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Levomilnacipran User Reviews & Ratings (Page 3)

Brand names: Fetzima

Levomilnacipran has an average rating of 5.1 out of 10 from a total of 211 reviews on Drugs.com. 37% of reviewers reported a positive experience, while 44% reported a negative experience.

Reviews for Levomilnacipran

  • Sophi...
  • Taken for 1 to 2 years
  • July 5, 2017

Fetzima (levomilnacipran) for Major Depressive Disorder "I've tried 20+ meds over the last 30 years to treat depression. I've had wonderful results with Fetzima and Trileptal. I've been on the medication about 18 months now. Some GI issues, some sweating, though not as intense as others have mentioned. As I've increased dosage I definitely experienced rage, but it subsided within a week. I've had an increase in blood pressure, but it was already high & a med adjustment solved it. A weird side effect: I talk a lot more than I did before. I can stop myself, but the tendency is new. I can deal with these side effects. They've not been intense or long lasting. My depression was horrible for 7+ years. I've gone from failed suicide attempts to feeling good again. I'm very grateful for this drug."

9 / 10
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  • 916
  • Taken for 2 to 5 years
  • August 27, 2017

Fetzima (levomilnacipran) for Major Depressive Disorder "Fetzima, I was originally turned off by the name because of the douchey Zima drink that was the rage for a few months back in 2009. After that I have to say this medication works FOR ME. Everyone is different. I've tried almost everything in a psych. Hand book even cocktails of medications. I am happy to say the current 80 mg dose has been a dramatic change in my life. Like most with bad depression and anxiety stemming from childhood it can be crippling effecting everything an everyone in your life. I'm happy to say I have turned things around on this particular cocktail of medication but I will say this the fetzima is the thing that made the difference. It's like adding mint to a mojito. Things turnedgood from the start of fetzima."

10 / 10
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  • Somet...
  • Taken for 1 to 6 months
  • August 21, 2015

Fetzima (levomilnacipran) for Major Depressive Disorder "I've been on Fetzima 3 months. I take the 40 MG extended release. This has been the best medication I have been on. I have increased energy. I can focus and stay on task. I do not feel hopeless and have an opinion now. The side effects I have are dry mouth, constipation, my face and chest will turn red and feel hot to me at times, my neck will break out. I have also had some irritability and anger. I feel like this is because I walked around is a fog with no thoughts or opinions for so long that now I'm engaged in life and paying attention somethings that use to not bother me do now. For me my effects from this medication have not changed at all. The benefits definitely outweigh the mild side effects."

8 / 10
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Frequently asked questions

  • Ballo...
  • Taken for 1 to 6 months
  • November 2, 2020

Fetzima (levomilnacipran) for Depression "I’ve added Fetzima to my maximum dose of Wellbutrin (which I have no negative effects from and been on for years) and it became clear to me a week in that there is a large change in mood for me. It takes some getting used to for sure ... my dreams are vivid but not unpleasant. I’m definitely more focused, less anxious, and have nice happy almost euphoric parts of the day. I’m very sexual? Which was unexpected but I’ll take it lol. So the top strange effect right now are isolated goosebumps, heightened sexual drive, vivid dreams and occasionally flushing for me. From the reviews it really seems like a love-it or hate-it med, and you know quickly what you think of it. I love it and it’s a 50/50 shot so worth a try!"

9 / 10
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  • Tina...
  • January 19, 2016

Fetzima (levomilnacipran) for Depression "I tried 40 mg of this medication for about 8 weeks. Initially (1st 2 weeks) it seemed to work. Then, for the last 6 weeks, it seemed not to work. I had side effects of tummy pain, leg cramps and irritability. My doctor insisted I was getting better and just needed a higher dose. So she put me on 80 mg of this medication. I began to experience extreme bursts of anger and negativity, which of course only worsened the depression. I also had horrid stomach pain and couldn't tolerate it. After going off the medicine, I felt much better. No expense, no leg cramps, heart rate down, rage bursts abruptly stopped after about a week. Yay, I guess. Back to Amitriptyline..."

2 / 10
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Are you taking this medicine?

  • xannx...
  • October 27, 2015

Fetzima (levomilnacipran) for Depression "I was on fetzima for about 8 months ending at 100 mg. I now have severe dry eyes with possible glaucoma. This medicine make me very manic with severe dry mouth, eyes and dry skin. I thought is was my sinuses that gave me the terrible pain in my eyes so after waiting to see a specialist ENT and eye Dr. I am stuck with lose of vision . I have been on antidepressents for years and have never had a problem like this. I Have been off fetzima for 2 months a still suffering the side effects."

1 / 10
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  • 6xxxx...
  • Taken for 1 to 2 years
  • February 8, 2017

Fetzima (levomilnacipran) for Major Depressive Disorder "I have been on Fetzima for around 18 months, and this is truly a miracle drug. I have MDD, PTSD, GAD, and BED. I come from a family based in the medical field, and as such I have tried every drug on the books. Almost two years ago, my anxiety got so bad that every night I felt like I was going to suffocate and die in my sleep. I was having multiple daily panic attacks. I was started on 40 mg of Fetzima, and before the week was out my panic attacks had all but ceased. I'm now on 80 mg. I can't remember the last time I had one as bad as the panic attacks I was having before I started Fetzima. I gave it a 9/10 because I'm still sweating as a side effect. I also take Vyvanse, and Propranolol and Abilify as needed."

9 / 10
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  • In...
  • April 4, 2019

Fetzima (levomilnacipran) for Major Depressive Disorder "I have been on meds throughout the years since I was around 18. I finally gave in and tried meds. Needless to say, it hasn't been successful. I've never had a positive experience. They work for some time and then quit, or don't work at all. My latest med provider had me take the genetic test to see what medications would metabolize correctly. Fetzima was listed as one of them. Needless to say, it has worked wonders. While I still have depression, and one anti-depressant isn't enough, this one hasn't given me a lot of side effects that others have. I am on another one as a mood booster. Because of the known irritation side effect, my provider had me take the initial dosing for roughly a week before titrating up to 40 mg. I am now on 80 mg and doing well. I am glad I asked for this medication. I have gotten energy back and not always wanting to be sleeping, not motivated or other issues I faced when I'm not on a medication that works."

10 / 10
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  • Meep
  • June 28, 2020

Fetzima (levomilnacipran) for Major Depressive Disorder "I have MDD, GAD, residual PTSD symptoms & nerve damage that causes pain and loads of other issues. I started this in Feb-March 2019 after 2 other failed antidepressants, adverse reactions. I've had 2 med increases over the last year and currently just started the 2nd to get me up to max dosage (similar drugs have been used to treat chronic pain, so that's the theory my doc is going off of). It has been a life saver in conjunction with Buspar for my anxiety. It got rid of most of the urges that came with sucidual idealization and self harm urges during the hardest time of my life(becoming disabled because of the nerve damage). It has helped with my energy levels (mdd+chronic pain=extreme fatigue) and has helped make therapy more effective for me. The side effects I've experienced is the increase in sweating, lower salt in my body, which makes it harder to stay hydrated and nausea when starting it & at med increases but it goes away within about a week."

9 / 10
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  • i m P...
  • Taken for less than 1 month
  • May 23, 2015

Fetzima (levomilnacipran) for Major Depressive Disorder "Other meds not effective and troubling to Doctor. I started FETZIMA 40mg 5 days ago, including taper off Wellbutron and Escaltalipram. Side effects - heavy sweating, couple of headaches, occasional nausea, frequent diarrhea, little bouts of grouchy, inconsistent sleep, feel unsteady - - improved mood, better energy. I'm hoping for negative effects to stop or be manageable. I see Dr in a week. I'll hang in there til then ."

5 / 10
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  • I...
  • Taken for 1 to 6 months
  • October 16, 2015

Fetzima (levomilnacipran) for Major Depressive Disorder "I am going to try a different A/D as this is NOT working out. I started out taking 80 mg of Fetzima 3 months ago, & the doctor lowered my dose to 40 mg about 6 weeks ago because of anxiety. Fetzima has worked for my depression but my anxiety is through the roof! I also sweat like a pig & that causes my electrolytes to flush out, then I start getting severe body cramps. One moment I feel hot as can be, then the next I am cold as ice. I have "never" had side effects like this on any other A/D, and I am done with this!!"

4 / 10
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  • bamakc
  • Taken for less than 1 month
  • September 8, 2015

Fetzima (levomilnacipran) for Depression "I was switched from celexa to fetzima. I started on 20mg for a few days then increased to 40mg. It did not helped my depression at all. I was crying and repetitive thoughts. Side effects were awful: constipation, dizziness, retrograde ejaculation, anxiety, irritability etc...I switched to viibyrd. So far its a lot better."

2 / 10
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  • JT263
  • Taken for less than 1 month
  • March 24, 2015

Fetzima (levomilnacipran) for Major Depressive Disorder "This medicine can be very dangerous and send you into Serotonin Syndrome. I ask everyone out there to please know the symptoms of Serotonin Syndrome and report to you nearest Emergency Room Immediately if you are having symptoms."

1 / 10
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  • 8...
  • Taken for 6 months to 1 year
  • December 2, 2016

Fetzima (levomilnacipran) for Major Depressive Disorder "For last 8 months, Fetzima has worked very well (after the initial transition period from my last medication.) Over the last 15 years, I have been on many effective anti-depressants, but after about 2-3 years these medications start to become ineffective (Zoloft, Lexapro, Cymbalta, etc). Started taking Fetzima 8 months ago, and the first month involved a lot of agitation/anger (very unlike me) and also having to adjust the dosage upward.....now at 120. Since then It has been a good experience. Feel centered and have energy. One very good side effect has been pain relief from my arthritis in my knees and back. I have dry mouth with this and every other anti-depressant I have taken. The drug is very expensive."

9 / 10
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  • Jade
  • Taken for 2 to 5 years
  • September 3, 2020

Fetzima (levomilnacipran) for Major Depressive Disorder "I have been on Fetzima for at least 4 years. It worked extremely well for me. No side effects after the initial 8 week period. The last year I have been passing out when I stand to long, random racing pulse, unstable blood pressure. My PCP refered me to a cardiologist who diagnosed possible POTS. After going over my med list he said it's probably the Fetzima as it's listed as a side effect. Geesh, who would have thought! So now no Fetzima and I feel crappy but I don't pass out. There is nothing anywhere on long term side effects so beware."

5 / 10
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  • Wish...
  • Taken for 1 to 6 months
  • February 21, 2017

Fetzima (levomilnacipran) for Depression "So this drug was awesome for everything except it made me rage full. I could orgasm, no sleepiness, felt a little nausea but all meds have yucky side effects that go away after a while. It helped with concentration and motivation!! Wow I was a super star at work. Or maybe I was so used to the others SSRI's that gave me brain fog! I could jump out of bed with no problem in the morning which I never would get before. But it made me snappy, angry, mad and boil my blood! It didn't do well for anxiety. I think it gave me more. This drug must have a stimulant in it, more than one of the other ones that are more sedating. It was also the top highest tier for cost! Too much right now bc its a newer drug. Doesn't work for anxiety!"

7 / 10
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  • Nat
  • Taken for less than 1 month
  • June 13, 2018

Fetzima (levomilnacipran) for Major Depressive Disorder "Today was day 5 of Fetzima and although I was initially a fan, I no longer am one. I definitely felt an increase in energy my first 2 days on it. On day 3 I went back to my usual sleepy self and I also started experiencing some of the side effects. Nausea, increased heart rate, weird anxiety (feeling on edge).. it wasn’t a very nice combo of problems to deal with lol. I’m seeing my doctor tomorrow and coming off of this thing. I don’t think SNRIs work for someone like me who is super sensitive and a highly anxious person."

4 / 10
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  • Alter...
  • Taken for 1 to 6 months
  • October 29, 2016

Fetzima (levomilnacipran) for Depression "Been on 40mg of Fetzima for about 3 months and love it! So helpful for mood and energy. I also have increased sex drive and zero cravings, hence, inevitable weight loss. 40mg is the only dose I have taken, so my experience might be different if dose was higher or lower. This drug reminds me of Wellbutrin (which is NDRI), but slightly less stimulating. Cons: still brand name only, so can be expensive depending on where you live and insurance situation. Also, Fetzima is only approved to treat depression, so no improvement in anxiety symptoms. Vistaril helps with this, especially if you or your doctor are hesitant about benzos."

9 / 10
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  • Less...
  • Taken for 1 to 6 months
  • September 2, 2015

Fetzima (levomilnacipran) for Major Depressive Disorder "I've been on the max dosage 120 mg for 3 months now and feel more human than I have in years. The only reason I didn't give it a 10 rating is because I do have side effects that include: severe sweating, easy bruising, occasional aggressiveness (may just be my personality as I get it under control pretty quickly), my blood pressure (normally very low) has seen a changeable elevation, increased flatulence, migraines linger longer (though I get them less often). While I would love to find a medication that has me feeling this human without the side effects, so far this one has worked better than any of the others I've tried."

8 / 10
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  • Asista
  • October 25, 2018

Fetzima (levomilnacipran) for Major Depressive Disorder "Seriously - where do I begin. I switched after weaning down from zoloft to fetzima, it has been the most horrible experience in my life. The amount of EXTREME RAGE I felt. I had so much frustration and the anger. I felt over things that were only minor inconveniences or annoyance before. It was the most horrifying experience. I snapped at everyone , said things I would never have said in a normal state of mind and cried uncontrollably especially after snapping at people and feeling extremely guilty and embarrassed. I couldn't think clearly let alone get any work done. I stopped taking it after a little over a week . I'm so done with this. It's making me want to give up. Hope I can find something that will work... :( This med has left me feeling hopeless."

1 / 10
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  • Mels
  • May 14, 2014

Fetzima (levomilnacipran) for Depression "I was started on 40mg for 2 weeks..I felt like someone was pulling out the floor from under me and tipping the room. I was decreased to 20mg with unfortunately no improvement. I was previously on Cymbalta that seemed to "stop working". I'm now currently on Paxil which will hopefully help with my sadness and anxiety"

2 / 10
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  • Ssfb
  • Taken for 1 to 6 months
  • April 20, 2015

Fetzima (levomilnacipran) for Major Depressive Disorder "I started with 20mg and stayed on that for 1 month. I didn't see much of a change in with my issues but was a tiny bit better. I went to 40mg for 4 months and I felt some improvement but I became depressed again. I have just started 80mg last week. I was feeling angry and nervous and not sleeping at all for about 4 days. I'm on the 6th day now and those side effects are almost gone. I'll update after a little more time goes by. But I am feeling a little more motivated and awake."

6 / 10
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  • 7071
  • February 4, 2016

Fetzima (levomilnacipran) for Major Depressive Disorder "Have major depressive disorder, PTSD, chronic fatigue, fibromyalgia, and chronic pain, high BP and cholesterol, low thyroid. Started taking Fetzima 20 mg for two days and then 40 mg daily for the past seven days. It stopped the traumatic thoughts at night but need to quit it due to so many awful side effects....slight nausea and light headaches the first few days, awful insomnia, very dry mouth, sore eyes and less clear vision, twitching in corner of eye, hot sweats switching to my whole body feeling cold, muscle cramps in legs, bad constipation. So sad because it was the only antidepressant that worked for the PTSD. It probably did raise my blood pressure but I did not check... got bad headaches like I do when BP is up. Good luck everyone."

3 / 10
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  • Keep...
  • Taken for 2 to 5 years
  • November 15, 2017

Fetzima (levomilnacipran) for Depression "I struggled with symptoms of depression/anxiety since childhood, something that was the result of a naturally sensitive disposition, family history and a history of bullying and self-worth issues. I took this medication for 2 years and it was the only one that I could tolerate well that worked. I had previously been on Lexapro, Prozac, Cymbalta, and Wellbutrin, which I had to discontinue due to seizures, though it was effective. This medication, along with psychotherapy and a lot of work put into rebuilding a social network, helped me recover from very persistent depression. I still struggle with anxiety from time to time but it's nothing major. It gave me the momentum to keep going during a very challenging period of my life."

10 / 10
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  • brbor...
  • Taken for 1 to 6 months
  • February 4, 2021

Fetzima (levomilnacipran) for Depression "I started taking Fetzima in hopes of finding relief from my depression. I have tried meds off and on for nearly 40 years, nothing seems to bring relief. I suffer from severe trauma from things I endured as a child. This medicine made me feel terrible. I have never experienced the type of depression where I couldn't function. This made me literally not want to do anything. I could hardly get up off the couch. Things I would normally love to do, i just couldn't seem to get it done. Then I would beat myself up because I couldn't get anything done. I've stopped the medicine and will go back to therapy."

1 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.