Comparing Depo-Medrol vs Prolia
| Depo-Medrol (methylprednisolone) | Prolia (denosumab) |
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| Depo-Medrol (methylprednisolone) | Prolia (denosumab) |
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Prescription only
Prescribed for Asthma, Allergic Rhinitis, Allergies, Asthma - acute, Asthma - Maintenance, Congenital Adrenal Hyperplasia, Dermatologic Lesion, Gout - Acute, Immunosuppression, Inflammatory... View more |
Prescription only
Prolia is an injection that can be self-administered once every six months for the treatment of osteoporosis. It has been associated with an increased risk of fractures on discontinuation and... View more |
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| More about Depo-Medrol (methylprednisolone) | More about Prolia (denosumab) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Depo-Medrol has an average rating of 5.6 out of 10 from a total of 19 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 47% reported a negative effect. |
Prolia has an average rating of 2.9 out of 10 from a total of 374 ratings on Drugs.com. 16% of reviewers reported a positive effect, while 76% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
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View all Depo-Medrol side effects |
View all Prolia side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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N/A |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Depo-Medrol prices |
View all Prolia prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other methylprednisolone brands include: Medrol, Medrol Dosepak, MethylPREDNISolone Dose Pack, Solu-Medrol | Other denosumab brands include: Bomyntra, Conexxence, Jubbonti, Osenvelt, Ospomyv, Stoboclo, Wyost, Xbryk, Xgeva View more | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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3.5 hours |
609.6 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
Excluding First Trimester
Category D
Positive evidence of risk
First Trimester See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 625 drugs are known to interact with Depo-Medrol:
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A total of 306 drugs are known to interact with Prolia:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
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| First Approval Date | |||||||||||||||||
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May 27, 1959 |
June 01, 2010 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.