Comparing Glimepiride vs Glucotrol XL

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Glimepiride	Glucotrol XL (glipizide)	Enter another drug to compare

Glimepiride

Glucotrol XL (glipizide)

Prescription only

Glimepiride is used to help maintain blood sugar control in people with type 2 diabetes. It may cause nausea and people who take glimepiride should always be alert for symptoms of hypoglycemia (low... View more

Prescription only

Prescribed for Type 2 Diabetes. Glucotrol XL may also be used for purposes not listed in this medication guide.

More about Glimepiride

More about Glucotrol XL (glipizide)

Ratings & Reviews

Glimepiride has an average rating of 6.7 out of 10 from a total of 71 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 25% reported a negative effect.

Be the first to share your experience with this drug.

View all 71 reviews

Review this drug

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Blood sugar (8.5%)
Weight gain (8.5%)
Stomach pain (7.0%)
Diarrhea (5.6%)
Upset stomach (4.2%)

View all Glimepiride side effects

View all Glucotrol XL side effects

Drug Class

Sulfonylureas

Sulfonylureas

Generic Availability

Lower cost generic

Lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	50 each
Strength	4 mg
Per unit^*	$0.58
Cost^*	$29.24

View all Glimepiride prices

Quantity	100 tablet, extended release
Strength	5 mg
Per unit^*	$0.52
Cost^*	$51.63

View all Glucotrol XL prices

Get free Discount Card

Dosage Forms

Oral tablet

Oral tablet, extended release

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

3.4 hours

4.3 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 503 drugs are known to interact with Glimepiride:

23 major drug interactions (59 brand and generic names)
465 moderate drug interactions (2424 brand and generic names)
15 minor drug interactions (106 brand and generic names)

A total of 485 drugs are known to interact with Glucotrol XL:

23 major drug interactions (59 brand and generic names)
443 moderate drug interactions (2378 brand and generic names)
19 minor drug interactions (116 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more

Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more

Disease Interactions

First Approval Date

November 30, 1995

April 26, 1994

WADA Class View classifications

N/A

More Information

Patient Resources

Glimepiride uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Glimepiride vs Glucotrol XL

See also:

Ozempic

Rybelsus

Mounjaro

Trulicity

Lantus

Tresiba

Victoza

Basaglar

Levemir

Novolog

Further information

Comparing Glimepiride vs Glucotrol XL

See also:

Further information

Compare Drugs