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Nucynta ER User Reviews & Ratings (Page 2)

Nucynta ER has an average rating of 7.2 out of 10 from a total of 81 reviews on Drugs.com. 67% of reviewers reported a positive experience, while 19% reported a negative experience.

Reviews for Nucynta ER

Commonly mentioned side effects
  • Anonymous
  • Taken for 1 to 6 months
  • September 24, 2012

For Pain "After 2 years on Percocet for back pain, my surgeon recommended I see a pain specialist. The doctor prescribed Nucynta ER and completely took me off the Percocet. The first 5 days were awful. I was taking 50 mg twice a day to get it in my system, then taking 150 mg twice daily as my regular routine. I didn't think it worked at all and felt terrible because of the withdrawal from Percocet. I stuck with it and am glad I did. My mornings are much better because I'm in almost no pain, whereas before, mornings were the worst. It has much less adverse effects on my short-term memory, ability to focus, and ability to function more at the workplace (I'm a math teacher) than when I was taking Percocet. The negatives are that I still have evening pain."

8 / 10
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  • Mar...
  • February 23, 2019

For Pain "I have been on Nucynta ER since around 2013. Had a bad car accident in 2011, and the opiates alone were not enough. My lower back discs L2-S1 are bad along with my facet joints, spine, and nerve damage in my left leg and other issues. My doctor started me on 250 mg, which helped. The pain was better, and I still stayed on my hydrocodone 10 mg 2-3 times a day. After a couple of years, I felt I wanted to go off this drug. I did not like the foggy feeling. I went down to 150 mg. It took my body one year to adjust to 200 mg a day! The first two weeks were horrible! This medicine will not make you 'high' like Percocets or oxycodone. It just made my body crawl, and I could not sleep. It gives me hot flashes, makes me tired, and affects my memory. I am still on the 150 mg and searching for another opioid to replace it with. I just do not want to go on something that will give me the same side effects."

8 / 10
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  • PES...
  • Taken for 1 to 6 months
  • August 7, 2018

For Pain "I have had multiple different surgeries and live with chronic pain. I've been taking three Percocet 5-325 mg per day. The pain control would only last for around 3-5 hours. The constipation that comes along with the above med was unreal. I then ended up forming stage three hemorrhoids and had to have a hemorrhoidectomy, which was the worst! The pain medicine also made my depression worse, which I did not need! My pain clinic doctor recommended Nucynta ER 50 mg every twelve hours. There were two benefits in taking Nucynta ER 50 mg: first, it was around-the-clock pain control; and secondly, it eliminated my hard stool and constipation. It was increased to 100 mg because of my pain levels. I was still dealing with breakthrough pain and was given oxycodone 5 mg, but once again, it caused more depression and constipation immediately! I’m going to have to stop taking the oxycodone and talk to my pain clinic doctor about increasing my dosage of Nucynta to 150 mg twice per day."

10 / 10
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32 Report

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Frequently asked questions

  • Mns...
  • Taken for 2 to 5 years
  • November 1, 2017

For Pain "Have been taking Nucynta ER for nearly four years. Have degenerative disc disease and the remnants of seven torn discs in mid-thoracic to lumbar and a cervical bulging disc. Have an old compression fracture in thoracic, all caused by a 2009 accident, the torn discs are now practically non-existent and near bone to bone at several levels. Nucynta has changed my life. After taking Norcos and Roxy and others, due to no insurance at the beginning, landed on Methadone as it was affordable. Three years with Nucynta now, using nothing for breakthrough, would rather deal with a little pain than be on more than I have to. Can think, am back to work and providing for my family! It doesn’t fix everything, but has literally changed my life!"

8 / 10
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  • amy...
  • December 9, 2011

For Pain "I just started 150 mg Nucynta ER. I have been on almost every pain medicine in existence. Aside from the cost of $375 for 60 pills, I believe it is working quite well. I have been on long-term pain management for 12 years. Since this medicine is new, there is not much information about it online. I am hoping to hear more success stories and other people's opinions soon."

8 / 10
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  • Tin...
  • Taken for 2 to 5 years
  • February 21, 2018

For Pain "Nucynta is a miracle drug for me. I have a condition that caused defects in almost every vertebra, rib, and more. I’ve been in severe pain all my life and tried almost every pain med on the market with little relief and horrible side effects. I’ve been on Nucynta for five years, and nothing else comes close in terms of pain relief. Before Nucynta, I was in bed almost 24/7 and required help dressing, washing, etc. Now I can do my own care, and I can go out on good days. The only side effects for me are increased heart rate and short-term memory issues when the IR medication “peaks.” I have no GI issues, and I am alert and clearheaded. My dose is 150 mg ER 2x a day and 100 mg IR 3x a day, and it hasn’t changed in 3 years. I don’t build a tolerance like I did with other opioids. When I first started, I got serotonin syndrome, so they took me off of all other serotonin drugs. I haven’t had any issues since, but it is a dangerous reaction, so people should know the symptoms."

10 / 10
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  • Dis...
  • Taken for less than 1 month
  • December 10, 2019

For Pain "Just filled my first Nucynta 50 mg X2! Have had experience with Opana, Oxycodone, Morphine, and many more opiate-type meds. I have CIPD with diabetic neuropathy as well as chronic pain! I initially am feeling some areas of pain go away! I’m going to wait longer to share updates, but am optimistic!"

9 / 10
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  • Ace...
  • August 13, 2016

For Pain "Saw pain. Doc went over all my test, MRI results, and did an exam. Should have known he was a Nucynta ER pusher by all the posters in the office. Started me off at 150 mg x2 a day, and in the beginning, it seemed to work along with Dilaudid for BT pain. Saw the Doc 2 days before surgery, and 3 months on Nucynta ER, I told him it wasn't really working for me. He said, well, let's UP your dose to 200 mg 2x a day. I had surgery, no issues. Until I started back on the Nucynta ER. I had hallucinations, loss of memory, and violent rage. I don't remember the last two days I was taking the medication. I ended up in the ER 3 days after spine surgery because I went into a fit of rage. Pain Doc was called, he said it was the Nucynta and to stop taking it. Bad drug."

4 / 10
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  • Sad...
  • Taken for less than 1 month
  • February 6, 2015

For Pain "I take 50 mg ER tablet 2x daily, once every 12 hours. It gives me an uncomfortable adrenaline rush every so often, but otherwise, definitely controls my pain levels. I have scoliosis. It is more of nerves in muscle pain and exhaustion."

10 / 10
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  • mmr...
  • June 5, 2015

For Pain "I was taking 30 - 40 mg hydrocodone and 300 mg tramadol a day for lumbar spinal stenosis. I have 4 herniated disks, so L2. The hydrocodone was just scratching the surface of my pain. My doctor put me on 100 mg Nucynta ER, twice a day, and it has been so much better. Had to stop the tramadol. Still taking the hydrocodone, need to adjust the dose, but it has been much better, almost no side effects. They do only seem to last for 8 hours, so I will talk to my doctor about doing 150 mg three times a day."

8 / 10
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  • SAS...
  • January 27, 2018

For Pain "I love Nucynta ER. I take different pain meds for different kinds of pain. Nucynta was prescribed when I told my doctor I couldn't stand my legs anymore. My legs felt like huge, heavy, painful, petrified stumps. I couldn't sleep, and other pain meds didn't touch the pain in my legs. Nucynta takes this pain away. And when the pharmacy couldn't get the medication for a week, there were no withdrawal problems, except the leg pain came back. This year I am afraid, as no one is covering Nucynta ER. I chose a Part D plan that showed online Nucynta ER was covered. But now they are saying it's not in their new paper formulary. Back to the search, and back to leg pain."

10 / 10
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  • Rub...
  • Taken for 6 months to 1 year
  • August 5, 2017

For Pain "I have chronic idiopathic pancreatitis, allodynia, gastroparesis, and tarsal tunnel syndrome. I was also just recently tested for lupus. I was taking Norco (hydrocodone/acetaminophen) for a year until my new doctor realized it was making my GI issues worse. We switched to Nucynta ER 150 mg/BID and Nucynta IR 75 mg for breakthrough. While they worked the first few months, I seem to be building a tolerance. I feel like the ER takes the edge off when my pain is between 4-5. But both IR and ER cause excessive sweating. I mean, there are days I have to change clothes multiple times daily. It's embarrassing. But the Nucynta does not have any of the GI side effects (constipation, namely) that other narcotics do."

7 / 10
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  • Joh...
  • Taken for 2 to 5 years
  • December 15, 2019

For Pain "I started on 50 mg of Nucynta with 4 of the 5/325 mg Vicodin daily. I had carpal tunnel, rotator cuff surgery, and neck surgery, all related to work. My pain doctor upped my dosage to 100 mg Nucynta ER daily. Taking it with Vicodin during the day, it seems to work okay. I get the sharp nerve pain on occasion from my neck into my arms at times. As a whole, it works okay. Sometimes, with chronic pain, one has to search for what works best for that person. We are all different."

8 / 10
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  • Anonymous
  • Taken for less than 1 month
  • May 29, 2016

For Pain "This drug gave me a bad reaction from the very first dose. My doctor thinks I had serotonin syndrome from taking this with an antidepressant. I got a fast heart rate, flushed face, restless, like taking some kind of stimulant. They cut my antidepressant dose in half, which helped some, but I still couldn't stand the side effects. Lots of nausea too. Pain relief was okay, but not great."

2 / 10
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  • HJB...
  • February 17, 2013

For Pain "My pain level was 10, most of the pain from severe back problems down my left leg into my foot. After many medicines, which made me groggy, sick to my stomach, and not able to really function. My doctor prescribed Nucynta ER. I can function without most side effects. The only side effect seemed to be like a light recall problem when carrying on a conversation. Example: names, places, times. I could go all around what I wanted to say, then finally it would come to me."

10 / 10
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  • L2a...
  • Taken for 6 months to 1 year
  • January 5, 2020

For Pain "After having a benign brain tumor removed, I began suffering from horrible headaches and seizures. I fell and fractured 5 ribs and collapsed my lung. That’s when I was diagnosed with cluster headaches. I have tried so many different medications and treatments, nerve blocks, infusions, and ablation. My pain management doctor started me on Nucynta ER 250 2x daily, and when I have breakthrough pain, I have 2-50 mg I can take to manage the pain. It’s tolerable, and I do not wake up in agony anymore. I also use Emgality, a migraine medication, monthly. The combination of medications is working better than anything else. The only thing I can say is this medication is the most expensive medication I have ever paid for. I wonder what people with no insurance would do."

8 / 10
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  • Gre...
  • Taken for 2 to 5 years
  • July 30, 2015

For Diabetic Peripheral Neuropathy "Been on Nucynta for a while (3-4 years) for very bad neuropathy pain. Have taken it with Norco every 4 to 5 hours - has little to no side effects, within an hour after taking I can feel the pain go almost all away, can function great at work - no side effects to speak of, no problems falling asleep, use 'Kerasal NeuroCream' on hands and feet at night dulls pain enough for me to fall asleep."

10 / 10
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  • Ste...
  • Taken for less than 1 month
  • April 19, 2016

For Pain "I've got very severe osteoarthritis on 100% of my spine. A ruptured disk at L2 that even the best neurosurgeons told me they couldn't fix because of all the holes in my vertebrae from the osteoarthritis, so fusion won't work either. So, I've been on 15 mg of Roxicodone 4 times a day for the last 6 years. Today, my doctor and I decided to try a combo of 2 drugs, Nucynta 100 mg and Hysingla ER 60 mg. Haven't taken any Roxi today just to see if the Nucynta ER helps any, and it does, but not as good as the Roxi. Having to wait on the Hysingla ER until Friday. I'll report back on this after I get those and use them for a week."

7 / 10
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  • Anonymous
  • April 23, 2013

For Pain "I have nerve damage due to spinal cord surgery. I have tried several long-term and short-term pain medications, and everything made me tired that I could not work while taking the medication. The pain doctor then put me on Nucynta, which I take at night, and it works wonderfully. I still take pain medication during the day for breakthrough pain, as I cannot take the Nucynta while I am working."

8 / 10
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  • Wam...
  • Taken for 1 to 6 months
  • December 8, 2019

For Pain "Multiple herniated discs, severe osteoarthritis in my spine, and severe degenerative disc disease, my neck and lower back are the worst for me. I've tried percs, Butrans 20 mg patches, and now Nucynta 400 mg a day. Been on it for 6 months now. Helps, but certainly not a cure-all! The breakthrough pain is awful, and all I can take for it is arthritic acetaminophen, which does nothing. Don't miss the constipation, buzz, or nausea of the other options. Biggest downside is it stops all ambition and drive!"

7 / 10
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  • Ita...
  • July 22, 2016

For Diabetic Peripheral Neuropathy "My stepdad was using this medication for less than two weeks before the pill itself killed him, proof is in the death certificate. He was not abusing either. He complained from day one of taking it of many side effects. Sleeplessness, dizziness, trouble urinating, hallucinations, still felt pain, couldn't stand without falling, etc. He asked his doctor to be off the pill, and they told him to wait until they see him the following month. Also, fault in their practice too."

1 / 10
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  • Ups...
  • August 28, 2017

For Pain "Good pain med, took a few days to get used to it. I'm on the max dose 600 mg/day. I got quite dizzy at first, trying to figure out when to take my breakthrough meds. Very little highs and lows for me, that is important, not like the Percocets I used to take."

8 / 10
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  • Ang...
  • Taken for less than 1 month
  • November 30, 2016

For Pain "This medicine made me dizzy and didn't help me with the pain at all. I was vomiting after about six hours. This is nothing like I'm used to. There is something in this medicine that isn't good, and I wouldn't recommend it to anyone."

2 / 10
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  • Fli...
  • July 31, 2014

For Pain "I have been in severe pain for 10 years. I had a 360 back surgery done on the 18th, the pain is so bad that I can hardly stand it. My surgeon sent me to a pain management doctor, and he put me on this Nucynta ER 50 mg twice a day. I do not sleep, I wake up in the wee hours of the morning just screaming in pain. The pain management doctor said to give it time to work. I have taken it for two days, and no relief is in sight. I have called and called, I am supposed to wait until Friday and call again, but I cannot take much more of this pain I am in."

1 / 10
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  • Dou...
  • Taken for less than 1 month
  • December 16, 2016

For Pain "My anesthesiologist prescribed me Belbuca for the RSD. No relief and a migraine to boot. So about two weeks ago, he switched me to Nucynta ER 100 bid with a max of 4 Norco 7.5/325 for breakthrough pain daily. I am waiting for the intrathecal pain pump. My insurance company denied the procedure, saying they needed more info, so now they are going to have a 'peer to peer' TODAY with the spinal surgeon. I am tired of all the different medications, the side effects, and feeling like a lab rat. Have maxed out the lumbar punctures too as minimal relief was achieved. I am fortunate to have a fantastic anesthesiologist (pain management) who genuinely cares about me and the situation I am in. Nucynta seems to give little relief. Will take any I can get."

6 / 10
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