Naloxegol for Constipation, Drug Induced User Reviews (Page 2)

• Jen...
• Taken for less than 1 month
• November 3, 2016

"OMG! This is horrible! The cramps and bloating are the worst I've ever had! I suffer from multiple pain issues, fibromyalgia, severe neck and back pain with shooting pins and needles with burning down my legs, due to a failed back surgery. I'll take that pain over the pain I have from Movantik. I have been back and forth from the bathroom and sat on the pot till both of my legs are numb. Nothing's moving, but I'm having such bad cramps I can't move."

• Cak...
• Taken for less than 1 month
• October 17, 2015

"I have chronic pain issues and have for years. I am on OxyContin & oxycodone. I have dealt with drug-induced constipation for years. I will NOT ever take another dose of this medicine. It's been several hours since I took my first dose, and I was surprised that I had a bowel movement within an hour. Regular, which was nice for once, then had to go again right away... and again... and again, and things got softer, then went to liquid. I went to bed around 1 am and was awoken with an urgency to go to the bathroom, only to find that I had 'wet' the bed by the bowel leaking while I slept for ONE hour. My bed was soaked, I was soaked. Not only was I humiliated like a child would be, but the diarrhea isn't stopping! From what I read, the best is yet to come!!"

• Vly...
• Taken for less than 1 month
• September 5, 2015

"3 stars because it induced a BM. I had been constipated for a couple of weeks, not no BMs but few and incomplete, with bloating and discomfort. From reading the literature, I thought this might work after several hours. But, wham! One hour after taking (on an empty stomach to decrease systemic uptake), I had a large BM. Great, but then I got severe intestinal cramps. Thought I was going to perforate something. After a couple of hours, then watery explosive diarrhea the rest of the day. OK, it cleaned me out, but at the expense of great pain and inconvenience. I'll go back to Senna & Miralax. Perhaps my opioid intake is too high for this? It was tested on people taking morphine equivalents between 30 and 100 mg/day. I take more than that."

• Mar...
• Taken for less than 1 month
• October 2, 2016

"Awful stomach pain that lasted hours. Very small amount of diarrhea. Not worth the pain. I threw the medication away, it was that bad. I didn't want to be tempted to take it again. It's really that bad. I wouldn't even bother halving the 25 mg tablet. Also, the fact that it seems to suck the options out of your body. I'm in more pain than before. Unfortunately, I had taken my morphine before this drug. Stay away from it, terrible medication."

• Jum...
• December 15, 2016

"I've been taking opioids for back pain for almost a year, so I've been dealing with constipation for about the same length of time. I took Movantik last night for the first time, and within an hour I had a racing heart, shortness of breath, and a throbbing headache. Now, 20 hours later, I'm so irritable I could spit and can hardly think straight. 24 hours of anxiety, cramps, and nausea! I'm so grateful to see these reviews because I don't feel alone and crazy."

• Ran...
• Taken for less than 1 month
• August 23, 2015

"I have had constipation for months since taking pain meds that I need for extreme back pain. The constipation has been so bad that it has made my back pain even worse. My doc gave me Movantik, and it has truly saved my life. It has regulated me and made me regular again with hardly any straining. I cannot say enough good things about Movantik and how it's been a game changer for me. Amazing!"

• Int...
• November 26, 2015

"I have read all of the reviews and am surprised at so many with serious side effects. That is a shame because I have had remarkable success with Movantik. I have taken opioids for 8 years due to chronic and severe degenerative disk disease. I have taken fentanyl, morphine, oxycontin, hydromorphone, etc. The most current treatment is 24 mg of hydromorphone and 15 mg of methadone per day. Constipation was a terrible side effect. I continually used OTC of all types, to little avail. At times, I would go 4-6 days w/o a BM. I had a BM on the first day I took 25 mg of Movantik. No side effects. I take it once per day and have a BM almost once per day. Sometime at the most every two days. Stools are not irregular. For me, a miracle drug."

• THI...
• Taken for less than 1 month
• August 24, 2016

"I have taken opiates for many years primarily for back pain. I have OIC and tried numerous over-the-counter meds. For whatever reason, the OTC laxatives, stool softeners, and even Miralax caused a horrible interaction with my methadone, and I felt like I was poisoned until I stopped taking the OTC meds for about 5 days. Anyway... my Dr. recommended Movantik. I took the first 25 mg pill, and in about 2 hours, I had a successful, somewhat easy bowel movement. About 15 minutes later, what felt like 5 pounds of excrement came out. The first week was great. Here is where it gets awful... It wasn't until almost 2 full weeks into taking Movantik that I began having HORRIBLE methadone withdrawal symptoms. I quit taking Movantik. NEVER AGAIN!!!"

• MB0...
• Taken for less than 1 month
• December 24, 2015

"I lasted less than 3 weeks on Movantik my provider recommended! I ended up at the ER because of the severe cramping, violent vomiting, bloating, nausea that had occurred. I'm being asked if I had ever had colitis or diverticulitis in the past, which is a fat no! They had to put me on an IV because of the dehydration. I've been off Movantik for a while, and my GI is still irritated. Huge disappointment, but I'd rather give natural birth to more children because it was a breeze compared to the experience I had with Movantik! Now it appears I have to seek a GI doc to deal with the aftereffects of being on it!"

• Lex...
• Taken for 1 to 6 months
• August 17, 2015

"Movantik works. It's somewhat inconsistent. Most days I can count on it. On an occasional day, things don't move as well. On those days, I supplement with a Dulcolax suppository. Be advised that it may take 2-3 days for your system to get used to it. I felt a little tired and edgy. I think that's because it may induce some opiate withdrawal effects. It was only temporary and tolerable. These are all minor issues. Like I said, it works, and that's a big relief for an opiate user."

• enw...
• October 3, 2016

"Talk about induced anxiety! I have never felt so absolutely horrific as I did when using this medication. My doctor prescribed it one week after shoulder surgery when I was having severe stomach problems and constipation. I had already stopped taking Percocet when I started taking it. And when I still wasn't pooping...you guessed it, the doctor prescribed additional dosage! I was crying, in a state of panic, unable to sleep---I never ever want to feel this way again. After reading up on it, you are not supposed to take Movantik if you are not taking opioids! Thank you for the medically induced anxiety horror show."

• Gam...
• Taken for 1 to 6 months
• October 12, 2015

"I used samples of Relistor first. Although it caused massive abdominal pain for 30 minutes to an hour, it worked. Unfortunately, it costs $2,000 a month, and my insurance won't cover it. On to Movantik. Side effects are horrible. Major withdrawal symptoms. Severe sweating, shaking, going from extremely hot to teeth-chattering cold, yawning 50 times in a row, heart palpitations, massive abdominal pain, skin feels like it's crawling with sharp objects for hours. When I say hours, I mean 12-15 hours after my dose. Which was dropped from 25 mg to 12.5 mg. I have a bowel movement after taking about 20% of the time. I don't have a lot of choices though. In 2012, my colon ripped in half. I was in critical care, trying to not go through that hell again."

• BAD...
• Taken for 6 months to 1 year
• January 20, 2017

"I tried Movantik, and it worked very quickly but made my stool pure blood. I had heard about that side effect before but never experienced it until then. It scared the hell out of me. I haven't taken it since."

• Hop...
• October 31, 2015

"I get violently sick. I vomit, migraine, stomach cramps, and lingering headache after a 24-hour period. But I am so desperate sometimes I put myself through it to feel better for a couple of days after. I can't take it every day or I would never be able to leave home because of side effects."

• Mtr...
• March 14, 2016

"I have to say I was somewhat relieved to see that I wasn't the only one who suffered so greatly with this drug. The experience (but sad to see others suffering). I truly thought I was dying, and I kept telling myself it'll be over soon, it'll be over soon. The pain, chills, and vomiting, absolute suffering, were unlike anything in recent memory for me. I'll never take this drug again, and I'm afraid to take anything like it, it was that severe of a reaction, and this was my 4th day taking this drug. The first night, the cramps were pretty rough but short-lived. Last night, I just truly never thought I was going to survive it. It lasted about 3 hours, which felt like an eternity. Today I'm just so weak feeling. It's going in the garbage. $323 wasted."

• Joy...
• Taken for 1 to 6 months
• October 23, 2018

"My doctor had me try Movantik because I have had 4 back surgeries, all failed to relieve the pain, so now I have to take pain meds just to feel halfway human. I took the Movantik, and it worked really fast the first few times I took it and is still working, not as fast, but it works. Yes, you can get cramps and shouldn't plan on doing much after taking it because you never know when it's going to kick in. I can handle the side effects, and they can be painful. I am so glad that they finally got something that does what it says it's going to do. If you're uncomfortable because you're backed up, give it a try. Good luck to everyone that gives it a try."

• Tre...
• Taken for 1 to 6 months
• November 16, 2018

"My opioid constipation condition was really awful because my Dr. had not suggested a laxative at the time of writing prescriptions for hydrocodone, later oxycodone and Percocet, and I had been taking all of these for more than 2 months and had recently not had a bowel movement in 6 days. I was miserable and couldn't even sit up straight. Movantik was the 3rd prescribed laxative I tried, as the other 2 didn't work consistently. I am very grateful for Movantik. I take it on an empty stomach, first thing in the morning, very little cramping to speak of and (for me) within 2 to 4 hours, I have relief. If I miss a day, I notice I'm not able to go, but I simply make sure to take it every morning for every day I'm taking opioids. I have definitely found that Movantik works for me."

• SPI...
• Taken for 1 to 6 months
• July 28, 2015

"As a follow-up to my previous post: after taking for approximately 6 weeks, I have the following side effects to report. Marked drowsiness for the first few weeks, now gone. Increased facial sweating, excessive sweat only from my face despite not being warm, though it is not always a daily occurrence, it still continues. Lastly, I do very occasionally experience yawning an hour or so after taking my morning dose, usually after a sizable bowel movement. Overall, this drug has GREATLY IMPROVED my quality of life, VERY effective with virtually no side effects. I do need to take a Bisacodyl laxative based on what I eat, but I HIGHLY recommend you try this if on long-term opiates like me!!"

• RNS...
• July 22, 2015

"My PM MD gave me samples after being constantly constipated for 2 years. Post L5-S1 disc replacement - 50 mcg/hr q72h of fentanyl and 10 mg oxycodone 6x day. The 1st time you take Movantik, make sure you take it on a day off from work! I took it on a weekend, first thing in the AM as the instructions say (1 hr before your 1st meal) and had a BM approximately 4 hrs later. I strongly suggest taking a stool softener - the BM was so wide from sitting in my intestines that I cut myself while going and bled (awful feeling). I tried taking every other day but it gave me nausea the day of taking it and usually the day after, very painful cramping before, during, and after taking the pill and having a BM, and decreased appetite. Will try Relistor inj next."

• Bub...
• Taken for less than 1 month
• November 22, 2016

"Been on opioids for a few years. Taking Miralax for constipation. Dr. asked this month how my constipation was going. When I mentioned going twice a week, she seemed to think that wasn't good, so gave me samples of Movantik 25 mg. Took it for the first time before dinner, and it worked great! Thought I would just take it when feeling constipation. A few days later, took a morning dose. I used the bathroom fine, but afterwards, oh the pain! The worst stabbing lower intestine pain I've ever felt. It came in waves for hours. Bent over thinking of going to the ER. I've been impacted before and had to go to the ER. So embarrassing, but would choose that over Movantik every time!"

• D-M...
• Taken for less than 1 month
• September 3, 2016

"I have been on 100 mg of methadone for almost 4 months, and my constipation has been miserable! It got to the point where I was so bloated that my pants were not fitting, and I had to buy new ones because of all the stool in my stomach. Well, I got desperate and asked my doctor for help, and after being prescribed lesser stimulant laxatives and Colace to no avail, I landed on Movantik. I took it after I ate dinner (2 hours after, as instructed), and I ended up going to bed only with a slight cramp in my stomach. I am positive it was not due to the med, it felt as if my intestines were waking up and beginning to work again. When I woke, I had the best, most normal BM ever. I am so happy with this med, 12/10. I will update if anything changes. 9/3/16"

• Dia...
• Taken for less than 1 month
• September 22, 2016

"I have been on a small amount of Methadone, 5 mg twice daily. I can only go to the bathroom like 1 - 2 times a week, and then it's little hard balls. I took Movantik, 25 mg 1 time and went within 1 hour. That would have been okay, but then a few minutes later my stomach hurt, I mean really hurt. I was in tears. Then I went again. Well, I have gone so much it is pure water now, and I will not take this again. I would be scared to try the 12.5 mg. No withdrawal symptoms, but the runs. Well, the last time I had this that bad my kidneys were shutting down, so I fear for this. Cannot eat or drink anything, it runs right through me... Be careful, I would try the lower amount first and see how that goes."

• Jen...
• August 6, 2018

"My doctor gave me this because I’m on high doses of opioids for Complex Regional Pain Syndrome (CRPS) or Reflex Sympathetic Dystrophy (RSD) and spinal arachnoiditis. This was horrible. I was given trial packs first. 25 mg I took, then so much pain in my belly I could not move. I was curled in the fetal position contemplating calling an ambulance. Horrific pain and deep bone pain in both my legs, far worse than my CRPS pain, plus nauseous, chills, I thought I was dying. Horrible. Threw them in the trash."

• Jax...
• Taken for less than 1 month
• February 13, 2016

"Worst reaction to a drug I ever had. Horrible 24 hrs after taking the first 25 mg sample. Severe stomach ache, bloating, and cramping. Severe, extreme dizziness...and the drug blocked my morphine and gave me horrible opioid withdrawal effects. I was close to going to the ER but kept telling myself it would be over soon. It didn't happen for 30 hrs. Felt like passing out...I was a mess. I take a lot of meds for chronic Lyme, fibro, and chronic CRPS pain. I would never take this again. What has helped me is the OTC diet pill ALLI, which blocks fat from absorbing in the stomach, and Linzess. The Movantik was a horrible experience for me and will never take again...opioid withdrawal symptoms are awful."

• Riv...
• Taken for 1 to 2 years
• February 24, 2019

"I've tried every laxative (OTC and prescription) for my Suboxone-induced constipation, and while it does cause withdrawal and some pain, it actually works without me needing to stay home all day so I can be near a toilet. I will say that it seems to weaken the effects of the Suboxone."