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Medications for Migraine Prevention (Migraine Prophylaxis)

Drugs associated with Migraine Prevention

The following drugs and medications are in some way related to, or used in the treatment of this condition.

What is Migraine Prevention: Measures taken to prevent migraine headaches, a type of headache that some people get repeatedly over time.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
topiramate Rx D N X 370 reviews
6.0

Generic name: topiramate systemic

Brand names:  Topamax, Topamax Sprinkle, Topiragen

Drug class: carbonic anhydrase inhibitor anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
propranolol Rx C N X 120 reviews
7.0

Generic name: propranolol systemic

Brand names:  Inderal, Inderal LA, InnoPran XL

Drug class: non-cardioselective beta blockers, group II antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
amitriptyline Off Label Rx C N X 205 reviews
7.0

Generic name: amitriptyline systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
verapamil Rx C N X 38 reviews
7.0

Generic name: verapamil systemic

Brand names:  Calan SR, Calan, Verelan, Isoptin SR, Covera-HS, Verelan PM

Drug class: calcium channel blocking agents, group IV antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
nortriptyline Off Label Rx N N X 118 reviews
8.0

Generic name: nortriptyline systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
amlodipine Off Label Rx C N 24 reviews
9.0

Generic name: amlodipine systemic

Brand name:  Norvasc

Drug class: calcium channel blocking agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
atenolol Rx D N X 18 reviews
7.0

Generic name: atenolol systemic

Brand name:  Tenormin

Drug class: cardioselective beta blockers

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
lisinopril Off Label Rx D N 16 reviews
8.0

Generic name: lisinopril systemic

Drug class: angiotensin converting enzyme inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
baclofen Off Label Rx C N X 11 reviews
8.0

Generic name: baclofen systemic

Brand names:  Lioresal, Kemstro

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
clonazepam Off Label Rx D 4 X 17 reviews
7.0

Generic name: clonazepam systemic

Drug class: benzodiazepines, benzodiazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
clonidine Off Label Rx C N X 3 reviews
7.0

Generic name: clonidine systemic

Brand names:  Catapres, Catapres-TTS

Drug class: antiadrenergic agents, centrally acting

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
divalproex sodium Rx D N X 53 reviews
6.0

Generic name: divalproex sodium systemic

Brand names:  Depakote, Depakote ER, Depakote Sprinkles

Drug class: fatty acid derivative anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
metoprolol Off Label Rx C N X 8 reviews
9.0

Generic name: metoprolol systemic

Drug class: cardioselective beta blockers

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
zonisamide Off Label Rx C N X 21 reviews
6.0

Generic name: zonisamide systemic

Brand name:  Zonegran

Drug class: carbonic anhydrase inhibitor anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
nadolol Rx C N X 14 reviews
7.0

Generic name: nadolol systemic

Brand name:  Corgard

Drug class: non-cardioselective beta blockers

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
bupropion Off Label Rx C N X 2 reviews
6.0

Generic name: bupropion systemic

Drug class: miscellaneous antidepressants, smoking cessation agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
lamotrigine Off Label Rx C N X 6 reviews
7.0

Generic name: lamotrigine systemic

Drug class: triazine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
olmesartan Off Label Rx D N 2 reviews
9.0

Generic name: olmesartan systemic

Brand name:  Benicar

Drug class: angiotensin receptor blockers

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

Off Label: Yes

 
nifedipine Rx C N Add review Add

Generic name: nifedipine systemic

Drug class: calcium channel blocking agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
onabotulinumtoxinA Rx C N 59 reviews
7.0

Generic name: onabotulinumtoxinA systemic

Brand name:  Botox

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
riboflavin Off Label Rx/OTC C N 3 reviews
6.0

Generic name: riboflavin systemic

Brand name:  Vitamin B2

Drug class: vitamins

For consumers: side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

Off Label: Yes

 
valproic acid Rx D N X 2 reviews
8.0

Generic name: valproic acid systemic

Brand name:  Stavzor

Drug class: fatty acid derivative anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
pregabalin Off Label Rx C 5 X 8 reviews
7.0

Generic name: pregabalin systemic

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

Off Label: Yes

 
timolol Rx C N X Add review Add

Generic name: timolol systemic

Brand name:  Blocadren

Drug class: non-cardioselective beta blockers

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
acebutolol Off Label Rx B N X Add review Add

Generic name: acebutolol systemic

Drug class: cardioselective beta blockers, group II antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
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Alternative treatments for Migraine Prevention

The following products are considered to be alternative treatments or natural remedies for Migraine Prevention. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Migraine Prevention.

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N The drug is not subject to the Controlled Substances Act.
1 The drug has a high potential for abuse. The drug has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use of the drug under medical supervision.
2 The drug has a high potential for abuse. The drug has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse of the drug may lead to severe psychological or physical dependence.
3 The drug has a potential for abuse less than the drugs in schedules 1 and 2. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to moderate or low physical dependence or high psychological dependence.
4 The drug has a low potential for abuse relative to the drugs in schedule 3. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to limited physical dependence or psychological dependence relative to the drugs in schedule 3.
5 The drug has a low potential for abuse relative to the drugs in schedule 4. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to limited physical dependence or psychological dependence relative to the drugs in schedule 4.
Alcohol
X Interacts with Alcohol.

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