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Roflumilast topical User Reviews & Ratings (Page 2)

Brand names: Zoryve, Zoryve Foam

Roflumilast topical has an average rating of 8.7 out of 10 from a total of 57 reviews on Drugs.com. 81% of reviewers reported a positive experience, while 0% reported a negative experience.

Reviews for Roflumilast topical

Commonly mentioned side effects
  • Pat...
  • Taken for 1 to 6 months
  • December 17, 2023

For Plaque Psoriasis "I have been using it for a month and a half and my psoriasis has cleared up completely. I have had minor side effects of urinary incontinence, but it's definitely worth the inconvenience to finally have my psoriasis under control."

10 / 10
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  • Wor...
  • Taken for less than 1 month
  • January 31, 2025

For Plaque Psoriasis "I have been dealing with plaque psoriasis on my scalp for over 15 years. After just 4 days, Zoryve foam completely cleared it up, and I was thrilled! On day 9, and for the past week, I have had diarrhea, other GI issues, and some random headaches. Had no idea this was a common side effect of this medication until I researched it online. Very disappointed. Not worth the side effects for me. Cortizone solution has helped in the past, but not nearly as effective as Zoryve. For anyone out there with scalp psoriasis that can't tolerate the side effects, I have found that hair oils help greatly, but it does take time and effort to use."

7 / 10
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  • Tah...
  • Taken for less than 1 month
  • January 24, 2025

"I just started on Zoryve yesterday to help with some mild eczema on my eyelids. The cream is easy to spread using my fingertip, but as soon as I put it on, there is a mild stinging that goes away in about 10 minutes. One of the side effects is sleeplessness and nausea, and I felt both mildly. When I woke up in the morning, I did not feel the urge to itch my eyelids, and the rough, scaly skin was no longer there. I used a cold compress on my eyes for about 20 seconds before washing my face, and that helped too. I am not using any eye shadow until the symptoms are gone."

7 / 10
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  • Lau...
  • Taken for less than 1 month
  • September 28, 2024

For Plaque Psoriasis "My dermatologist prescribed Zoryve for a patch of dry, itchy scalp that I had been dealing with for months. Within 3-4 days of use, the dry patch and white scales were completely gone. I had tried other options, but nothing worked. Very easy to use. I put it on at night before bedtime (the foam). Have zero side effects. Highly recommend this effective product. I can finally wear dark clothing again without fear of white flakes all over my shoulder!"

10 / 10
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  • Luk...
  • Taken for less than 1 month
  • July 22, 2025

For Plaque Psoriasis "I received a sample of the cream from my dermatologist (and then a tube of the foam). On the third day of use, I had diarrhea like I have never experienced before, it was very clearly from taking the medication. I discontinued use. I'd rather have spots than feel sick to my stomach."

5 / 10
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  • Ano...
  • Taken for 1 to 6 months
  • June 28, 2025

"My dermatologist gave me a sample. I had tried at least four other prescription meds to control a persistent bumpy itchy rash on my back. It never completely goes away, but with Zoryve it shrinks and stops itching. I ran out of the samples, so now getting a prescription. It’s the only cream that seems to work."

10 / 10
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  • Anonymous
  • Taken for less than 1 month
  • October 28, 2024

"Just got a sample from the doctor, as the doctor says it is new and pretty unaffordable for most seniors. It's great, went on well, no itching or burning, as my skin on ankles and lower feet is pretty raw and scaly, and long-term, nothing has worked and little to improve my overall condition."

10 / 10
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  • Sik...
  • Taken for less than 1 month
  • November 4, 2024

For Plaque Psoriasis "Started using my Zoryve about a week ago for plaque psoriasis... Behind my ears, it helps with the itching and redness, however, it still has a continuous buildup/flakes. The first of this cream, thought it would get rid of the entire psoriasis... OVERNIGHT."

8 / 10
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  • Ean...
  • Taken for 6 months to 1 year
  • July 11, 2025

For Seborrheic Dermatitis "Fantastic product: easy to apply and very effective with a noticeable improvement in a day or two. Unfortunately, as I’m now on Medicare, the cost (nearly $1000 for one can of foam) makes it impossible to continue."

10 / 10
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  • Arn...
  • Taken for less than 1 month
  • August 15, 2025

"This completely minimized or eliminated my seb derm patches on cheeks, brows, behind ear, and around eyes. I need to get the foam and try it for my scalp, but to have a clear face feels like a miracle. Cream costs $1,119.00 for one 60-gram tube. Way too expensive, but I wanted to start it ASAP, so I just paid it. Government military insurance, so copay card not eligible, but GoodRx knocked the price down to $954.00. Ridiculously expensive, but so far effective. Hopefully, my doctor can get a prior authorization, so then I only need to pay $74. Highly recommend for anyone struggling with seb derm. But they really need to bring down the price!"

9 / 10
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  • KMH...
  • Taken for 1 to 6 months
  • April 10, 2025

"Used Zoryve for persistent (itchy, flaking) dermatitis on scalp (have struggled with this for 25 years). Although it did not completely resolve symptoms, it alleviated them more than other treatments (over-the-counter shampoos, Ketoconazole shampoo, and clobetasol ointment). At the time, it seemed like a modest improvement, but upon returning to my original products, I realize Zoryve, while not able to offer total relief, was far superior to other options. I did not experience any side effects. (I was using some samples provided by my dermatologist. A 5-gram tube was enough to last me a little over a month.)"

8 / 10
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  • Ano...
  • Taken for 1 to 6 months
  • June 26, 2025

For Plaque Psoriasis "Palmoplantar psoriasis - I only apply this cream on hands, heels, and elbows. My insurance covers it (first it was denied, but my doctor insisted, and it was approved). I pay $0. It started working within weeks and greatly improved the miserable condition of cracked heels and fingers. Unfortunately, if I stop and skip days, it returns. The middle of my palms do not heal completely. And it's been months at this point, so I'm not sure Zoryve treats this condition, maybe it just makes it tolerable. Side effects: itchy skin, and I noticed urinary tract related changes like pinkish color of urine sometimes. I don't know what happens if I stop using it - will psoriasis return with a vengeance?"

9 / 10
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  • Cha...
  • Taken for 1 to 6 months
  • August 16, 2025

"I’ve tried everything for 20+ years to treat scalp psoriasis. This really worked at clearing up my scalp. My doctor was actually surprised that this treatment worked so quickly and completely cleared my scalp. I received no compensation for this review. This really worked for me, 57 y male."

10 / 10
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  • gan...
  • Taken for 6 months to 1 year
  • May 6, 2025

For Plaque Psoriasis "Have been dealing with psoriasis for years. Over that time, I've been prescribed several different medications. Zoryve is the first medicine that has actually worked for me. Within 3-4 days of beginning treatment, my plaques were fading and were completely resolved within 2 weeks. Amazing. Other creams I've used were petroleum jelly-based, and I had to wear sacrificial clothing and stay off the good furniture. This is not a problem with the Zoryve. To date, I have not had any noticeable side effects."

10 / 10
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  • Sle...
  • Taken for less than 1 month
  • March 5, 2024

For Plaque Psoriasis "The medication started working immediately but I had insomnia from the first day! Can’t take anymore"

5 / 10
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10 Report
  • Loi...
  • Taken for 1 to 6 months
  • May 30, 2024

For Plaque Psoriasis "Redness and itchiness gone in 2 days. The best medication I have used. I would highly recommend."

10 / 10
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  • Anonymous
  • Taken for less than 1 month
  • June 1, 2024

For Plaque Psoriasis "Stopped itching greatly. Redness disappeared. The only thing that has worked in over three years of treatment. It’s been like a miracle"

10 / 10
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  • drz...
  • Taken for less than 1 month
  • July 17, 2023

For Plaque Psoriasis "Used only for five days. Initial results are dramatic; much better than with calcipotriene/betamethasone and without steroids. See improvement in these five days. Can't speak yet to longer usage."

9 / 10
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  • ecz...
  • Taken for less than 1 month
  • May 10, 2024

"Have used it for about a week on my eczema, and it has helped a lot with that on my neck and face."

6 / 10
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  • jil...
  • Taken for less than 1 month
  • February 28, 2024

"Has worked tremendously when nothing else has worked for treatment of PPP. Almost clear hands and feet in just days. No side effects so far. Zoryve user since January 2024."

9 / 10
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  • Sam...
  • Taken for less than 1 month
  • December 20, 2023

For Plaque Psoriasis "It's a miracle! It changed my life. I am so thankful to whoever invented this."

10 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • December 1, 2024

For Seborrheic Dermatitis "This medication is amazing. 100% symptom relief. Very fast acting and no noticeable side effects. Unfortunately, it is cost prohibitive, and I can no longer afford it."

10 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • September 25, 2024

For Plaque Psoriasis "I have been using Zoryve as a solution to extreme genital itching. It works extremely well for 24 hours. As advised, it does cause mild diarrhea."

9 / 10
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  • Joa...
  • Taken for 1 to 6 months
  • October 19, 2023

For Plaque Psoriasis "So far very good although not 100%, it does relieve the level of itchiness associated with this disease."

8 / 10
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  • Mom...
  • Taken for 1 to 6 months
  • July 20, 2023

For Plaque Psoriasis "It took a while but it is clearing my plaques. I'm very happy with it. I haven't had any negative side effects."

8 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.