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User Reviews for Tramadol

Also known as: Ultram, Tramadol Hydrochloride ER, ConZip Qdolo

Tramadol has an average rating of 6.8 out of 10 from a total of 1,609 ratings on Drugs.com. 60% of those users who reviewed Tramadol reported a positive effect, while 25% reported a negative effect.

Condition Avg. Rating Reviews Compare
Anxiety  Off-label
9.2
96 reviews 53 medications
Back Pain  
6.4
221 reviews 178 medications
Chronic Pain  
5.7
229 reviews 110 medications
Depression  Off-label
9.1
156 reviews 78 medications
Fibromyalgia  Off-label
7.4
140 reviews 20 medications
Obsessive Compulsive Disorder  Off-label
9.7
3 reviews 11 medications
Pain  
6.0
646 reviews 1123 medications
Restless Legs Syndrome  Off-label
8.6
110 reviews 14 medications
Syringomyelia  Off-label
6.5
3 reviews 3 medications
Vulvodynia  Off-label
9.0
5 reviews 9 medications
Summary of Tramadol reviews 6.8 1,609 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Tramadol

Sunny022 · Taken for 2 to 5 years May 28, 2021

For Depression: “This medicine is a miracle. I swear. Low dosage tramado taken as a regular antidepressant has saved my life. I used to be able to not drive and have almost seizure like problems. I wasn’t able to go out of my house or do anything. I have major social anxiety as well. This medication changed my life!!!! I mean it! I have tried every single anti depressant out there and they all make me ill. Like a zombie. They make me sad. And if you missed a dose watch out. I was on tramadol for 2 years and when I got off of it I had zero issues as well. I was on Xanax for a couple of years awhile ago and it’s what ruined me. Tramadol saved my life. Please look more into this! I’m so healthy because of this medication.”

10 / 10
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StickyGreen May 20, 2021

For Anxiety: “Tramadol. 25mg per night (half 50mg) Is the only relief from anxiety after 40 years of trying so many pills. Started after knee replacement. 18 months. No side effects. No desire to increase Although 50mg is better . Now concerned cannot prescribe for anxiety. So may have to return to daily misery. Or legal occasional 50ml doses of vodka!!”

10 / 10
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Eazy · Taken for 5 to 10 years May 12, 2021

For Depression: “Tramadol works but I get Serotonin Syndrome that made me very anxious and has toxic chemicals that are added ingredients that are hurting you and causing uneasiness and is a carcinogenic chemicals that are added ingredients for no apparent reason causing liver and kidney problems”

7 / 10
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Frequently asked questions

Quando62 · Taken for 10 years or more February 17, 2020

For Depression: “I've been prescribed EVERY anti-depressant known. I have what is knows as Treatment Resistant Depression. I stumbled across Tramadol 7 years ago and WOW, after an hour, energy, happy, feel like I can do things again after 20 years. Haven't had to increase the dosage after 7 years. This medicine has saved my life. After I take it, my wife says my eyes aren't blood shot, my mood is like it was 30 years ago, and now working full time and building a business up on the side! It's helping my Psoratic Arthritis which I had to increase to 300mg's a day since being diagnosed in 2017”

10 / 10
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Anonymous September 5, 2020

For Depression: “I recently had a prescription of Tramadol prescribed to me for severe lower back pain. I was taking an average of 300mg of Tramadol daily for several months (some days slightly more and other days none at all). It was INDESCRIBABLY successful in helping my sleep, my worries, my motivation, my energy, my anxiety, my attention, my social engagement and general happiness that I’m convinced that I could've weened off of possibly all 8 of my current psychoactive medications if I was prescribed Tramadol regularly. I came to feel even more confident about this when my prescription ran out. UNBELIEVABLY, I had absolutely no withdrawals and the only feeling I have in terms of a possible dependency is only due to how miraculously well it worked for me. It even completely eliminated my urge to drink alcohol of which I was so proud. Tramadol would be a UNIVERSAL solution for the psychological abyss that has destroyed my life since grade school.”

10 / 10
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CatMom · Taken for 1 to 2 years February 28, 2020

For Depression: “I have suffered from depression for years, and also have PTSD. Last year my depression became much, much worse. I was in tears most of the day, no positivity with anything and to the point where I was contemplating suicide. I had tried so many medications and CBT , nothing worked. I was given these tramadol for my depression and they worked within hours. I could not believe that one little tablet could have such a drastic effect. I now take 50mg in the morning and 50mg at night, I have never taken more. I have no side effects and can honestly say that Tramadol saved my life. I know that it does and will not work this way for everyone, this is just my experience with them and I am truly grateful.”

10 / 10
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Sober alcoholic May 22, 2020

For Depression: “Took first dose 2 years ago. Was 1 year sober (alcohol) and took unprescribed for pain. Took 2 weeks to go 300mg/day. 6 months later at 800mg/day; had 2 seizures. After I maintained at 600mg/day for 8 months. Was happy, energetic, and productive. Wanted out, not willing to give up benefits. Then pandemic came/shut down my source. Self-tapered, now at 100mg/day, can’t taper further without physical withdrawal. Altered mental state to point of suicidal ideations during taper. Works as antidepressant, very addicting. Wish had never taken. I read these forums when I first started experimenting and thought I could manage it. I was wrong. I guess it treats everyone a little differently, but if this post could persuade one person to get out of it before it’s too late then I have my purpose for posting. Please be very careful with this drug, I am still in so much psychological pain unlike anything I’ve experienced since getting sober.”

1 / 10
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More FAQ

rippmc November 27, 2007

Ultram (tramadol) for Pain: “I recently started to take tramdol 50mg after taking 10/325 hydrocodone for years. I have chrnonic back pain and I thought only the hydrocodone could take care of it. Well, let me tell you, this tramadol is great! It works so much better than the hydrocodone, but without getting you all buzzed up. I thinks that it's great. I was so tired of being high all the time. It's given me my brain back.”

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stephen55 March 2, 2020

For Depression: “The SNRI metabolite for Tramadol yields most of the anti-depressant action. More mental and emotional energy. Personally, I haven't noticed any addictive quality at all. I have used other hard pain relievers (Oxycontin and Fentanyl) in the past, so I know my Tramadol is not like those. Also I have used Tramadol for 8 years at 400 mg/day; I have experienced NO tolerance-building; I don't have to increase the dose. Psychiatric usefulness definitive.”

10 / 10
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Julz · Taken for 2 to 5 years March 27, 2021

For Anxiety: “For years I've been told I’m depressed & anxious but it’s more than that. As a child I suffered extreme emotional abuse but have never received any help apart from a brief period of an anti-psychotic. For at least 5 years I’ve been trying to get heard/listened to/help but nothing. I want to commit suicide every day but can’t as I have children & won't leave them with that legacy. I’m completely shut down & withdrawn & if I knew where to get hold of it would have taken heroin to just disappear for a while. It then occurred to me that tramadol is an opiate that I’ve got for back injury & 4 days ago decided to try it for my head. I can’t explain the difference I’m able to achieve things not big things but things not possible before, I’m able to watch a film & all I can think is that this is how most people feel. It’s a glorious feeling of freedom.”

10 / 10
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Bubba · Taken for 10 years or more April 13, 2021

For Anxiety: “Been on tramadol many years, The VA passed them out like candy, they put me on it for back pain, I noticed right away it gave me energy and keep me alert - it has never done anything for my pain. I still take it 15 years later every day, I still take it for energy and a little more go. I’ve spoken with many people that use it daily for the same reasons I do. Thank you for taking my comments . Bubba”

8 / 10
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Anonymous October 18, 2019

For Pain: “I have been reading a lot of the reviews on here about Tramadol. What you have to remember is that every drug will react differently to different people. Personally I think Tramadol is a good drug for me as it help with pain and increases mood elevation. I don't take it everyday I take it as a when needed basically. Taken correctly and wisely then they can be a great benefit to people who are in pain. Googling something will always give you good and bad reviews on everything. If you need them and they work for you then take them. We all need a little something with general aches and pains as we get older and if they improve your quality of live, which in my case they do, then taken correctly they will do you no harm at all. Hope this will help some people”

9 / 10
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The Grumble March 22, 2021

For Depression: “My husband of almost 30 years died 6 weeks ago, and left me without a cent, no will, in a foreign country, alone. If not for Tramadol there is no way I would survive preparing to leave here to return to my home country. Have commented here before, but in such a traumatic situation it is even more effective. Some days I up my mgs as needed, and it's honestly keeping me alive. Again I feel it is criminal that it's not prescribed as an anti depressant for those who have tried everything else with no success. It must be approved as an anti depressant!!!”

10 / 10
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gettingBetter · Taken for 1 to 2 years January 9, 2020

For Depression: “I was prescribed Tramadol 50mg a day for chronic pain and found it also cleared my foggy head and low energy. This has been a life changer for me. I've gone from sitting looking at a pile of work thinking, I just don't have the energy to do this, to wow getting everything done and more. I was not depressed, my foggy head and low energy is from chronic inflammation, arthritis, insomnia and autoimmune disorder. GP does not understand so just keep taking them for the pain with the wonderful side effect of getting my life back.”

10 / 10
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The Grumble January 21, 2021

For Depression: “It is criminal that Tramadol isn't being researched to develop it specifically for depression. I've suffered from major depressive disorder for over 30 years. Have been prescribed every antidepressant available. Some worked for a while, some not at all. I was given Tramadol for something else and within an hour I felt pretty much alive again. For me it's a miracle drug. I've been going through a really horrific time the last couple of months, and I believe I know I wouldn't have got through it without Tramadol. I take two 50mg capsules a day. There are absolutely no negative side effects. With depression being one of the worst diseases in the world, I find it incomprehensible that it is not being widely used to help the hundreds of millions in terrible distress. Even if it didn't help every person, I know it would help millions. It can be life changing, and it's very inexpensive where I am.”

10 / 10
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Anno · Taken for 5 to 10 years January 26, 2021

For Depression: “Tramadol works GREAT for depression. With so many other people claiming this I don’t understand why it isn’t prescribed more for depression. It is very weak for helping with pain but works wonders with depression. I took it for years. Have now been off for 2 years due to moving to TN and unsure where I could go. Apparently there is a drug problem here and you bring up anything regarding any pain medication and they think you are an addict lol. I took 50mg twice daily for years with no need to increase my dosage. I had zero withdrawals when I stopped. But recently have been very depressed. Sucks they will not listen to us and help us.”

10 / 10
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Anonymous · Taken for 5 to 10 years November 22, 2019

For Depression: “I just wanted to do a follow up , from a previous post about Tram for pain. So let me just say Tram is a depression, anxiety killer. Point blank. There is not another drug like it. The chemical make up is so unique because, yes it does help with pain. But it will absolutely give you a new lease on life if you are depressed. But please, please use with caution, never ever take more than prescribed. Because let me tell you, If you ever have to quit the Tram. The withdrawals are a living hell. And that is putting it mild. There are two classes of people I would recommend Tram too. One with severe depression, that other SSRI did not work. And those who plan on staying on Tram for life. And not conning off. If you ever have to go without for couple days. You will see what I mean. Great drug, lifesaver in some cases. But proceed with caution. Please”

10 / 10
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El July 29, 2019

For Depression: “After 45 years of having depression, I have realized that tramadol takes away the symptoms of depression better than antidepressants. I consider myself an expert in depression because I’ve survived this long and I’m still alive. No psychologist or psychiatrist in the world that knows this illness better than a person who’s had it all their lives. Reading the comments here it’s very sad to me that the organisation has so little concern for the welfare of the people who need this drug that they have demonized it and put it in the same category as heroin. If you are taking 50 mg a day of tramadol you can quit immediately. It is such a low dose that it’s sold in many countries (like Mexico) over the counter. Not only is our healthcare too expensive, we can’t even get treated with drugs that work. I hope doctors in America start to listen to their patients and read the testimonies here instead of what is dictated as real. It’s infuriating.”

10 / 10
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Karen · Taken for 1 to 2 years August 24, 2019

For Depression: “I have suffered with Depression for 25 yrs and have tried every medication that has been made! They all either didn't work or had horrible side effects not making it worth taking. I was prescribed Tramadol for chronic headaches and it has changed my life as it got rid of my depression . I take it about an hour before I get up. I get up wanting to live my life and be around people! I have lost 20lbs because I want to do things and exercise. I eat healthy now and have this incredible drive for life! It has saved my life and my marriage. I have recently moved and have to find a new doctor and I am petrified that I won't be able to get my prescription. ”

10 / 10
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Sky · Taken for 1 to 6 months September 15, 2019

For Anxiety: “Omg!! Wow! I started taking Tramadol for pain for my autoimmune condition and RA and I kept noticing that my pain was at a minimum. I USUALLY have a SEVERE case of anxiety and fatigue and probably a little depressed too. Welp, I started asking my family..."WHY DO I FEEL SO GOOD?" It is definitely a HUGE change for me but I couldn't figure out "Why". Finally,I narrowed it down to Tramadol by not taking it for a day. I went right back to my feeling horrible self...so I took it the next day...and HOLY CRAP! My anxiety is low, I feel GOOD and I am sold! I will now gladly take this instead of suffering so badly. So thankful I realized this side effect. It has helped me so much!”

10 / 10
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Telemark1 September 26, 2020

For Anxiety: “Like so many others, I discovered the anti-anxiety and anti-OCD effects of Tramadol. Tramadol was originally prescribed after I moved from opium derived drugs to Tramadol, I noticed a much calmer sense of myself and attitude. I have suffered from anxiety and obsessive-compulsive behaviors for three decades. I take 50 mg in the morning. I have been doing this now for 21 months and my level of agitation is significantly diminished. I don't drink now nor engage in other self-destructive and obsessive behaviors. On occasion, I will take a second 50 mg late afternoon if I have a stressful or intense meeting or work engagement upcoming. I long ago stopped getting any pain relief from this drug. I have to argue with my primary physician for refills. I test the effects by stopping the drug for 1-3 weeks every 5-6 months. Eventually, the anxiety returns and it becomes as real as the past. I have never suffered any withdrawals coming off of 50-100 mg daily dose.”

10 / 10
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Anonymous February 8, 2009

Ultram (tramadol) for Pain: “I was prescribed Tramadol after a herniated disc in my lower back and 50mg gives me great pain relief for about 6 hours. If the pain is really bad then 100mg works wonders as well. I have not experienced any negative side effects. This medicine also puts me in a GREAT mood and helps with some symptoms of depression which makes it much easier to get through the day. I would recommend Tramadol to anyone experiencing pain.”

10 / 10
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Robot1 July 2, 2019

For Depression: “I was gonna respond to the people saying Tram is a life saver. Well , it can be, but be cautious because it will be the hardest drug you have ever tried to quit. From 8 years of experience. I take 400 mg a day. I have 2 bad vertebrae , stenosis, degenerative disc. Nerve compression . Tram was prescribed for the pain. But it took only a week for me to know something was different After years of Anxiety, depression. Suicidal thoughts. It all ended by the end of that week. There is no other medicine made to do what Tram does. None. Effexor comes the closest. But Tram blows it out of the water. Tram never makes you have that high spacey feeling, just a relief from the panic, depressed. I don’t ever plan on quitting. Like I said earlier, you better plan on being on Tram for the long haul, because their is no going back, once you start. Your depression and Anxiety, pain will be unbearable. So please use caution and count the cost of taking Tram. It is a life saver. Until you go off of it.”

10 / 10
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Diego227 · Taken for 6 months to 1 year April 1, 2020

For Anxiety: “Tramadol helped me tremendously to feel more present and thus less anxious. It is a good idea to expose people to tramadol in low to moderate dosage. Psychiatrists are under pressure to exclude it and are backed by "research" funded by pharma companies that recommend "their" drugs. Where is the money, you ask? Nobody wants to hear about how tramadol helped your depression and or anxiety. Pharma doesn't send your psychiatrist to Maui to prescribe tramadol for your depression. It is sad that such a powerful medication, not less habitual or addictive than the other stuff, is labeled as addictive, habit forming and plain dangerous. Those who know tramadol (up to 100 mg a day, or just 50mg) will attest to its life changing qualities. Much less anxiety and much better spirits.”

10 / 10
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Shellfish81 · Taken for 1 to 2 years December 21, 2020

For Depression: “I take tramadol for lower pain, however, I use it mainly for depression and anxiety. It works better than any antidepressant I’ve ever taken. I’m on the 50mg instant release tablets, and I take it up to 4 times a day. I keep my dose between 100mg-200mg a day. I don’t overtake it, as tolerance builds up quickly. In reference to the people who warned that this drug is very addictive, and that it shouldn’t be prescribed for depression because of that, I have to say, regular antidepressants are just as bad if you quit taking them (MAJOR withdrawals, brain zaps, etc) ...so prescribing tramadol shouldn’t be any different. This drug has done wonders for me, and I’m so happy I was able to find a doctor who would write it for me.”

10 / 10
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Jame583 January 13, 2020

For Depression: “I actually found tramadol worked for depression while being treated for pain in back. Noticed how great I began to feel. No depression and actually felt like myself for the first time in years. So I actually had a long talk with my psychiatrist and after showing him several articles from various sources, the NEJM for one and much more and telling him of my experience why using it for pain and how it uplifted me he finally agreed to it on a trial bases. I haven’t looked back since. Now I still take my other depression meds. The tramadol is in additional drug. Yes it is addictive and no I don’t care. Your body will start showing signs of tolerance and you made need to adjust your dosage over time. I recommend starting on the lowest dosage that works for this reason. Do not abuse it because it makes you feel high or buzzed. This will increase the quickness in tolerance and you will eventually run in to the ceiling on daily maximum dosage”

9 / 10
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Jake · Taken for 1 to 6 months December 14, 2019

For Depression: “I’m using tramadol off label for depression as well as chronic back pain, just 50 to 100 mg daily. It doesn't have any of the nasty side effects like all of the typical antidepressants. I virtually have no side effects from it. It’s a godsend for me, it cures anxiety and lifts my mood.”

10 / 10
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Becky28 December 23, 2019

For Depression: “I am a single mother of 3 boys one who has autism and some days we're soooo hard that I was only just coping. I had anxiety and depression. I was prescribed me some tramadol for a headache I had and let's just say in about 40 mins I went from feeling anxious, stressed and angry to happy, energetic and playing with my children. Complete life changer for me for the better. My quality of life improved along with my families as now they have a mother who is happy, patient and calm. I've been on tramadol for about 7 years with no complications. At most I have gone up to on "bad" days was 800mg but now I taper down or have a couple of days break so my tolerance does not build, because obviously like other pills the withdrawal is awful. But so worth it for me ”

10 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.