Comparing Amantadine vs Methylphenidate

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Amantadine Remove Amantadine from your drug comparison	Methylphenidate Remove Methylphenidate from your drug comparison	Add another drug to compare

Amantadine

Methylphenidate

Amantadine may be used to treat dyskinesia or reduce the number of OFF episodes in those with Parkinson's disease (PD) OR in the treatment or prevention of Influenza A viral infection. Nausea... View more

Methylphenidate improves symptoms of ADHD but carries with it a risk of dependence and side effects such as insomnia are common. To avoid insomnia the last dose should be administered before 6pm... View more

Prescription only

Commonly reported side effects include: insomnia, nausea, headache, vomiting, decreased appetite, and xerostomia.

See the full methylphenidate side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	50 each
Dosage	100 mg
Per Unit^*	$0.75
Cost^*	$37.63

View all amantadine prices

Quantity	30 each
Dosage	10 mg
Per Unit^*	$0.94
Cost^*	$28.14

View all methylphenidate prices

Get free Discount Card

Generic Availability

Yes (this medicine)

Dosage Form(s) Available

Oral capsule
Oral syrup
Oral tablet

Oral capsule, extended release
Oral solution
Oral tablet
Oral tablet, chewable
Oral tablet, extended release

Brand Names

Gocovri, Osmolex ER Adhansia XR, Aptensio XR, Concerta, Cotempla XR-ODT, Daytrana, Jornay PM, Metadate CD, Methylin, Methylin ER, QuilliChew ER, Quillivant XR, Relexxii, Ritalin, Ritalin LA View more

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

19 hours

4 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

High potential for abuse

Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.

Pregnancy Category

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 125 drugs are known to interact with amantadine:

7 major drug interactions (58 brand and generic names)
104 moderate drug interactions (588 brand and generic names)
14 minor drug interactions (49 brand and generic names)

A total of 184 drugs are known to interact with methylphenidate:

19 major drug interactions (90 brand and generic names)
154 moderate drug interactions (572 brand and generic names)
11 minor drug interactions (32 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Do not use alcohol or medications that contain alcohol while you are receiving treatment with... View more

Disease Interactions

First Approval Date

February 14, 1968

December 05, 1955

WADA Class

View World Anti-Doping Agency classifications.

N/A

S6 - Stimulants

More Information

Patient resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer