Xanax Alternatives Compared

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Xanax (alprazolam)	Clonazepam	Alprazolam	Enter another drug to compare

Xanax (alprazolam)

Clonazepam

Alprazolam

Prescription only

Xanax may be used for the treatment of anxiety or panic disorder; however, it is addictive, and withdrawal symptoms can be severe. Can interact with several drugs including those that cause... View more

Prescription only

Clonazepam may reduce seizure frequency in specific seizure disorders and can be used short-term for panic disorder, to relieve anxiety, or to sedate. When used long-term it can cause dependence and... View more

Prescription only

Alprazolam effectively relieves anxiety; however, it is addictive, and withdrawal symptoms can be severe. Other common side effects include low blood pressure, dizziness on standing (which may... View more

More about Xanax (alprazolam)

More about Clonazepam

More about Alprazolam

Ratings & Reviews

Xanax has an average rating of 8.6 out of 10 from a total of 920 ratings on Drugs.com. 82% of reviewers reported a positive effect, while 8% reported a negative effect.

Clonazepam has an average rating of 8.2 out of 10 from a total of 2187 ratings on Drugs.com. 78% of reviewers reported a positive effect, while 12% reported a negative effect.

Alprazolam has an average rating of 8.6 out of 10 from a total of 1494 ratings on Drugs.com. 83% of reviewers reported a positive effect, while 8% reported a negative effect.

View all 920 reviews

View all 2187 reviews

View all 1494 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Addiction (5.7%)
Anxiety (5.5%)
Withdrawal (5.2%)
Drowsiness (4.6%)
Panic attacks (4.5%)
Insomnia (2.8%)
Tiredness (2.4%)

View all Xanax side effects

Anxiety (7.1%)
Drowsiness (6.7%)
Withdrawal (6.5%)
Insomnia (4.7%)
Tiredness (3.2%)
Depression (3.2%)
Panic attacks (3.1%)

View all Clonazepam side effects

Anxiety (6.6%)
Addiction (4.9%)
Withdrawal (4.6%)
Drowsiness (4.4%)
Panic attacks (4.1%)
Insomnia (2.7%)
Tiredness (2.3%)

View all Alprazolam side effects

Drug Class

Benzodiazepines

Benzodiazepines

Generic Availability

Lower cost generic approved

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	100 tablet
Strength	0.25 mg
Per unit^*	$6.09
Cost^*	$609.00

View all Xanax prices

Quantity	100 each
Strength	0.5 mg
Per unit^*	$0.32
Cost^*	$31.88

View all Clonazepam prices

Quantity	100 tablet
Strength	0.5 mg
Per unit^*	$0.33
Cost^*	$33.04

View all Alprazolam prices

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Dosage Forms

Oral tablet

Oral tablet
Oral tablet, disintegrating

Oral concentrate
Oral tablet
Oral tablet, disintegrating
Oral tablet, extended release

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

20 hours

40 hours

20 hours

CSA Schedule ¹ View glossary of CSA terms

Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.

Some potential for abuse

Pregnancy Category

Category D Positive evidence of risk

See the full pregnancy warnings document.

Category D Positive evidence of risk

See the full pregnancy warnings document.

Category D Positive evidence of risk

See the full pregnancy warnings document.

Drug Interactions

A total of 563 drugs are known to interact with Xanax:

55 major drug interactions (214 brand and generic names)
468 moderate drug interactions (1731 brand and generic names)
40 minor drug interactions (331 brand and generic names)

A total of 533 drugs are known to interact with Clonazepam:

30 major drug interactions (155 brand and generic names)
470 moderate drug interactions (1742 brand and generic names)
33 minor drug interactions (210 brand and generic names)

A total of 563 drugs are known to interact with Alprazolam:

55 major drug interactions (214 brand and generic names)
468 moderate drug interactions (1731 brand and generic names)
40 minor drug interactions (331 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Grapefruit and grapefruit juice may interact with ALPRAZolam and lead to potentially dangerous side... View more

Using clonazePAM together with alcohol can increase nervous system side effects such as dizziness... View more

Grapefruit and grapefruit juice may interact with ALPRAZolam and lead to potentially dangerous side... View more

Disease Interactions

First Approval Date

N/A

June 04, 1975

October 16, 1981

WADA Class View classifications

N/A

More Information

Patient Resources

Xanax uses

Clonazepam uses

Alprazolam uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Xanax Alternatives Compared

See also:

Lexapro

Cymbalta

Dupixent

Ativan

Paroxetine

Diazepam

Lorazepam

Venlafaxine

Buspirone

Hydroxyzine

Further information

Xanax Alternatives Compared

See also:

Further information

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