Naloxegol for Constipation, Drug Induced User Reviews (Page 3)

• Ell...
• Taken for 6 months to 1 year
• August 13, 2016

"Used opioids for years, went on methadone and Movantik, and worked within hours after not going for a week at a time, almost regularly. Now go every day and have lost 10 pounds to boot! So happy this drug exists. I had no pain at first, a little intestinal cramping moving out of my system. After a few days, regular, no cramping at all, miracle fix for constipation for people who have to regularly take pain meds!"

• Cho...
• September 22, 2015

"9-17-2015 The other reviews compel me to expand my comments. All Movantik does is land on the receptors in your stomach. These receptors are the ones opioids normally land on, which makes it difficult to have a movement. I still have responsibility for what I eat and for taking stool softeners and Senna tablets, so my stool is soft. Otherwise, I would be experiencing possible blockages. It has now been 3 weeks, and it works for me. But you have to pay attention. Also, I am not a doctor. This is just my experience."

• RSD...
• Taken for less than 1 month
• November 8, 2016

"I have full body RSD (CRPS). I started taking opiates for the first time, 10 mg of Methadone 2x a day since October of 2015. Linzess high dose never really worked. I tried Movantik, and it worked the first day. After that, horrific abdominal pain and cramping. Almost couldn't drive when it hit me when I went to vote here in Florida. This drug is garbage. Expensive garbage. Try it, but be careful. Don't get your hopes up."

• Hro...
• January 2, 2016

"I started using Movantik for the first time on New Year's Day. I read all I could about the drug and decided to take it. After about 15-20 minutes, I experienced some very minor abdominal discomfort. After about another 15 minutes, I had the feeling I had to make a bowel movement. I was amazed the medication worked so well and quickly. I had my bowel movement. I had to make another smaller bowel movement hours later that same day. So far, the first day of using this medication was a success."

• Max...
• Taken for less than 1 month
• November 29, 2015

"This drug has been amazing for me over the past week that I've been taking it. My experience does not match the other reviews here in any way. I take Movantik in the early morning, and a few hours later I have a bowel movement - a normal bowel movement, not diarrhea. It's been very good for me."

• Jes...
• August 27, 2016

"This medication literally saved my husband's life. He has been on OxyContin for 16 years. He's tried everything! He truly thought he'd have a heart attack from pushing. The doctor gave him samples of Movantik, and 30 minutes later, a BM. No problem. Been the same story for over a month. I saw so many negative reviews, and I'm so sorry this didn't work for you... I hope you find the one thing that does!"

• Gre...
• Taken for less than 1 month
• July 8, 2017

"My pain management doc has me on time-release morphine for spinal injuries because other modalities have not worked. Of course, I have severe constipation. Was given samples of Movantik. I took one pill and within one half hour, had severe cramping, and within one hour, total diarrhea. Also had some withdrawal symptoms. I waited a few days, became constipated again, and thought I would try it again. Same effect again except this time, I am three days out from taking the Movantik, and I am still experiencing withdrawal symptoms... nervousness, runny nose, anxiety, headache, and nausea. I have reported the adverse reactions to my doc and will be reporting them to the FDA as well. I am a 67-year-old male."

• Pea...
• Taken for less than 1 month
• June 13, 2015

"Well, it did what this medicine was supposed to do, although it did cause a small duodenum perforation that landed me in the hospital. I had severe constipation from methadone, which I came off of due to this issue. I felt no pain, I'd like to add, and I would give it the thumbs up. Umm, I was prescribed it after my second day off methadone to reverse the problem. It seemed to work. Better, gentler than Relistor. Hopefully, you folks find this helpful. Also, I did have a little withdrawal, such as sneezing and mild bone chills, but the end outcome I feel was well worth it!! Good luck!"

• Ell...
• April 24, 2016

"I've been in pain management for 6 years, and serious constipation started 2 years ago. Linzess and Amitiza did not work. I was stuck using enemas and self-manual removal. Awful - and takes time. I have drank 3 Magnesium Citrates with no BM! Movantik works, but insurance won't pay, so I take 1/week from the few samples I get. The pain that starts within an hour of Movantik is the worst I've experienced: doubled over at the gut, crying like it could be an ER problem. But I am doubtful of ERs, so I try to make myself comfortable at home while I empty for 5-24 hours. Bloated, completely uncomfortable, and must plan to do nothing until the BMs end. Do feel a little withdrawal, so I take meds. Movantik is my only option. Wish it was more gentle."

• Wea...
• Taken for 1 to 6 months
• July 3, 2018

"I’ve been on opioids for about 10 years and have always had problems going to the bathroom (constipation). My doctor gave me 25 mg Movantik to take in the morning, and it worked for me within an hour of taking it. It gave me horrible cramps, so we’ve cut the dose to 12.5 mg. I still cramp a little, but that’s my only side effect. Some days I don’t go to the bathroom after taking Movantik, but sometimes I don’t eat much due to pain. I will never go without Movantik. I feel so much better every day not being bloated and ‘backed up.’"

• Kri...
• Taken for 1 to 6 months
• October 29, 2015

"I have had a very positive experience with this drug daily over the last 2 months. Side effects, nil. If you are concerned about side effects, you should talk to your physician, but my two cents would be not to be dissuaded by a few bad experiences reported on this board, as those are extreme outliers if you look at the label. Anyway, the best advice is always to talk to your doc. Good luck if you are looking for help on OTC drugs, like I was!"

• Com...
• July 18, 2016

"I have been on opioids for over 10 years and have always had a problem with constipation. I have used several over-the-counter stool softeners, which rarely worked. I could sometimes go almost a week before having a bowel movement. I continue to live with this issue until my doctor recommended Movantik. He provided me with samples, which I started immediately. This drug is a miracle! I have had a bowel movement almost every day. I have not had any side effects, and I feel great."

• Hig...
• Taken for 1 to 6 months
• September 28, 2018

"I have been on opioids for over 8 years. Movantik was suggested after an ER visit due to constipation. On my first night of taking this pill, I went into the ER with severe diarrhea (5 episodes in 2 hours), cramping, and nausea. I took the pill again the next night and still got cramps with diarrhea, but both were not as bad as the night before. I kept taking the pill at night before bed, and the side effects got better and better with each continuous night. By the second week, I was no longer cramping nor getting diarrhea. When taken at 10 pm, I would have a bowel movement at about 6 am, and it was loose without needing a laxative. It is my suggestion that even if the first few nights bring diarrhea, cramping, nausea, and other discomforts, to stick with it; it will get better. As painful as those first few nights may be, the long-term outcome of it will be worth it more than the struggle of dealing with the consequences of not staying on Movantik."

• Swn...
• Taken for less than 1 month
• May 25, 2016

"I have been on different opioids for a chronic pain issue for 15 years, but since I started taking methadone 5 years ago, I've had horrible problems with constipation. They kept me on Miralax 34 mg twice a day and stool softeners, but even that would only allow me to use the bathroom maybe 3 times a week. I was given Relistor as the injection at home, and the pain was unbearable for 9 hours, and it did not work. I was so scared to take Movantik, but I'm so glad that I did! Just one pill and everything inside me finally came out! My cramping is very minimal, nothing that really hurts much at all, more 'Hey, the pill is working' type of movement and cramps. They have coupons for $20!"

• jnl...
• Taken for less than 1 month
• August 3, 2018

"I've been on opioids for severe neck and back pain (post-surgical) for more than 10 years. My gastro tested me on several drugs for constipation without success. Movantik was the least expensive and actually created a serious BM within an hour. Unfortunately, I experienced severe cramping, sweating, lightheadedness, and exhaustion during and 1 hour after. I won't take Movantik every day due to cramping, sweating, and weakness, but I can endure the pain once a week. In all fairness, I started Oxygenated Magnesium 07 (magnesium oxide) from a health shop - 3 at night. Mag 07 gave me one BM every 3 days. If I take 4 Mag 07 at night, I have a decent BM the next day. Nowhere near as significant as Movantik, but NO cramping, sweats, etc. Mag 07 may well have set the stage for success with Movantik. I'll stay with Mag 07 and Movantik only once a week. For me, this is a magic combination."

• Coc...
• Taken for less than 1 month
• May 2, 2016

"I was surprised when I read all the comments about the side effects. I should have read this site before I took Movantik. I also thought I was going to die, I had all the side effects listed here. I'm afraid to take it again. I'll try cutting the pill to a quarter and see if it works without the side effects. I will keep you posted."

• joh...
• Taken for 1 to 6 months
• October 25, 2015

"Tried OTC, and nothing worked. This worked quickly for me and has now continued to work for 5 weeks. Have read this board re side effects of others, but that has not been my experience. Read the label and talk to your doc -- looks like overall the experience of bad side effects is rare for patients who try this med, but talk about it with your doc -- for me, this has worked where nothing else did."

• No...
• Taken for less than 1 month
• August 26, 2016

"My advice on Movantik is to understand that Movantik is an opioid blocker in the same manner that naloxone (found in Suboxone) is an opioid blocker. My husband took 12.5 mg and was thrown into withdrawal. Nausea first, chills, fever, shaking so hard the bed was vibrating. I thought Movantik worked on the backed-up s**t, but it stops the opioid from working. Of course, you will have diarrhea when your pain meds are cut off. It may not happen to everyone, but it happened to my husband. I guess it's back to OIC."

• Knu...
• April 3, 2016

"Before being put on Movantik, I was only having a bowel movement some times 3 days, some times 5 or even hit 10 days once. Then I finally was put on Movantik, and now I'm going every 2 days, and at least I'm not in pain when I go to the restroom."

• Opi...
• Taken for less than 1 month
• February 17, 2016

"I've been on opiates for many years because of lumbar scoliosis with multiple failed back surgeries. As of the last 5 or 6 months, my constipation worsened to the point where no laxatives were effective. My bowels had almost stopped working. So far, after 3 weeks on Movantik, I have a regular BM almost every day. I do have to use a little Milk of Mag and a stool softener and eat oatmeal to help it along, but I am so much better! I am grateful for this drug, but it is very expensive. I had to make a choice on whether to stay unclogged or take a camping trip to Big Sur. I chose to be unclogged. Sad, I know, but health comes first. Hopefully, I will get an authorization soon. I am not impressed with Obamacare."

• lov...
• Taken for less than 1 month
• December 19, 2016

"This is crazy. Today is my 4th day in a row to take Movantik, and no effects. On the first day, I went to the bathroom, and nothing since. No pain, no poop, no nothing! Weird, huh? But I will tell you after I had taken my first dose, I started doing some reading on the med, and OMGOSH, I read some horror stories, so immediately I prayed that the med would have no bad effect on me, and it has not had one single pain or bad effect on me, and it's the fourth day, so I think all is good. And although I've only pooped one time, my bloating has subsided greatly. Ooooh, and bloating was a HUGE issue for me. I will update in a week or so."

• Swa...
• December 8, 2016

"Movantik worked like a charm for me - when used correctly, meaning no sooner than 2 hours after your last meal or 1 hour before your first meal of the day. I suffer from pain due to nerve damage in the lower back (S1 nerve root) after multiple surgeries and take oxy and Percocet daily. When I did not follow that very simple schedule (by accident), i.e., took it too close to my last meal, I had horrible bloating, pain, cramping, and terrible diarrhea. So I would guess that many of the negative reviews on here may be because of misuse."

• Bil...
• February 17, 2016

"Ditto on every negative review I've read about this drug. I have had severe hemorrhoid swelling, burning, and pain caused by the pressure of OIC. Although this drug was effective, the nightmare which preceded relief far outweighs ever taking this Big Pharma disaster. A mule couldn't tolerate this drug."

• Kiv...
• March 20, 2016

"Taking it for three months and no bowel movements. I have one movement a month. I really need to poop. All this medicine does is make me feel sick. I take it as it says and nothing happens. In between, I take Miralax, still nothing. I get nauseous, vomiting a lot of the time. Cramps, I am so tired of being full of bowel."

• dav...
• September 7, 2016

"Omg, this was by far the worst medication ever. Sick is an understatement, throwing up, out of both ends, cold sweats, like going through withdrawal. Be careful if you try this. You're going to be sick."