Parnate for Depression User Reviews (Page 4)

• rea...
• Taken for less than 1 month
• October 20, 2022

"I feel compelled to write this review given the false sense of hope that I experienced as a result of the overwhelming amount of positive reviews on this site. I battled my doctor to get on this medication only to have it cause significant insomnia and a worsening of depression. I made it through 11 nights of 2 hours of sleep before I called it quits. I too was looking for the solution to my depression once the traditionally prescribed medications failed. I wish you the best of luck in your journey, but don't think that the large number of positive reviews on this site is representative of this drug's outcomes. If so, it would be a first-line treatment. With that being said, I hope this medication works for you."

• meg...
• March 26, 2014

"I have been on Parnate for about 3 weeks. Am finding the insomnia really hard, as in the day I can be really tired, like fatigue at times, and am unsure whether this is coming from switching medicines, Zoloft to Parnate, or from just the Parnate, and not being able to sleep properly."

• Jus...
• Taken for 1 to 6 months
• February 7, 2016

"I have found that people around me say that I have improved and seem better. Yet, inside, I still feel like I'm in a deep, dark hole. I've only been on 40 mg for 3 months, however. As for increased sex drive?! When does that happen? It's killed my sex life. Have lost a lot of weight due to food restrictions, but needed to shed a few kilos. I also find it messes with my bladder. Anyone else have this issue? Some days I can pee, no problems, others, it's just painful, and I struggle to pass urine even when busting to go! Though after reading others' stories, it gives me hope that this drug will bring me out of the darkness... as I'm really over being in here. (I had a nervous breakdown.)"

• HAP...
• Taken for 10 years or more
• February 24, 2025

"Parnate has given me a “life” for a long time! I have found over the years that the coating on the tablets can cause absorption problems. Splitting them open resolved the problem. Sometimes, 1/2 tablet more or less solves side effects and/or efficacy. For me, that is 25 mg-35 mg/day. Unfortunately, generic versions are not all equal, if possible, use Parnate Brand. I recently had to return to the Parnate Brand when the generic version did not work, and I ended up in physical withdrawal. (At twice my normal dose did not resolve withdrawal.) The dietary restrictions do matter for me-a reaction can be unpleasant or severe pain. It is just easier to stick with foods you know are safe choices. Again, I have a life, and Parnate made that possible."

• Die...
• Taken for 2 to 5 years
• July 25, 2016

"The best drug for severe depression, except you cannot eat cheese or drink red wine. But try TMS, which is not a drug and has no side effects, or if necessary, ECT, which is the gold standard and is much different than in 'One Flew Over the Cuckoo's Nest.'"

• ste...
• Taken for 1 to 2 years
• January 10, 2025

"I am cured thanks to this miracle drug! No more anxiety and depression! I had to ask the doctor for this because no one ever offered it to me as a treatment! I didn't even know it existed! I love Parnate."

• Del...
• Taken for 1 to 6 months
• September 17, 2016

"I have been taking 20 mg of Parnate every day for a little over a month now after finally convincing my psychiatrist to prescribe it. I really can't say how effective it has been in terms of alleviating the symptoms of my depression. Diet restrictions have not really bothered me at all. No real physical side effects apart from extreme sun sensitivity. This REALLY bothers me because I'm extremely fair-skinned and burn so easily - frequent, and I mean FREQUENT reapplications of sunscreen and sun avoidance are a must for me. Parnate has also decreased the effectiveness of benzodiazepines such as Valium and Imovane. This has been really frustrating because I also suffer from anxiety and insomnia."

• ale...
• Taken for 1 to 6 months
• November 6, 2017

"After failing to get any improvement with a whole range of antidepressants (including TCAs and Wellbutrin), I was very much looking forward to starting on Parnate. Alas, unlike other pills that had literally zero effect, this one added some negative side effects: heartaches, high blood pressure, tense feeling in the chest, and even a visit to a hospital after I fainted (luckily nothing life-threatening). I envy people whose condition improved, though. Also not sure what to do next, as this is literally the last-ditch measure, and ketamine in my country is administered only to hospital inpatients."

• Anonymous
• November 19, 2010

"Side effects are terrible. They include diarrhea, dry mouth, in my case weight gain, it also made me agitated. I have been trying to withdraw from it and now have neuromuscular symptoms of cramping, teeth grinding, eye blinking."

• par...
• Taken for less than 1 month
• August 5, 2017

"After only a few days on Parnate, my mood declined, my sex drive totally disappeared, I lost my appetite completely, and I could only sleep 4-5 hours a night. Then my blood pressure dropped, and I wasn't able to stand much. I had heart palpitations after taking it. My mood was so dark, and my body so weak, that all I did was lie in bed for 10 days. I already have problems getting out of bed, but this made it feel impossible to move. It was absolutely miserable. I had to stop taking Parnate because it made me SO MUCH worse, and I couldn't work, eat, sleep, laugh, nothing. The reviews on here are not a balanced representation of this drug. (I have bipolar 2 depression, social anxiety, GAD, ADHD)"

• Flu...
• Taken for 1 to 6 months
• July 8, 2021

"I've been on Parnate 60 milligrams for 2 months. I take medicine for sleep. I'm unable to sleep and still have anxiety. On medication for both. Recently, my doctor decided to decrease my dose to 40 mg, saying there's a chemical in it that can cause my symptoms. Can a lower dose help these symptoms? I take Klonopin and Ambien."

• Col...
• Taken for 1 to 6 months
• April 17, 2022

"Might be good for depression if you like feeling manic and talking way more than usual. Also, the hypotension and raised liver count was alarming to say the least. If you decide to take it, make sure you get your liver checked monthly, as I was only on it for two months, thank God, and a low dose of 20 mg per day. I had to stop when my blood pressure dropped to 60 over 10, lucky I was in a hospital at the time."

• Hal...
• Taken for 6 months to 1 year
• August 28, 2016

"Everyone responds differently to medications, and no two people are alike - so I kind of find these forums as being useless (if not borderline ridiculous). But just to share my experience... I have MDD (treatment resistant) along with complex PTSD. I have tried every medication under the sun (over 90 different meds) before finally being introduced to Parnate in March of 2016. I was initially started at 10 mg and eventually moved up to 60 mg within 3-4 months. It seemed to be somewhat helpful for my depressive symptoms, yet it created so many other horrific side effects along with it that life is now worse than ever. Never have I been on a med with so many unwanted side effects. I'd rather be severely depressed any day of the week."

• Poo...
• Taken for less than 1 month
• October 30, 2021

"1983, severe anxiety, panic, and depression. Never suicidal, just crying all the time. Was forced into a psychiatric ward. Parnate was prescribed to myself and several other patients. Short story, another woman on the ward did not survive after eating aged cheese and bananas, which caused a fatal heart attack. My blood pressure plummeted to the point of my passing out. They would make me walk or run around the common room until it went up a bit and then give me my medication. Then I would pass out, and they would slap me across the face until I came to. Eventually, it put me into a coma. Doc said I was being uncooperative and required ECT. Shock treatment! I had one opportunity to escape during an outing, and I ran. Walked 13 miles to safety. Flew home to Vancouver the same day. Saw my regular doc, who immediately diagnosed severe hormone imbalance due to hysterectomy at age 27. Incompetent docs and Parnate nearly finished me!"

• Isu...
• Taken for 1 to 2 years
• March 3, 2020

"I was in acute withdrawal for five years from this dirty drug. The doctor had no clue what she was doing, nor what to do with me. I'm amazed I survived this torture. This is a dirty, dangerous drug. I now see there is 'Parnate Withdrawal Syndrome', this is an actual thing. Funny how true statistics of what this drug is doing to people aren't being collected?"

• Lol...
• October 18, 2019

"This medication, Parnate, saved my life! No other medication worked. I've been taking it for 5 years and got my life back. Please, please bring it back."

• che...
• Taken for 5 to 10 years
• April 13, 2019

"Parnate really works for my depression and makes all other drugs for depression look like a joke."

• clo...
• Taken for 10 years or more
• May 22, 2018

"Parnate is my favorite antidepressant. It took me from suicidal to happy in less than 48 hours."

• Anonymous
• Taken for 10 years or more
• June 16, 2016

"When nothing else works long term, this is the one. Pain to have to watch what you eat since it's an MAOI, but it's better than not having it!"

• Gre...
• Taken for 5 to 10 years
• July 3, 2018

"Parnate is the only antidepressant worth taking."

• JRa...
• Taken for 1 to 2 years
• April 13, 2019

"This medicine literally saved my life. I've tried them all, and only the MAOI class of drugs actually work."

• Joh...
• Taken for 5 to 10 years
• November 15, 2012

"5 years on Parnate. Have tried numerous antidepressants and psycho drugs, this is the only one that has worked. Also take 2 mg/day Suboxone, it helps somehow."

• Ork...
• November 9, 2012

"It may include some side effects, I used it, and I prefer Parnate with some side effects versus depression. That's my experience."

• mai...
• September 14, 2017

"A miracle drug for my depression!!!"

• Ros...
• January 6, 2021

"Parnate was great for depression, but it didn’t really help with anxiety at all. Coming off it has been a nightmare! Going to try Nardil next if I can track supply down."