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Medications for Cold Symptoms

Other names: Cold; Common Cold; Coryza

What is Cold Symptoms:  Symptoms of a viral infection involving the upper respiratory tract and characterized by congestion of the nasal mucous membrane, watery nasal rhinorrhea, and general malaise, with a duration of 3–5 days.

Medications to treat Cold Symptoms

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
diphenhydramine Rx/OTC B N X 4 reviews
7.0

Generic name: diphenhydramine systemic

Brand names:  Benadryl, Benadryl Allergy, Banophen, Benadryl Children's Allergy, Diphedryl, Q-Dryl, Complete Allergy Relief, Allermax, Ben-Tann, Dicopanol, Diphenhist, Dytan, Dytuss, Quenalin, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Twilite, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, antihistamines, anticholinergic antiemetics, anticholinergic antiparkinson agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
chlorpheniramine Rx/OTC B N X 1 review
7.0

Generic name: chlorpheniramine systemic

Brand names:  Chlor-Trimeton, Aller-Chlor, Allergy Relief, Wal-finate, C.P.M., Chlo-Amine, Chlor-Mal, ChlorTan, Ed-Chlortan, Ed ChlorPed, Ed Chlor Ped Jr., PediaTan, Ricobid H, Topco Allergy

Drug class: antihistamines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
acetaminophen / chlorpheniramine / phenylephrine Rx/OTC N N X 6 reviews
5.0

Generic name: acetaminophen / chlorpheniramine / phenylephrine systemic

Brand names:  Robitussin Peak Cold Nighttime Nasal Relief, Tylenol Sinus Congestion & Pain Nighttime, Contac Cold + Flu (Night Formula), Dristan Cold Multi Symptom Formula, Tylenol Plus Children's Cold, Comtrex Severe Cold & Sinus, Dryphen, GNP Cold Relief Plus, Protid, Pyrroxate, Tylenol Allergy Multi-Symptom

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
pseudoephedrine / triprolidine Rx/OTC C N X 7 reviews
8.0

Generic name: pseudoephedrine / triprolidine systemic

Brand names:  Actifed, Aprodine, A-Phedrin, Allerfrim, Allerphed, Altafed, Aphedrid, Biofed-PE, Genac, Hist-PSE, Histafed, Pediatex TD, Trip-PSE, Tripohist D, Vi-Sudo, Zymine-D

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
acetaminophen / dextromethorphan / doxylamine / pseudoephedrine OTC N N X 5 reviews
8.0

Generic name: acetaminophen / dextromethorphan / doxylamine / pseudoephedrine systemic

Brand names:  Vicks Nyquil D Cold and Flu Nighttime Relief, Tylenol Severe Cold & Flu Night Time

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
dexbrompheniramine / pseudoephedrine Rx/OTC C N X 8 reviews
10

Generic name: dexbrompheniramine / pseudoephedrine systemic

Brand names:  Drixoral Cold and Allergy, Dixaphedrine, Conex

Drug class: upper respiratory combinations

For consumers: interactions, side effects

For professionals: Prescribing Information

 
chlorpheniramine / hydrocodone Rx C 2 X 14 reviews
8.0

Generic name: chlorpheniramine / hydrocodone systemic

Brand names:  Tussionex Pennkinetic, TussiCaps, S-T Forte 2

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
acetaminophen / chlorpheniramine / dextromethorphan / pseudoephedrine OTC N N X 1 review
5.0

Generic name: acetaminophen / chlorpheniramine / dextromethorphan / pseudoephedrine systemic

Brand names:  Tylenol Cold, Comtrex Cold and Flu Maximum Strength Tablet

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
acetaminophen / chlorpheniramine OTC N N X 6 reviews
7.0

Generic name: acetaminophen / chlorpheniramine systemic

Brand names:  Coricidin HBP Cold & Flu, Congestant

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
acetaminophen / dextromethorphan / phenylephrine OTC N N X Add review Add

Generic name: acetaminophen / dextromethorphan / phenylephrine systemic

Brand names:  Vicks Dayquil Cold & Flu Relief, Tylenol Cold Max Day, Theraflu Daytime Severe Cold & Cough, Theraflu Warming Relief Daytime Severe Cold & Cough, Comtrex Cold and Cough Maximum Strength, Sudafed PE Pressure+Pain+Cough, Comtrex Cold & Cough, Flu & Severe Cold & Cough Daytime Powder, Little Colds Multi-Symptom, Mapap Cold Formula, Robitussin Peak Cold Daytime Cold + Flu

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
codeine / guaifenesin / pseudoephedrine Rx/OTC C M X 1 review
2.0

Generic name: codeine / guaifenesin / pseudoephedrine systemic

Brand names:  Virtussin DAC, Cheratussin DAC, Robitussin-DAC, Biotussin DAC, Maxifed CD, Ambifed-G CD, Ambifed CD, Guaifen DAC, Lortuss EX, Maxifed-G CD, Maxifed-G CDX, Mytussin DAC, Nucofed Expectorant, Nucofed Pediatric Expectorant, Suttar-2, Suttar SF, Tricode GF, Tusnel C, Z-Tuss E, Zodryl DEC

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
acetaminophen / dextromethorphan / guaifenesin / pseudoephedrine Rx/OTC N N X 1 review
10

Generic name: acetaminophen / dextromethorphan / guaifenesin / pseudoephedrine systemic

Brand names:  Robitussin Cold Cough and Flu, Flutabs, Duraflu, Tylenol Cold Severe Congestion Daytime

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
acetaminophen / dextromethorphan / pseudoephedrine OTC N N X 1 review
8.0

Generic name: acetaminophen / dextromethorphan / pseudoephedrine systemic

Brand names:  Vicks Dayquil Daytime Cold / Flu, Comtrex Non-Drowsy, Contac Severe Cold and Flu Non Drowsy, Daytime Cold

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
brompheniramine Rx/OTC C N X 2 reviews
9.0

Generic name: brompheniramine systemic

Brand names:  Bromax, Brovex, Brovex CT, Dimetane Extentab, J-Tan, J-Tan PD, Lodrane 12 Hour, Lodrane 24, LoHist-12, Siltane, VaZol

Drug class: antihistamines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
chlorpheniramine / phenylephrine Rx/OTC N N X 6 reviews
8.0

Generic name: chlorpheniramine / phenylephrine systemic

Brand names:  Sudafed PE Sinus & Allergy, Actifed Cold and Allergy, R-Tanna, AlleRx, Ed A-Hist, Rynatan, Sildec-PE, Sinus & Allergy PE, Allan Tannate Pediatric, Allerest PE, BP Allergy JR, ChlorTan D, Dallergy Drops, Dallergy JR, Ed ChlorPed D, NoHist LQ, Novahistine, Ny-Tannic, Phenagil, Relera, Ricobid NR, Rondec, Rynatan Pediatric, Sonahist, Triaminic Cold & Allergy

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
dextromethorphan / promethazine Rx C N X 1 review
10

Generic name: dextromethorphan / promethazine systemic

Brand names:  Promethazine DM, Promethazine with Dextromethorphan, Promethazine with DM

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
ephedrine / guaifenesin Rx/OTC N N 7 reviews
9.0

Generic name: ephedrine / guaifenesin systemic

Brand names:  Primatene, Broncholate

Drug class: upper respiratory combinations

For consumers: interactions, side effects

For professionals: A-Z Drug Facts

 
acetaminophen / chlorpheniramine / pseudoephedrine OTC N N X Add review
10

Generic name: acetaminophen / chlorpheniramine / pseudoephedrine systemic

Brand names:  Sinutab Ex-Strength, Comtrex Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Nighttime Flu Therapy, Comtrex Sinus and Nasal, Kolephrin

Drug class: upper respiratory combinations

For consumers: interactions, side effects

 
acetaminophen / phenyltoloxamine Rx/OTC N N X Add review Add

Generic name: acetaminophen / phenyltoloxamine systemic

Brand names:  Dologesic, Percogesic, Acuflex, Ali-Flex, Dologesic DF, Lagesic, Myophen, Relagesic, RhinoFlex 650, Zflex, Zgesic

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

 
chlorpheniramine / ibuprofen / pseudoephedrine OTC D N X Add review
7.0

Generic name: chlorpheniramine / ibuprofen / pseudoephedrine systemic

Brand names:  Advil Allergy Sinus, Advil Children's Allergy Sinus

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
dextromethorphan / phenylephrine / pyrilamine Rx/OTC C N X 2 reviews
10

Generic name: dextromethorphan / phenylephrine / pyrilamine systemic

Brand names:  Triplex DM, Codal-DM Syrup, Codimal DM, Codituss DM, Deconsal DM, Pryil DM, Reme Hist DM, Tannate V DM, Viravan-DM

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
diphenhydramine / phenylephrine Rx/OTC C N X Add review
8.0

Generic name: diphenhydramine / phenylephrine systemic

Brand names:  Robitussin Night Time Cough & Cold, Triaminic Night Time Cold & Cough, Alahist LQ, Aldex-CT, Benadryl-D Children's Allergy & Sinus, Children's Triacting Night Time, D-Tann, Dimetapp Children's Nighttime Cold & Congestion, Dytan-D, PediaCare Children's Allergy & Cold, Pediatex-CT

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine OTC N N X Add review Add

Generic name: acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine systemic

Brand name:  Tylenol Plus Children's Flu

Drug class: upper respiratory combinations

For consumers: interactions, side effects

 
acetaminophen / dextromethorphan / guaifenesin / phenylephrine Rx/OTC N N X 1 review
10

Generic name: acetaminophen / dextromethorphan / guaifenesin / phenylephrine systemic

Brand names:  Vicks DayQuil Severe Cold & Flu, Sudafed PE Cold & Cough, Tylenol Cold Multi-Symptom Severe, Tylenol Cold & Flu Severe, Delsym Cough+ Cold Day Time, Mucinex Children's Cold, Cough & Sore Throat, Mucinex Fast-Max Severe Cold

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
acetaminophen / diphenhydramine / phenylephrine Rx/OTC C N X 3 reviews
7.0

Generic name: acetaminophen / diphenhydramine / phenylephrine systemic

Brand names:  Benadryl Allergy Plus Cold, Theraflu Nighttime Severe Cold & Cough, Benadryl Allergy Plus Sinus Headache, Sudafed PE Severe Cold, Robitussin Multi-Symptom Cold Night Time, Mucinex Fast-Max Night Time Cold & Flu, Theraflu Warming Relief Flu & Sore Throat, Delsym Cough+ Cold Night Time, Theraflu Warming Relief Nighttime Severe Cold & Cough, Night Time Severe Cold and Cough, Theraflu Warming Relief Sinus & Cold, Tylenol Plus Children's Cold & Allergy

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

 
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Topics under Cold Symptoms

Alternative treatments for Cold Symptoms

The following products are considered to be alternative treatments or natural remedies for Cold Symptoms. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Cold Symptoms.

Learn more about Cold Symptoms

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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