S-adenosylmethionine User Reviews & Ratings (Page 2)

• Ken...
• July 28, 2020

For Depression "Took s-adenosylmethionine, and it makes me feel okay for around an hour, then the rest of the day is filled with heightened anxiety. Have tried it several times, and the effect is always the same. Not for me."

• Kat...
• Taken for 10 years or more
• June 6, 2021

For Depression "Depression and anxiety plagued me until taking this 15 years ago. First heard about Sam-E (that's its short name) on PBS. It's a strong supplement one needs to understand. I began at 400 mg daily, then went to 600 mg, which helped, but ultimately I landed at 800 mg - perfect. (Shocked to hear people start above 1000 mg. Seems like too much too soon from my research, but I'm no doc!) Fortunately, no side effects for me. It can interfere with falling asleep, so always take it in the morning. Also, take it on an empty stomach, then no food for 30 minutes. Make this med routine; don't stop it cold turkey because of possible withdrawal symptoms - quick onset depression or anxiety attacks. Take the enteric-coated version only. Sam-E is pricey, so take advantage of the drug stores' buy-a-box, get-a-box-free. This has been used in Europe for decades, long before in the States. When I researched it 15 years ago, all info and reviews were from Europe - great info!"

• 302...
• July 7, 2017

For Depression "I sometimes have mood problems, which I believe are related to blood sugar issues because when I am careful to not consume refined sugars, I feel much better. I also experience joint pain because of the decades of physical labor. I have been taking SAMe for more than 15 years, 200 mg every morning before breakfast. It affects me in a subtle way. It seems to pick my mood up a bit. I can't take it at night before I go to bed because it makes my brain overactive and I can't sleep. Lately, I've been searching the Internet for information about the long-term side effects because I am a little worried about taking this substance regularly for such an extended period of time. The dosage is low (200 mg daily), but still, 15 years is a long time."

• Car...
• March 13, 2021

For Depression "Best supplement ever for my type of depression (dysthymia/anxiety/ADD; the type where you have no motivation, can sleep all day instead of insomnia, etc.). I also have mild/moderate CFS. It's like I'm missing this in my body. Works in 1 week for me, but I am very sensitive. 200 doesn't do a lot, 1000 made me very anxious, 400-600 seems to be the sweet spot. HOWEVER :-( : After 6 weeks or so, the antidepressant effect goes away. Also, after a few months of use, I started to feel nauseous (I take it in the morning before food, and for the first 2 hours my stomach is a bit upset). When I stopped once, I felt awful, btw. I would highly recommend tapering off. Nevertheless, I can't live without this anymore. It still works amazingly for my ADD/concentration, and I am less lethargic, need less sleep. My next step is trying to add saffron to the mix. I think it works best for people who need both serotonin and dopamine/norepinephrine. I take Now Foods brand."

• sou...
• Taken for 1 to 6 months
• February 18, 2021

For Depression "I've been taking SAM-e for two months now and noticed a slight elevation in my mood. I also want to support my liver function, which it claims to do. But after taking 800 mg once a day for eight weeks, my right kidney is in pain, and I feel worse than before taking it. Be careful with this supplement! I never had kidney issues before taking it."

• jc1...
• Taken for less than 1 month
• September 29, 2021

S-adenosylmethionine for Herbal Supplementation "I have moderate depression, mostly seasonal (Seasonal Affective Disorder), but also bouts outside of winter. I also have moderate GAD (Generalized Anxiety Disorder). I'm a research 'o'holic and tried many supplements for various conditions. I started enteric-coated SAMe 400mg total at 200mg twice a day (once in the morning, once at lunch) for a week. Didn't notice much. I started low to ensure no stomach issues. I read research that the 800mg-1,600mg was most common in studies, so I upped the dose to 400mg twice a day = 800mg. That made the difference. More energy, elevated mood, more motivation, but after about a week on 800mg a day, I started to notice I was feeling TOO 'up' and started to have moderate anxious feelings, borderline full-blown anxiety, all day. Also had consistent negative (aka 'bad') dreams. So thanks, but no thanks, SAMe. Going to switch to Acetyl L-Carnitine (the concerns about TMAO and heart disease have since been debunked in other studies) and see how that goes."

• mma...
• September 18, 2020

For Depression "I tried SAM-e a few years ago after my dad died. (200-400 mg morning huge glass of water) It was amazing, worked really quick, and I found the years of intermittent depression vanished (took for a few months). I weaned off and was fine until I started perimenopause symptoms, so I thought I would try again and see if it would help the lows and highs. It's only been a week, and it has stabilized them (also taking 300 mg magnesium). It's also helped my joint pain significantly, but it hasn't helped the anxiety, and I have bad bloating. The first few days, I was agitated, dizzy, and felt a bit manic, but I remember that from last time, and it settled now after a week. I am going to keep taking it for the joint pain and the depression, even though it hasn't helped the anxiety. I just hope the bloating calms down, as I feel like it puts pressure on my heart."

• Chr...
• Taken for 2 to 5 years
• August 6, 2024

S-adenosylmethionine for Herbal Supplementation "I had been taking SAMe for years with virtually no side effects. I took 1 400 mg enteric-coated tablet in the morning on an empty stomach. I definitely felt a positive benefit from taking it, even at that low dose. Recently, I decided to stop taking it due to uncertainty about the long-term effects and, honestly, also about the cost. After a month or so after stopping, I noticed depressive symptoms returning, such as agitation, indecision, heaviness, etc. I am going to start taking it again, even though I still don't know about any long-term effects because, as anyone who has suffered from depression knows, relief from it is a real blessing."

• sb4...
• March 27, 2014

For Depression "I had read up on this drug before using it, and multiple sources stated that it could help with depression. I was on it for about a week before I noticed any positive changes in my mood, so I can attest to its effectiveness against combating depression. The downside for this drug is that I experienced all of the 'less' severe symptoms, and I must say that they were pretty severe. On the second day of taking the drug, I experienced dizziness to the point that I fainted in public, and that very same day I had a horrible bout of nausea and vomiting. I vomited to the point that there was nothing left in my stomach, and I was just vomiting bile and blood from my raw throat. This works great for depression, but I'm going to use something else."

• jas...
• Taken for 1 to 6 months
• June 1, 2021

For Osteoarthritis "Used 1200 mg a day for a month. Had wild dreams starting week three. No noticeable arthritis relief. Reduced to 400 mg after week four. Still very bad dreams and no arthritis help. Stopped after six weeks."

• geo...
• Taken for 2 to 5 years
• July 19, 2013

For Depression "I have had noticeable benefits with mood support in the years that I have been on and off of SAMe. It has helped me to be less vulnerable to depression and to better control my anxiety. I took 200 mg each morning for a few years and have now been taking 400 mg each morning for a few months now. I have not had any joint problems, but I partially attribute that to SAMe (as a preventative). I have had no side effects, and my only discouraging factor was cost, as it is not covered by insurance and is expensive at many retail outlets. I found it online for a much more affordable rate and have been able to take it consistently now."

• rox...
• March 9, 2010

For Osteoarthritis "During my treatment of depression and RA, it seemed all the medicines stopped working at the same time. I was taking Cymbalta. I tapered off of it and tried Pristiq, which worked horribly. I stopped taking them all and researched natural remedies for depression, and came across lithium orotate and SAMe. I have been taking both for a couple of months now, it seems to keep me level and out of the depressed state that I was in, so for now, it seems to be working."

• Tej...
• Taken for 5 to 10 years
• July 8, 2022

For Depression "No negative effects. Gradual and subtle improvement of moderate to severe depression. I started to think I was just getting better, and so I tapered back from three 400 mg per day to one or two, and I started to go back into the dark place. I'm not giddy with joy by taking 1,200 mg a day, but I am highly functioning and moderately happy."

• sna...
• February 7, 2013

For Depression "I have been depressed for almost 3 years. I feel myself fine only a couple of hours a week, and it feels good, so I have been making my research on fighting the disease without antidepressants. So, I work out, eat right, and only eat fresh, non-processed food. I made me feel less pain, and it is so delightful, but I still cannot be funny, can't just have a casual talk, and I can't learn or retell the content of what I just read. Today I started taking S-adenosylmethionine. After taking 2 200mg pills, I ate a little and went to bed, but when I woke up, I felt like I wanted to be doing something. I feel less tension, and I hope the result will repeat tomorrow. I also read that fixing your memory can help you fight depression. So, try Vinpocetine Huperzin-a."

• lee...
• Taken for less than 1 month
• April 13, 2023

S-adenosylmethionine for Depression "SAMe worked fast to elevate depression, but I am worried a placebo effect may be happening in that the speed of this supplement, as mentioned by many reviewers! I am not convinced it has a placebo effect, as it helps me. I will keep trying it and decide for sure if it is imaginary results we feel or the real thing."

• Buf...
• March 31, 2014

"SAMe works fast. I feel some relief the first day I take it. My mom passed away, and I was having trouble with depression. It takes the edge off the depression so I can function. However, after a few months, I started to get nerve pain. Sharp, stabbing pain (like a bee sting) in extremities - I quit the med, and the pain slowly went away. It took a few weeks to be completely gone."

• Car...
• Taken for 1 to 6 months
• October 1, 2023

For Osteoarthritis "I am a 75-year-old active woman. My doctor recommended I take 400 mg of SAMe daily for hip and leg pain. I have been taking it for 3 months, and it has worked wonders for me. I have very little pain now when I take my daily walks or garden, and I seem to have more energy. I don't have side effects from it, which I had when I took OTC pain medications, such as bad dreams and stomach upset."

• mem...
• Taken for less than 1 month
• May 5, 2024

For Depression "Going through a breakup. This helped me stay strong and have clarity about my relationship, and that leaving was the best course of action for my health and sanity. Only negative is the gas and stomach pains. Whatever you do, don't have food in your stomach at all. Maybe a cup of tea and loads of water. First thing in the morning and don't eat until the afternoon at the earliest. I think dairy makes it the worst so probably avoid dairy at all costs. But other than that inconvenience duck me if it doesn't make life easier and rough patches a breeze."

• CJA...
• Taken for 6 months to 1 year
• February 12, 2025

S-adenosylmethionine for Herbal Supplementation "I have tried literally dozens of natural approaches to combat depression, and nothing has ever worked as well as SAMe. I was even on Cymbalta for a few years, and while it helped in a dulling way, SAMe is still far better. I only take it when I feel I need it due to the cost, with the wintertime being a must. But it's amazing that when I take it after time away, I feel an immediate relief in my head, best described as a clearness and a renewed sense of hope. This, in turn, makes me more productive and happy to be at my work. It's like a stimulant when you are the sort of depressed that just wants to sleep the entire weekend away from work. Still, I try to work on my own skillset and only use it periodically as needed, but considering the ugliness of my depression, I'm sure happy to have it."

• CJT...
• Taken for less than 1 month
• December 23, 2024

For Depression "I sometimes fall into a hopeless depression. I am, however, trying everything in my power to stay off of pharmaceutical antidepressants. I've taken SAMe on two separate occasions, and the results repeated themselves. The good is that it was an immediate relief. I felt instantly better in the first few days of taking it 2x a day at 400 mg. The bad is that after those few days, while continuing to take it, I took on bad side effects. My moods went totally out of flux. I normally don't drink, but this drug puts the craving in me, and I can't stop. If you are someone who is prone to overdrinking, I would tread lightly with this drug. Personally, I have found it overall unsustainable to my health, and I'm looking at other strategies besides SAMe."

• Hey...
• Taken for 1 to 6 months
• April 30, 2015

S-adenosylmethionine for Osteoarthritis "It works, but side effects with digestion are so bad. Had to stop it."

• Rig...
• Taken for less than 1 month
• January 22, 2023

S-adenosylmethionine "I took SAMe for three days and ended up in the emergency room with dizziness so bad I couldn't safely walk. I also felt nauseous and vomited. This medication is not for me."