Comparing Epiduo Forte vs Spironolactone
Epiduo Forte Remove Epiduo Forte from your drug comparison | Spironolactone Remove Spironolactone from your drug comparison |
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Epiduo Forte adapalene / benzoyl peroxide Remove Epiduo Forte from your drug comparison | Spironolactone Remove Spironolactone from your drug comparison | ||||||||||||||||
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Prescribed for Acne. Epiduo Forte may also be used for purposes not listed in this medication guide. |
Spironolactone is a diuretic that may be used to remove excess fluid (edema) from the body, lower blood pressure, or treat hyperaldosteronism. It does not cause potassium loss from the body; however,... View more |
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Prescription only |
Prescription only |
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Ratings & ReviewsRecent helpful reviews |
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7.2
For Acne: My daughter's dermatologist prescribed this after she went off of accutane and started getting breakouts again. Accutane cleared her skin up amazingly, but we didn't want to put her back on it if it wasn't necessary. Epiduo Forte really does work. She has been using it for 10 months and her skin looks as clear as it did after 6+ months of accutane. She does still get breakouts, but nothing like before. And she has tried many prescription topical treatments and pills over the years, and none of those worked. She has also managed to make one bottle last 10 months, so she's probably not using enough, but she does say it is very drying. It's very expensive, so be sure and ask your doctor if they know of any rebate programs for it. We get it for $75 after insurance discount and rebate. |
7.3
For Acne: I was on spiro for several years. It helped but didn't completely clear my skin. I still had cystic nodules that were painful and scarred. A new dermatologist upped my dose to 200mg/day. I'm 5'5" and 115lbs. The side effects were bad before, I always had to pee in the middle of the night, but they were significantly worse with the higher dose. I couldn't remember anything. The brain fog was unbelievable. I wasn't on any other medications, so I knew it was the spiro. I decided to stop taking the medication in order to return to graduate school (needed a sharp brain for that). My acne is 100% back but at least I can sleep through the night and remember what I've read. For Acne: I was put on it for “hormonal acne” which is what my derm referred to it as. I only had big bumps around my mouth/chin, around my hair line, and my temples. It was nothing severe but definitely noticeable. She put me on 50 mg spironolactone a day and after 3 months there was only slight difference. She then decided to put me a dose of 100 mg a day and it worked like a charm. My skin purged SO bad for about 6 weeks and then it started clearing up. It made me extremely thirsty and made me lose my appetite because it sort of made me nauseous. But over all, it works great in my opinion |
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Drug Class |
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Side Effects |
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Common side effects include: burning sensation of skin, desquamation, stinging of the skin, erythema of skin, and xeroderma. See the full Epiduo Forte side effects document. |
See the full spironolactone side effects document. |
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Pricing and Coupons* Prices are without insurance |
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View all Epiduo Forte prices and generic prices |
View all spironolactone prices |
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Generic Availability |
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Yes (this medicine) |
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Dosage Form(s) Available |
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Brand Names |
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Other adapalene / benzoyl peroxide brands include: Epiduo | Aldactone, CaroSpir | ||||||||||||||||
Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. |
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51 hours |
37 hours |
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CSA Schedule**View glossary of terms. |
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category |
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Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
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FDA Alerts |
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N/A |
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Drug Interactions |
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A total of 14 drugs are known to interact with Epiduo Forte:
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A total of 347 drugs are known to interact with spironolactone:
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Alcohol/Food/Lifestyle Interactions |
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions |
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First Approval Date |
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July 15, 2015 |
January 21, 1960 |
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WADA ClassView World Anti-Doping Agency classifications. |
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N/A |
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More Information |
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Consumer Resources |
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Professional Resources |
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N/A |
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Related Treatment Guide |
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
For Acne: Epiduo Forte is probably one of the most effective topicals I've used to date (suffered from hormonal cystic acne for 8 years now) and definitely more effective than Epiduo. I've never written a review for an acne medication before so trust me when I say I rely on Epiduo Forte as an effective spot treatment. I find this topical to really help in thwarting those angry cystic pimples and stop em in their tracks. If I get them early and apply the Forte they usually go away or just turn into a regular/smaller pimple with a head. The only thing I hate about it is that it makes the area where you apply the epiduo forte EXTREMELY dried out and flaky, which sucks for a foundation-wearer like myself. The flaking doesn't fully subside til about a week so if you want your makeup to look smooth try not to apply the night before or just apply a very thin layer.