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Medications for Diabetic Peripheral Neuropathy

Other names: Diabetic Nerve Damage; DPN

What is Diabetic Peripheral Neuropathy: A common complication of diabetes mellitus in which nerves are damaged as a result of hyperglycemia (high blood sugar levels).

Compare drugs associated with Diabetic Peripheral Neuropathy

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
gabapentin Off Label Rx C N X 33 reviews
6.0

Generic name: gabapentin systemic

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
pregabalin Rx C 5 X 49 reviews
6.0

Generic name: pregabalin systemic

Brand name:  Lyrica

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
duloxetine Rx C N X 31 reviews
6.0

Generic name: duloxetine systemic

Brand names:  Cymbalta, Irenka

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
tapentadol Rx C 2 X 7 reviews
8.0

Generic name: tapentadol systemic

Brand name:  Nucynta ER

Drug class: narcotic analgesics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
topiramate Off Label Rx D N X 6 reviews
8.0

Generic name: topiramate systemic

Brand names:  Topamax, Topamax Sprinkle, Topiragen

Drug class: carbonic anhydrase inhibitor anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
nortriptyline Off Label Rx N N X 3 reviews
4.0

Generic name: nortriptyline systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
capsaicin Rx/OTC B N 5 reviews
4.0

Generic name: capsaicin topical

Brand names:  Zostrix Diabetic Foot Pain, Capsicum Oleoresin, Capzasin, Axsain, Capsin, Salonpas Pain Patch with Capsaicin, Zostrix, Zostrix Neuropathy, Capzasin-HP, Capzasin-P, Icy Hot PM Patch, Menthac Arthritis Cream with Capsaicin, Salonpas Gel-Patch, Sloan's Liniment, Trixaicin, Trixaicin HP, Zostrix-HP, Zostrix Foot Pain, Capzasin Back and Body, Castiva Warming, GNP Capsaicin, Zostrix Sports

Drug class: miscellaneous topical agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts

 
carbamazepine Off Label Rx D N X Add review
7.0

Generic name: carbamazepine systemic

Drug class: dibenzazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
mexiletine Off Label Rx C N 1 review
8.0

Generic name: mexiletine systemic

Drug class: group I antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 

Alternative treatments for Diabetic Peripheral Neuropathy

The following products are considered to be alternative treatments or natural remedies for Diabetic Peripheral Neuropathy. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Diabetic Peripheral Neuropathy.

  • Evening primrose

Learn more about Diabetic Peripheral Neuropathy

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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