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Seroquel XR for Depression User Reviews (Page 2)

Seroquel XR has an average rating of 7.1 out of 10 from a total of 51 reviews for the treatment of Depression. 61% of reviewers reported a positive experience, while 18% reported a negative experience.

Reviews for Seroquel XR

  • Nix
  • January 18, 2012

"I've had depression for 12 years, and have been on Paxil about 10. The Paxil worked for a few years, but the anxiety and depression slowly worked its way back into my life. So along with the Paxil they added other drugs (Effexor, Wellbutrin) but they made me even more anxious. I was finally put on regular Seroquel and found it worked for a little while, but I was so tired all the time I couldn't function the next day. I was literally fired from 3 jobs from being stuck in bed and refusing to get up. I was switched to Seroquel XR 100mg last year combined with the 90mgs of Paxil I'm still on, and I've found a drastic improvement in my mood, anger and anxiety. My only complaint would be how sleepy it makes me in the mornings. A large coffee or a caffeinated beverage does the trick though and its worth the sleepiness to have some peace of mind."

8 / 10
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69 Report
  • Anonymous
  • September 30, 2008

"My 16 year old daughter has been in and out of the hospital for a year and 8 months with alot of ups and downs. She was given Seroquel xr and she is like a new person. She has gained weight from it and wanted to be taken off of it, but as the doctor started taking her off of it she did not like what was happening to her and said I would rather gain weight and be stable then skinny and angry and sad all the time."

10 / 10
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79 Report
  • Indian...
  • Taken for 1 to 2 years
  • September 25, 2013

"I have been on 400mg of Seroquel XR along with my antidepressant for more than 1 year. Initially the medicine worked great for my Stress, Delusions and helped me sleep well in the night. Lately the anxiety has returned and I have severe anxiety during the day time. In the night I pass out so don't feel much in the night. However this medicine has caused me gain a lot of weight. I would say I have gained about 25 pounds since starting the medicine."

8 / 10
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53 Report

Frequently asked questions

  • Emma
  • Taken for 1 to 2 years
  • April 30, 2013

"I was put on 25mg of Seroquel at age 15 due to major depression. I agree with the previous comment made, even on such a low dose I also feel I'm in a chemical straight jacket. I have trouble thinking straight, I can't concentrate for over 15 minutes, my sleep is average - it's extremely hard to wake up. I also find I'm so much more angrier and impulsive, I stutter and can't form words, as well as shaking uncontrollably in my legs when I get anxious. I also get headaches or even at least twice per week. However, my family and close friends have noticed a considerable improvement in my mental health eg suicidal thoughts have almost stopped completely and an increase in more 'happy Emma days'. Such a strong, powerful and dangerous med"

7 / 10
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51 Report
  • Mia
  • Taken for 1 to 6 months
  • September 29, 2018

"I got prescribed Seroquel XR for my sleep and it is supposed to help me with my sleeping and it does. I don’t follow a specific roster of when I’m meant to take it so I’m on and off every week and I only just started noticing that when I start taking it after a while of not taking it my depression gets worse. I’m not really sure of what’s going on."

3 / 10
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29 Report

Are you taking this medicine?

  • sick...
  • Taken for 1 to 6 months
  • August 26, 2015

"Hate this med. Constantly sick on it. Stomach pain, severe diarrhea, passing out, severe dizziness and unable to wake up. Hungry for food all the time. Nasty taste in mouth. Thirsty all the time. Can't motivate myself to do anything. This was on the lowest dose available. Won't take it ever again don't care what my doctor says. No way."

1 / 10
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40 Report
  • Angry...
  • April 11, 2012

"Was taken off Geodon because of night-time anxiety and put on Seroquel XR. I feel so unmotivated. Sedated. I no more feel better by afternoon when it's time to take it again. I dread the next dose. Haven't felt this depressed in a while."

1 / 10
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46 Report
  • Tom...
  • Taken for 2 to 5 years
  • January 29, 2018

"First, I'm not schizophrenic, nor have I been diagnosed as bipolar.. I take this for drug induced anxiety I was initially given Seroquel XR because I exhibited rapid speech & a disorganized thought pattern during my (continual) intoxication by kratom. Kratom is a 'natural', legal substance with opioid and stimulant qualities. Well, I noticed right off that Seroquel XR calmed my racing thoughts. I saw this as a benefit -- but the next move was for me to quit using kratom. I got help for that via SUBOXONE, which I'm still on. My whole life & way of thinking took a sharp turn for the better. I remain on the Seroquel XR, along with the SUBOXONE. When I questioned the continued need for Seroquel XR, my Dr. simply said, "Look, you're doing great. Why change a thing?" And he's right. So Seroquel XR remains a part of my daily recipe for success."

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28 Report
  • AlexisM
  • November 6, 2017

"I've been on this for 4-5 years and it is my rock. It literally helps me so much, I couldn't have made it through high school without it. Honestly it's what helped me through my suicidal phases. I still get them but it's not as intense and I don't try and act on it anymore."

10 / 10
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27 Report
  • Anony...
  • Taken for 1 to 6 months
  • March 30, 2016

"It was mainly prescribed as a sleep aid, in addition to its antidepressant qualities. I was on regular Seroquel and now on XL as I have trouble staying asleep. It's slightly better. I'm getting 6 hours of sleep a night. I am not usually groggy or snowed by this, maybe once per 30 doses. I'm ok with it. Only downside is cost (XL is brand)"

8 / 10
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31 Report
  • Bueler
  • November 7, 2011

"The first night I took this medication, I almost ran out of breath before climbing the stairs from the basement to my room (it's as if my respiratory system was somewhat repressed). It also caused some chest/heart pain. On the other hand, I slept well for those two nights. The side effects may be more dangerous than one's condition. Please be careful."

5 / 10
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39 Report
  • Anonymous
  • April 10, 2009

"I was put on this medicine very aggressively (200mg, quickly upped to 400mg) after a suicide attempt. As an antidepressant it is more effective than the first line medications like citalopram. And will help with sleep and a lack of hunger. However I absolutely hate the side effects. It is often said that antipsychotics "steal your soul" or act like a "mental prison". I would have to agree. To begin with this was fine, with severe depression I was happy to take any way out. However after about 6 months of this I decided enough was enough. Now I'm off it my personality is back."

6 / 10
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44 Report
  • 55 fe...
  • October 17, 2009

"It seems to be very helpful for my depression, anxiety, adult ADD and overall mood. Seroquel XR also seems to have no noticeable side effects and I sleep great. I've been taking 2 of the 300mg, in the evening, now for 2 months."

9 / 10
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41 Report
  • Gastr...
  • Taken for 2 to 5 years
  • May 20, 2017

"I was on this medication for around 3 years at different doses, anywhere from 50 mgs to 600 mgs. It was a very good medicine and helped a lot with my anxiety and depression and really calmed me down and was very helpful, but the weight gain was a killer. I would try to go off over and over and would have to keep going back to it because I would be in such bad shape without it. I had a love/hate relationship with it. I became pre-diabetic while on it. I finally was able to go off and stay off at one point. It's a great drug, but the side effects are horrible as far as weight gain."

8 / 10
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23 Report
  • Dan
  • Taken for 6 months to 1 year
  • July 17, 2021

"I have been on the Seroquel XR 50 mgs and it absolutely works better than anything I have ever taken for anxiety. And I've taken every SSRI under the sun, valium, clonidine, gabapentin, and vistaril all in the past. This medication is a life saver. It does make me feel drowsy 3-4 hours after taking it so it should be taken around dinner time. My doc first started me on it first thing in the morning and I was dozing off by noon. But other than that it has been a lifesaver. Almost no anxiety, I sleep better, my appetite is good, my mood is good & confident. For me it even helps to relax my muscles. I'm so glad my doc took a chance and prescribed this medication off-label for my anxiety. It has given me a new lease on life."

10 / 10
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11 Report
  • Amanda
  • July 23, 2015

"In the beginning I was on 300 mg of seroquel (not extended release) for 3 years. Got pregnant they took me off. I moved provinces they ended up putting me back on a smaller dose 150mg sleeping wise I would go to sleep right away and stay asleep all night. For the past 2 months they decided to put me on 150mg seroquel xl now it takes me hours to fall asleep and I wake up constantly throughout the night and have a hard time falling back asleep! I feel like xl does not work near as good depression wise and sleeping wise."

3 / 10
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23 Report
  • Anonymous
  • September 18, 2011

"Seroquel XR is very good. It boost up my energy. After trying other medications this is the best with little side effects. In the morning you feel like staying in bed and weight gain because of hunger craving. "

9 / 10
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29 Report
  • ssr94...
  • August 18, 2010

"Was put on this medication for mood stabilization as well as for sleep. At the lowest dose it made me excessively drowsy the next day. As for the mood stabilization all it did there was make me have violent outbursts while on the medication."

1 / 10
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22 Report
  • James...
  • January 16, 2021

"This medication Seroquel xr caused me to have body chills, and a hung over fatigue. I couldn't do anything after taking 3 pills it hit me like a ton of bricks. I was totally hung over for 2 day bad headaches and I was shaking non stop. I've stopped this medication can't do it again"

1 / 10
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7 Report
  • Mikey
  • Taken for 1 to 6 months
  • March 9, 2018

"It is ok for me, I can't say it helps that I can notice, I actually do not notice but my doctor says I have improved a lot. I don't get any side effects anymore on 200mg per night, it was ok for staying asleep too as I suffer massively broken sleep, it was no good for getting me to fall asleep. I rate it 5 since I personally see no improvement, but my doctor does."

5 / 10
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10 Report
  • FatMa
  • Taken for 6 months to 1 year
  • May 4, 2022

"I have been on 200 mg of Seroquel XR for about 7 months. I am underweight and it did not cause me weight gain. It has been working miracles for my mental health, but I just started tapering because the side effects are sometimes excruciating. After half an hour of taking the med I can’t walk or talk. I can hardly breathe and the RLS is terrible sometimes. But those side effects only last 2 hours after taking the med. I am also stopping it because I have been feeling great and I don’t think I need it anymore. (I’ve depression with psychotic features and used to frequently experience depersonalization + derealization and some delusional thoughts + disorganized thinking). All which decreased in intensity rapidly after starting Seroquel. Generally, it was a good experience for the most part. It really helped with my memory and information processing."

8 / 10
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2 Report
  • No Th...
  • Taken for 1 to 6 months
  • December 1, 2021

"On this for Depression & Bi-Polar. Terrible word blockage. Would experience electrical like zaps in my brain. Felt like a zombie, unable to focus, no energy to do anything. Slept for 16+ hours every single time I took it."

1 / 10
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2 Report
  • Whats...
  • March 22, 2010

"It helps. Will make you feel better about yourself."

10 / 10
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48 Report
  • Nissan...
  • Taken for 10 years or more
  • October 26, 2019

"All is does for me is help me sleep. I'm addicted to it now..!! Can't sleep without it.. And it cost $100.00 a month!!! I wouldn't recommend me to anyone...!!!"

7 / 10
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19 Report
  • angela...
  • December 16, 2012

"Quetiapine 25mg used to get over Post traumatic stress disorder post Mental Health problems caused by an allergy to Valium. Presently taking 50% of a tablet at night."

10 / 10
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32 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.