Lupron Depot for Uterine Fibroids User Reviews (Page 3)

• Cho...
• Taken for 1 to 6 months
• March 8, 2018

"I have had like 8 fibroids, super big, started in March 2015, started bleeding, blood clots. I was close to 50 years old, so I found a study, and she recommended Lupron. I'm not gonna lie, had 3 shots, my hair fell out - it's gone, but for the pain I'm in right now, might have to get my 4th shot. This situation changes your lifestyle 100%. Horrible uterus pain is unbelievable. My hot flash/cold flash, worst are without Lupron."

• Nat...
• Taken for 1 to 6 months
• July 7, 2022

"I have had many years of heavy, painful periods. Diagnosed with a bulky uterus (size 16 weeks) with endometriosis and fibroids. My gynecologist recommended Lupron Depot to shrink my uterus before going for laparoscopic hysterectomy. I'm 53 years old. I have had 2 shots now and am going for my 3rd next week. I have had a lot of side effects from this medication: night sweats (not every night, mild), insomnia, no energy, restless legs/muscle spasms, depression (cry every day at least once), and mood swings (my poor family). So next week when I get shot #3, I am hoping that he will have my surgical date booked as I cannot live with the pain and constant bleeding. The shot plus add-back therapy has only given me hope that I will eventually get back to normal and a better quality of life."

• chi...
• May 15, 2021

"I took Luprodex 3.75 mg injection for 5 months on a monthly basis to reduce the severe cramps and pain associated with monthly flow. The first month of the injection was still painful, but the subsequent months were normal, and I also ovulated well in month 4. Then, after the last dose, it took just 6 weeks before my period returned. It was quite normal but with a very light right abdominal cramp. I will do a scan to check if the bulky uterus has reduced because I want to conceive too. One important observation is that it did not stop my period for those months. I usually see my period each month but did not see it the next month when I stopped the injection. It was a beautiful experience, though I had severe leg cramps/arthritis."

• Mon...
• Taken for 6 months to 1 year
• March 30, 2023

"I’ve had Lupron Depot for six months, with no reduction in the size of my fibroids. It wasn’t hell with Lupron Depot, but my sex life was non-existent, the heat flashes were constant, and it didn’t help the various pains I was experiencing from my large uterine fibroid (>10 cm). I also noticed that my knees got weak, and I constantly had back pain. I’m 29 years old, so this is alarming."

• Ann...
• Taken for 1 to 6 months
• October 12, 2022

"Update from post Sept 23. It's been over 1 month since my Lupron shot, and I have been bleeding continuously since Sept 21st. On and off from light spotting to filling pads every 30 minutes with large clots. I can tell the shot has affected my hormones as I get hot flashes through the night to the point of sweating, I lose my train of thought and I forget easily. My Gyno just told me to increase iron intake from 150 to 300 and take TXA when needed. I completed 3 iron IVs to help build my blood. Hopefully, I will stop bleeding for my surgery on Nov 14th."

• Ann...
• Taken for less than 1 month
• September 23, 2022

"Back in Sept 2019, I had a submucosal fibroid at 1.3 cm in size. I was offered Lupron back then but didn't pursue it. Covid hit, and I didn't end up doing anything other than iron supplements. In Dec 2022, I decided to see a naturopath as my symptoms were getting worse (heavy periods, clots, extreme tiredness, pale skin, painful intercourse). In July 2022, I had the worst period ever, which put me in the hospital needing two blood transfusions. I had an ultrasound that confirmed my 1.3 cm fibroid had grown to 8.3 cm. Due to my condition, we agreed to have a partial hysterectomy. Surgery is Nov 14th. I took Lupron 11.25 mg shot on Sept 6th. I will have three iron IVs prior to my surgery to build hemo (Sept 20, 26, Oct 4) before surgery. On Sept 22nd, I started bleeding like a normal period, but day three now is heavy with clots. I am on tranexamic (2/8 hrs) but will change to 2/6 hrs as the bleeding isn't slowing down. No other major symptoms yet other than 2-3 migraines. Will re-post with updates."

• Anonymous
• September 2, 2021

"I have not had the injection yet but am taking the one-month version today. I am nervous after reading these things. I have over 20 fibroids. One that is 10 cm, I can feel touching my rib cage... YES, my rib cage. This will be my second fibroid surgery, but this one is worse. Has anyone had a provider say to use progestin (low dose) to help minimize the side effects? I was told you should not use estrogen-based BC with these products. Will I need calcium/vit D for my bone health? I am worried about hair loss. The anemia I have has already made my hair fall out. I don't need any more help with that. Please share your experiences."

• Anonymous
• November 17, 2009

"Hot flashes throughout the day; moodiness and moderate depression, and moderate fatigue."

• Sul...
• November 20, 2015

"This medicine has given me horrible headaches. Lost a lot of hair, gained weight, insomnia."

• Mcl...
• April 25, 2017

"It caused me permanent hair loss."

• Anonymous
• Taken for 1 to 6 months
• July 1, 2016

"Lupron did not work on me. I still had heavy periods and severe cramps. My fibroids grew and didn't shrink. I was very angry that the shot didn't work."

• Tam...
• Taken for 1 to 2 years
• December 15, 2016

"Finally, something that worked for my fibroids! Yay."