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Medications for Cold Symptoms

Other names: Cold; Common Cold; Coryza

What is Cold Symptoms:  Symptoms of a viral infection involving the upper respiratory tract and characterized by congestion of the nasal mucous membrane, watery nasal rhinorrhea, and general malaise, with a duration of 3–5 days.

Medications to treat Cold Symptoms

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
diphenhydramine B N X 4 reviews
7.0

Generic name: diphenhydramine systemic

Brand names:  Benadryl, Benadryl Allergy, Banophen, Benadryl Children's Allergy, Diphedryl, Q-Dryl, Complete Allergy Relief, Allermax, Dicopanol, Diphenhist, Dytuss, Quenalin, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Twilite, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, antihistamines, anticholinergic antiemetics, anticholinergic antiparkinson agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
chlorpheniramine B N X 1 review
7.0

Generic name: chlorpheniramine systemic

Brand names:  Chlor-Trimeton, Allergy Relief, Aller-Chlor, C.P.M., Chlo-Amine, Chlor-Mal, ChlorTan, Ed-Chlortan, Ed ChlorPed, Ed Chlor Ped Jr., PediaTan, Topco Allergy, Wal-finate

Drug class: antihistamines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
acetaminophen / chlorpheniramine / phenylephrine N N X 9 reviews
6.0

Generic name: acetaminophen / chlorpheniramine / phenylephrine systemic

Brand names:  Robitussin Peak Cold Nighttime Nasal Relief, Tylenol Sinus Congestion & Pain Nighttime, Allergy Multi-Symptom, Contac Cold + Flu (Night Formula), Dristan Cold Multi Symptom Formula, Norel AD, Tylenol Plus Children's Cold, Comtrex Flu Therapy, Comtrex Severe Cold & Sinus, GNP Cold Relief Plus, Medicidin-D, Onset Forte, PX Allergy Sinus PE, Super Strength Sinadrin, Tylenol Allergy Multi-Symptom

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
pseudoephedrine / triprolidine C N X 8 reviews
8.0

Generic name: pseudoephedrine / triprolidine systemic

Brand names:  Actifed, Aprodine, A-Phedrin, Allerfrim, Allerphed, Altafed, Aphedrid, Biofed-PE, Genac, Hist-PSE, Histafed, Pediatex TD, Trip-PSE, Tripohist D, Vi-Sudo, Zymine-D

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
acetaminophen / dextromethorphan / doxylamine / pseudoephedrine N N X 5 reviews
8.0

Generic name: acetaminophen / dextromethorphan / doxylamine / pseudoephedrine systemic

Brand name:  Vicks Nyquil D Cold and Flu Nighttime Relief

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
dexbrompheniramine / pseudoephedrine C N X 9 reviews
10

Generic name: dexbrompheniramine / pseudoephedrine systemic

Brand names:  Drixoral Cold and Allergy, Dixaphedrine, Conex

Drug class: upper respiratory combinations

For consumers: interactions, side effects

For professionals: Prescribing Information

 
chlorpheniramine / hydrocodone C 2 X 14 reviews
8.0

Generic name: chlorpheniramine / hydrocodone systemic

Brand names:  Tussionex Pennkinetic, TussiCaps, S-T Forte 2

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
acetaminophen / chlorpheniramine / dextromethorphan / pseudoephedrine N N X 1 review
5.0

Generic name: acetaminophen / chlorpheniramine / dextromethorphan / pseudoephedrine systemic

Brand names:  Tylenol Cold, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Childrens Tylenol Cold Plus Cough, Comtrex Cold and Flu Maximum Strength Tablet, Theracaps Multi-Symptom Cough & Cold Reliever

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
acetaminophen / chlorpheniramine N N X 7 reviews
6.0

Generic name: acetaminophen / chlorpheniramine systemic

Brand name:  Coricidin HBP Cold & Flu

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
acetaminophen / dextromethorphan / phenylephrine N N X Add review Rate

Generic name: acetaminophen / dextromethorphan / phenylephrine systemic

Brand names:  Vicks Dayquil Cold & Flu Relief, Tylenol Cold Max Day, Theraflu Daytime Severe Cold & Cough, Comtrex Cold and Cough Maximum Strength, Theraflu Warming Relief Daytime Severe Cold & Cough, Sudafed PE Pressure+Pain+Cough, Comtrex Cold & Cough, Flu & Severe Cold & Cough Daytime Powder, Mapap Cold Formula, Robitussin Peak Cold Daytime Cold + Flu

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
codeine / guaifenesin / pseudoephedrine C M X 1 review
2.0

Generic name: codeine / guaifenesin / pseudoephedrine systemic

Brand names:  Virtussin DAC, Cheratussin DAC, Robitussin-DAC, Biotussin DAC, Ambifed CD, Guaifen DAC, Lortuss EX, Maxifed-G CD, Mytussin DAC, Nucofed Pediatric Expectorant, Tricode GF, Tusnel C, Zodryl DEC

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
dextromethorphan / promethazine C N X 1 review
10

Generic name: dextromethorphan / promethazine systemic

Brand names:  Promethazine DM, Promethazine with Dextromethorphan, Promethazine with DM

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
ephedrine / guaifenesin N N 8 reviews
9.0

Generic name: ephedrine / guaifenesin systemic

Brand names:  Primatene, Bronkaid

Drug class: upper respiratory combinations

For consumers: interactions, side effects

For professionals: A-Z Drug Facts

 
acetaminophen / dextromethorphan / guaifenesin / phenylephrine N N X 1 review
10

Generic name: acetaminophen / dextromethorphan / guaifenesin / phenylephrine systemic

Brand names:  Vicks DayQuil Severe Cold & Flu, Sudafed PE Cold & Cough, Tylenol Cold & Flu Severe, Tylenol Cold Multi-Symptom Severe, Mucinex Fast-Max Severe Congestion & Cold, Sudafed PE Pressure+Pain+Cold, Delsym Cough+ Cold Day Time, Mucinex Fast-Max Severe Cold, Mucinex Children's Cold, Cough & Sore Throat, Decorel Forte Plus

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
acetaminophen / dextromethorphan / guaifenesin / pseudoephedrine N N X 1 review
10

Generic name: acetaminophen / dextromethorphan / guaifenesin / pseudoephedrine systemic

Brand names:  Robitussin Cold Cough and Flu, Flutabs, Tylenol Cold Severe Congestion Daytime, Duraflu

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
acetaminophen / dextromethorphan / pseudoephedrine N N X 1 review
8.0

Generic name: acetaminophen / dextromethorphan / pseudoephedrine systemic

Brand names:  Vicks Dayquil Daytime Cold / Flu (old formulation), Daytime Cold and Flu Relief, Severe Cold Multi-Symptom, Comtrex Non-Drowsy, Daytime Cold

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
brompheniramine C N X 2 reviews
9.0

Generic name: brompheniramine systemic

Brand names:  Bromax, Brovex CT, Dimetane Extentab, J-Tan PD, Lodrane 12 Hour, LoHist-12, Siltane, VaZol

Drug class: antihistamines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
chlorpheniramine / phenylephrine N N X 6 reviews
8.0

Generic name: chlorpheniramine / phenylephrine systemic

Brand names:  Sudafed PE Sinus & Allergy, Actifed Cold and Allergy, R-Tanna, Ed A-Hist, Rynatan, Sildec-PE, Sinus & Allergy PE, Allan Tannate Pediatric, Allerest PE, BP Allergy JR, ChlorTan D, Dallergy Drops, Ed ChlorPed D, NoHist LQ, Novahistine, Ny-Tannic, Phenagil, Rynatan Pediatric, Sonahist, Triaminic Cold & Allergy

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
acetaminophen / chlorpheniramine / pseudoephedrine N N X Add review
10

Generic name: acetaminophen / chlorpheniramine / pseudoephedrine systemic

Brand names:  Sinarest, Cold Medicine Plus, Sinutab Ex-Strength, Comtrex Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Kolephrin

Drug class: upper respiratory combinations

For consumers: interactions, side effects

 
acetaminophen / phenyltoloxamine N N X Add review Rate

Generic name: acetaminophen / phenyltoloxamine systemic

Brand names:  Dologesic, Percogesic, Acuflex, Ali-Flex, Dologesic DF, Lagesic, Myophen, Relagesic, RhinoFlex 650, Zflex, Zgesic

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

 
chlorpheniramine / ibuprofen / pseudoephedrine D N X Add review
7.0

Generic name: chlorpheniramine / ibuprofen / pseudoephedrine systemic

Brand names:  Advil Allergy Sinus, Advil Children's Allergy Sinus

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
dextromethorphan / phenylephrine / pyrilamine C N X 2 reviews
10

Generic name: dextromethorphan / phenylephrine / pyrilamine systemic

Brand names:  Triplex DM, Codal-DM Syrup, Codimal DM, Codituss DM, Pryil DM, Reme Hist DM

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
diphenhydramine / phenylephrine C N X Add review
8.0

Generic name: diphenhydramine / phenylephrine systemic

Brand names:  Robitussin Night Time Cough & Cold, Triaminic Night Time Cold & Cough, Alahist LQ, Children's Triacting Night Time, D-Tann, Delsym Children's Night Time Cough & Cold, Dimetapp Children's Nighttime Cold & Congestion, Dytan-D, PediaCare Children's Allergy & Cold, Pediatex-CT

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine N N X Add review Rate

Generic name: acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine systemic

Brand names:  Tylenol Cold Multi-Symptom Nighttime, Theraflu Nighttime Severe Cold & Cough Caplets, Multi Symptom Cold Relief, Tylenol Cold Head Congestion Nighttime, Cold Multi-Symptom (Nighttime), Comtrex Nighttime Cold & Cough

Drug class: upper respiratory combinations

For consumers: interactions, side effects

 
acetaminophen / diphenhydramine / phenylephrine C N X 4 reviews
7.0

Generic name: acetaminophen / diphenhydramine / phenylephrine systemic

Brand names:  Benadryl Allergy Plus Cold, Benadryl Allergy Plus Sinus Headache, Theraflu Nighttime Severe Cold & Cough, Sudafed PE Severe Cold, Robitussin Multi-Symptom Cold Night Time, Mucinex Fast-Max Night Time Cold & Flu, Theraflu Warming Relief Flu & Sore Throat, Delsym Cough+ Cold Night Time, Theraflu Warming Relief Nighttime Severe Cold & Cough, Night Time Severe Cold and Cough, Theraflu Warming Relief Sinus & Cold, Tylenol Plus Children's Cold & Allergy

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
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Topics under Cold Symptoms

Alternative treatments for Cold Symptoms

The following products are considered to be alternative treatments or natural remedies for Cold Symptoms. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Cold Symptoms.

Learn more about Cold Symptoms

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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