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Medications for Insomnia

Drugs associated with Insomnia

The following drugs and medications are in some way related to, or used in the treatment of this condition.

What is Insomnia: Inability to sleep, abnormal wakefulness.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
trazodone Off Label Rx C N X 403 reviews
7.0

Generic name: trazodone systemic

Drug class: phenylpiperazine antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
zolpidem Rx C 4 X 577 reviews
7.0

Generic name: zolpidem systemic

Brand names:  Ambien, Ambien CR, Intermezzo, Edluar, Zolpimist

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
temazepam Rx X 4 X 198 reviews
6.0

Generic name: temazepam systemic

Brand name:  Restoril

Drug class: benzodiazepines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
amitriptyline Rx C N X 119 reviews
7.0

Generic name: amitriptyline systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
lorazepam Rx D 4 X 46 reviews
8.0

Generic name: lorazepam systemic

Brand name:  Ativan

Drug class: benzodiazepines, miscellaneous antiemetics, benzodiazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
clonazepam Off Label Rx D 4 X 70 reviews
8.0

Generic name: clonazepam systemic

Drug class: benzodiazepines, benzodiazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
diphenhydramine Rx/OTC B N X 70 reviews
6.0

Generic name: diphenhydramine systemic

Brand names:  Compoz Nighttime Sleep Aid, Nytol, Simply Sleep, Sominex, Unisom SleepGels, Unisom SleepMelts, Nytol QuickCaps, Sleepinal, Tranquil Nighttime Sleep Aid, Twilite, Z-Sleep, ZzzQuil

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, antihistamines, anticholinergic antiemetics, anticholinergic antiparkinson agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
doxepin Rx N N X 141 reviews
6.0

Generic name: doxepin systemic

Brand name:  Silenor

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
gabapentin Off Label Rx C N X 45 reviews
8.0

Generic name: gabapentin systemic

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
eszopiclone Rx C 4 X 170 reviews
6.0

Generic name: eszopiclone systemic

Brand name:  Lunesta

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
mirtazapine Off Label Rx C N X 107 reviews
8.0

Generic name: mirtazapine systemic

Drug class: tetracyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
doxylamine Rx/OTC B N X 74 reviews
7.0

Generic name: doxylamine systemic

Brand names:  Unisom SleepTabs, Aldex AN, Aldex AN Chewable, Care One Sleep Aid, Doxytex, Equaline Sleep Aid, Equate Sleep Aid, Medi-Sleep, Nighttime Sleepaid, Sleep Aid

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
flurazepam Rx N 4 X 19 reviews
8.0

Generic name: flurazepam systemic

Brand name:  Dalmane

Drug class: benzodiazepines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
quetiapine Off Label Rx C N X 187 reviews
8.0

Generic name: quetiapine systemic

Drug class: atypical antipsychotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
triazolam Rx X 4 X 25 reviews
8.0

Generic name: triazolam systemic

Brand name:  Halcion

Drug class: benzodiazepines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
diphenhydramine / ibuprofen OTC N N X 1 review
6.0

Generic name: diphenhydramine / ibuprofen systemic

Brand names:  Advil PM, Ibuprofen PM, Motrin PM

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
estazolam Rx X 4 X 13 reviews
8.0

Generic name: estazolam systemic

Brand name:  Prosom

Drug class: benzodiazepines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
olanzapine Off Label Rx C N X 19 reviews
7.0

Generic name: olanzapine systemic

Brand names:  Zyprexa Zydis, Zyprexa

Drug class: atypical antipsychotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
zaleplon Rx C 4 X 55 reviews
6.0

Generic name: zaleplon systemic

Brand name:  Sonata

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
secobarbital Rx D 2 X 5 reviews
10

Generic name: secobarbital systemic

Brand names:  Seconal, Seconal Sodium

Drug class: barbiturates

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts

 
acetaminophen / diphenhydramine Rx/OTC N N X 15 reviews
7.0

Generic name: acetaminophen / diphenhydramine systemic

Brand names:  Tylenol PM, Aceta-Gesic, Excedrin PM, Headache Relief PM, Legatrin PM, Mapap PM, Midol PM, Night Time Pain, Pain Relief PM Extra Strength, Percogesic Extra Strength, Tylenol Sore Throat Nighttime, Unisom PM Pain

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

 
chloral hydrate Rx C 4 X 16 reviews
7.0

Generic name: chloral hydrate systemic

Brand name:  Aquachloral Supprettes

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
oxazepam Off Label Rx N 4 X 4 reviews
7.0

Generic name: oxazepam systemic

Drug class: benzodiazepines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
quazepam Rx C 4 X 4 reviews
10

Generic name: quazepam systemic

Brand name:  Doral

Drug class: benzodiazepines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
ramelteon Rx C N X 49 reviews
4.0

Generic name: ramelteon systemic

Brand name:  Rozerem

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
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Topics under Insomnia

Alternative treatments for Insomnia

The following products are considered to be alternative treatments or natural remedies for Insomnia. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Insomnia.

Learn more about Insomnia

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N The drug is not subject to the Controlled Substances Act.
1 The drug has a high potential for abuse. The drug has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use of the drug under medical supervision.
2 The drug has a high potential for abuse. The drug has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse of the drug may lead to severe psychological or physical dependence.
3 The drug has a potential for abuse less than the drugs in schedules 1 and 2. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to moderate or low physical dependence or high psychological dependence.
4 The drug has a low potential for abuse relative to the drugs in schedule 3. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to limited physical dependence or psychological dependence relative to the drugs in schedule 3.
5 The drug has a low potential for abuse relative to the drugs in schedule 4. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to limited physical dependence or psychological dependence relative to the drugs in schedule 4.
Alcohol
X Interacts with Alcohol.

Synonym(s): Difficulty sleeping; Dyssomnia; Inability to sleep; Sleeplessness; Wakefulness

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