

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Migraine Relief OTC N N X Add review Add

Generic name: acetaminophen / aspirin / caffeine systemic

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Mio-Rel Off Label Rx C N X Add review Add

Generic name: orphenadrine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

Off Label: Yes

 
Onzetra Xsail Rx C N Add review Add

Generic name: sumatriptan systemic

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Orfro Off Label Rx C N X Add review Add

Generic name: orphenadrine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

Off Label: Yes

 
Orphenate Off Label Rx C N X Add review Add

Generic name: orphenadrine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

Off Label: Yes

 
Vanquish OTC N N X Add review Add

Generic name: acetaminophen / aspirin / caffeine systemic

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

 
Zembrace SymTouch Rx C N Add review Add

Generic name: sumatriptan systemic

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
metoclopramide Rx B N X 58 reviews
4.0

Generic name: metoclopramide systemic

Brand name:  Reglan

Drug class: GI stimulants, miscellaneous antiemetics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Norflex Off Label Rx C N X 1 review
4.0

Generic name: orphenadrine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Reglan Rx B N X 37 reviews
4.0

Generic name: metoclopramide systemic

Drug class: GI stimulants, miscellaneous antiemetics

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Zecuity Rx C N 4 reviews
5.0

Generic name: sumatriptan systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
ergotamine Rx X N 3 reviews
6.0

Generic name: ergotamine systemic

Brand name:  Ergomar

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
orphenadrine Off Label Rx C N X 4 reviews
6.0

Generic name: orphenadrine systemic

Brand names:  Norflex, Antiflex, Mio-Rel, Orfro, Orphenate

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
acetaminophen / aspirin / caffeine OTC N N X 89 reviews
7.0

Generic name: acetaminophen / aspirin / caffeine systemic

Brand names:  Excedrin Migraine, Excedrin, Anacin Advanced Headache Formula, Backaid Inflammatory Pain Formula, Genace, Goody's Extra-Strength Headache Powders, Goody's Headache Powders, Migraine Formula, Migraine Relief, Vanquish

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

 
Botox Rx C N 7 reviews
7.0

Generic name: onabotulinumtoxinA systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
cyclobenzaprine Off Label Rx B N X 24 reviews
7.0

Generic name: cyclobenzaprine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
cyproheptadine Rx B N X 22 reviews
7.0

Generic name: cyproheptadine systemic

Drug class: antihistamines

For consumers: interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
D.H.E. 45 Rx X N 4 reviews
7.0

Generic name: dihydroergotamine systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
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Topics under Migraine

Alternative treatments for Migraine

The following products are considered to be alternative treatments or natural remedies for Migraine. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Migraine.

Learn more about Migraine

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N The drug is not subject to the Controlled Substances Act.
1 The drug has a high potential for abuse. The drug has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use of the drug under medical supervision.
2 The drug has a high potential for abuse. The drug has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse of the drug may lead to severe psychological or physical dependence.
3 The drug has a potential for abuse less than the drugs in schedules 1 and 2. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to moderate or low physical dependence or high psychological dependence.
4 The drug has a low potential for abuse relative to the drugs in schedule 3. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to limited physical dependence or psychological dependence relative to the drugs in schedule 3.
5 The drug has a low potential for abuse relative to the drugs in schedule 4. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to limited physical dependence or psychological dependence relative to the drugs in schedule 4.
Alcohol
X Interacts with Alcohol.

Synonym(s): Basilar Artery Migraine; Basilar-Type Migraine; Complicated Migraine; Hemiplegic Migraine; Migraine Headache

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