Lupron Depot for Uterine Fibroids User Reviews (Page 2)

• lup...
• Taken for 1 to 6 months
• November 7, 2018

"I had very heavy periods. My doctor offered a Lupron shot. I decided to go with 2 Lupron shots hoping it would shrink my fibroid. Instead, my fibroid grew bigger. It caused me horrible headaches with the strongest painkillers not helping. After each shot, my period would not stop for a month (at least it was not heavy). Hot flushes were horrible. Good night's sleep was gone. I would wake up multiple times a night, all drenched in sweat. After the effect of Lupron wore out and my period restarted, it was as heavy as before. The only benefit I got was not having a period for a few months (with some bleeding in between), but at a very high price (side effects and actual price). I think, as heavy as my period was, it was better to have my period for a few days a month than have frequent very bad headaches and constant hot flashes. I would not recommend it based on my experience. I would not have it done if I had to decide today."

• cmf...
• Taken for 1 to 6 months
• August 19, 2015

"I had the 3-month 11.25 mg on 3/30/2015 to shrink my giant fibroid to the size that the laparoscopic myomectomy can be performed. I had no symptom of side effects for the first month and also had my period, but ever since the second month (May), the side effects have been really hitting me hard; including hot flashes and night sweats. I had my surgery at the end of June, and my doctor confirmed that I had reacted to the Lupron more than expected, as the fibroid not only shrank but part of it was degenerated. So, instead of a 2-hour operation, it ended up being a 6-hour one. Now, it's been 5 months, and the Lupron is still lasting (period still not back yet); don't know when it will be gone..."

• Ves...
• Taken for less than 1 month
• October 14, 2020

"I developed several fibroids in my late 40s that caused very heavy bleeding. I opted for a hysterectomy and was given one shot of Lupron about 3 months prior in the hope that it would shrink the fibroids before I had surgery. I cannot say that it shrunk them (my uterus size was comparable to a 5-month pregnancy), but it did stop my periods immediately and that made it worth it to me. The only side effect I ever experienced was extremely painful cramps a few times (once so bad I had to pull off the road because I was driving). Still worth it."

• Ang...
• April 10, 2010

"I love that it completely stopped my outrageous heavy bleeding, which in turn made me anemic. So I am happy for that. However, the only side effect that I am experiencing is super dry skin on my arms, neck, and face... I feel it is aging me overnight. Some constipation, and not really hot flashes, but warm spells every now and then. Can't wait for surgery to get my hormones back to work."

• Lin...
• Taken for 1 to 6 months
• January 11, 2021

"This ruined my life! I don't recommend it. Get a surgery, and if you get pregnant, get a C-section. This drug (6 injections) was recommended by my doctor. The only choice he gave me, and he didn't tell me the lifetime side effects. There was just the 6 months suspension of periods (sweats, moods). In 2005, I was 32 years old, recently married, and we wanted to have children. Now, I'm 47 years old, we didn't have children anyway, and I don't lubricate, it hurts when I have sex, and my libido is gone, all this for the last 15 years, and I think for the rest of my life."

• Hop...
• Taken for 6 months to 1 year
• October 14, 2019

"I am 48 years old. I was bleeding nonstop for over a year due to a large fibroid...and I was in much pain. In January 2019, I started my Lupron 3-month shot, and I’ve had two more shots since then (every three months). I have not bled since January. My 6 cm centrally located fibroid shrunk to 5 cm within 6 months. My uterus reduced in size from 10 cm to 8 cm. I was anemic, but my blood levels are back to normal now. I do get hot flashes often. My hair is thinning and dry. My biggest problem is bone pain in my fingers/toes. But that’s nothing compared to how bad I felt when I was bleeding. I have been very moody at times over the past 10 months. I’m supposed to schedule one more dose of the shot before my doctor will decide what to do next, hoping I can just start menopause so I don’t have to have surgery. I also have multiple sclerosis. But so far the MS flare-up, due to this fibroid, is minimal."

• Ano...
• Taken for less than 1 month
• May 4, 2016

"Received a 3-month shot two weeks ago to stop heavy menstrual bleeding in preparation for a hysterectomy next month. My period started, and the bleeding is just as extreme as usual. No relief in blood or pain with this drug. Have experienced hot flashes (minor), headaches (minor), night sweats, nausea (moderate), and have pain in the upper right back area. Will be seeing the doctor later this week to get checked on. I know it's early in the process, but I'm disappointed. I took it knowing about the side effects, but was willing to go along with them to get my bleeding under control and to build up my iron stores."

• Kel...
• Taken for 1 to 6 months
• February 11, 2019

"I got the Lupron 3-month shot in January. I’ve had so far now the hot flashes, some abdominal pain, depression, and now these headaches I keep getting. The bleeding stopped, which is the good part. But the headaches have got to go. I don’t like to have to keep taking medication. Those are my only issues."

• KYR...
• February 2, 2016

"This drug was the worst form of treatment for my multiple symptoms - daytime hot flashes and steady period was not worth it. I was administered this drug in 2008, and since then, my life has never been the same. Forgetfulness covered in laughter by co-workers; poor cognitive skills, no sex drive, and no desire to be touched. Headaches, blurred vision; quick weight gain, and most of all, I quit my job, and I'm still trying to figure out why when I was financially stable. Who was I? Something in my brain is out of sync. I was not a person that took medicines. The male doctor pushed this on me, and I was a patient with that organization for over 10 years, and I was the only 32 years old and super active!"

• Mel...
• Taken for less than 1 month
• December 16, 2016

"My rating is based solely on symptoms, I am unsure about the effectiveness, being that I haven't checked my fibroid size yet to see if it has suppressed. To furthermore explain, I was diagnosed with a large fibroid, about 10 cm (outside my uterus), through a CT scan. I'm 28, no children, but hoping to conceive in my early 30s, therefore, I chose to go on with the Lupron shot (3.75) to hopefully shrink the fibroid for surgery early next year. After reading the side effects, I was terrified and put this off for a year and a half. I have had one symptom, and that is I do notice that my face is a bit clammy/dry. Just wishing I never put it off due to fear. I just finished my first month. Will update how month 2 went in January!"

• Mlh...
• Taken for 1 to 6 months
• March 24, 2022

"I wanted to share my story also for people who are considering trying this out. I had big fibroids and was scheduled for a laparoscopic hysterectomy. My doc put me on Lupron for 4 months before the hysterectomy. She felt it would help me in hopefully shrinking my fibroids down to help with surgery. She wanted me to take the 3-month dose. I am very scared of side effects and really don't like taking anything. I did my research and decided I only felt comfortable taking the once-a-month lower dose Lupron shot. I was afraid to even try that. I was on Lupron for 4 months and I did bleed for the first month on it, and then my bleeding and periods stopped after the first month. My only side effect was hot flashes! But as time went by, they seemed to get a little better and they calmed down some. It wasn't too bad, but definitely uncomfortable at times. That's all, though! So happy that I moved past my fear and tried it. It helped stop my periods and I was able to get the laparoscopic hysterectomy done."

• Jen...
• Taken for less than 1 month
• August 20, 2020

"This is user Jennybean from the review below (August 12, 2020). I could not log in with that username, so here's my update: I got my first injection on 08/14/20. Ultimately, I am getting the 3 month 11.25 MG Kit. So I assume I will get 2 more shots. I got the shot in my butt cheek and it did not hurt or flare up. The side effects for me so far: a couple of short-lived hot flashes here and there. Fatigue and my boobs are sore (like before a period and wearing a bra sucks as a result). These effects are medium-mild and are not overwhelming. I'd say the fatigue and breast tenderness are the most bothersome. I expect I will be adding to my list of side effects as we go on. The last thing I'll add is that my biggest fibroid is 7 cm and my uterus never shrunk after I had my preemie son at 28 weeks pregnant. So basically, I still look six months pregnant 6 years later. That's why I'm on this medicine. I need to shrink my uterus and fibroid in order to have a less invasive partial hysterectomy (leaving my ovaries)."

• Han...
• Taken for 1 to 6 months
• July 25, 2019

"I’ve been on Lupron Depot for 4 months for heavy bleeding from a fibroid and extreme pain due to endometriosis. It has stopped my uterine heavy bleeding, and I have increased energy from not being anemic any longer. However, I have experienced hair loss, generalized whole body muscle pain and stiffness, as well as hot flashes, extreme jaw tension, teeth grinding at night, and occasional insomnia."

• Kia...
• June 30, 2018

"My experience was horrible. My OB/GYN recommended Lupron for my fibroids. I have 1 large one the size of a grapefruit, 3 the size of tennis balls, and many pea-sized. Surgery was not an option. I get Lupron shots 1 time a month for 6 months. I had 13 acne cysts in total on my face that I had to have surgically removed (over time). I gained 30 pounds almost overnight, and it took me 3 years of intense dieting to get this weight off. My body thought I was going through menopause, so I had the hot flashes as well. I would not do it again. I spent a fortune only to find out after 6 months and all of this that the tumors were the same size. Years later, I am having health issues and wondering if related to Lupron usage."

• Sic...
• Taken for 1 to 6 months
• September 24, 2020

"My experience with Lupron Depot has been challenging. I have side effects of memory loss, trouble breathing (did not have this before), heart palpitations just about every day (worst at night), nausea, extreme tiredness (daily). Periods had stopped before but started up when taking Lupron Depot (very light to spotting). I am in my second month of the 3-month injection, and I now have body aches and hot flashes every 15 minutes all day, which have subsided to every 30 minutes to an hour as I get close to wearing off. I will not know if the fibroid has shrunk until after the 3 months have passed. Not interested in sex, so do not want to be touched. Very sensitive since the shot and not having a taste for really anything. Feet swollen like Ms. Piggy. Would I get it again? Heck NO! I would stop eating red meat first and drink a healthy smoothie with raw veggies and fruit first."

• KSt...
• September 25, 2022

"Do not be afraid of this drug. I am in my forties and have several fibroids. I was bleeding continuously for 8 months and needed a hysterectomy. My hemoglobin at the time was too low for a successful surgery, so my doctor suggested Lupron. It worked wonders. Bleeding stopped. Bloating went down. I'm sure my fibroids shrunk also. Hemoglobin recovered from a 6 to a 12 in just 4 months. Soon I will have my laparoscopic hysterectomy. Lupron saved me."

• rub...
• Taken for 1 to 6 months
• July 11, 2018

"I had 8 tumors in my uterus, and the doctors told me there was no way to remove them. They gave me 2 shots of Lupron, and I started losing my memory, and the bleeding increased. I did a search for doctors that remove the tumors, and I found one. He took out the tumors, I was able to keep my uterus and have had no problems since. I thank God every day for this doctor! The only bad thing is, thanks to the drug, my memory is damaged for life."

• Tri...
• November 29, 2019

"I started the shot in June 2018 due to having multiple fibroids on my uterus. I was bleeding very badly for months nonstop. I had the Nexplanon (BC) in and took that out to see if the bleeding would stop as well. I took the shot for 6 months, and then the doctor removed my fibroids located outside the uterus on November 29, 2018. The doctor stated that he could not remove two fibroids in my uterine cavity and that he would keep an eye on them. As time went on, I was still bleeding badly and got back on the Lupron injection in August 2019. I had another surgery on November 7, 2019, and my fibroids located in the uterine cavity shrank. I did not get the shot in November and had a cycle on November 23, 2019. It was heavy at first, but it stopped after 5 days. My fibroids have grown back since last year and are located on the outside of my uterus. The shot may help some, and it may not."

• Jen...
• Taken for less than 1 month
• August 12, 2020

"I am getting my first injection, 11.25 mg/3 months, at the end of this week for uterine fibroids. I am scared of flipping my body into fake, sudden menopause. I need to shrink a fibroid in order to have a partial hysterectomy, and this is the route I chose despite being wary. I will come back to update. So far, just getting the approvals to get this stuff has been quite challenging! I should be ending my third month on Lupron, but it took that long just to get it. Good thing I didn't lose too much blood in the meantime on a period (which is what prompted me to seek this treatment in the first place). Again, I will come back and provide my experience once I get my shot this week."

• Lov...
• Taken for 1 to 6 months
• March 10, 2017

"I was on Lupron a few years ago. For chronic pain, multiple cysts, I was bedridden a week or two of every month. This injection saved my life back then. I lost coverage, so I stopped. Now I have coverage and decided to try it again... it's not working this time! I'm in pain all the time still. I have trouble sleeping at night or staying asleep, my libido is gone... and I'm in the 4th month of treatment and started bleeding and have really bad pains again... and my hot flashes are back. The first month is the worst! The worst period of my life... but there was no bleeding until now... so I would recommend trying the once-a-month doses first."

• Mar...
• Taken for 1 to 6 months
• September 28, 2024

"I have been on Lupron for 4 months, about to have my fifth shot. I have a 10 cm submucosal fibroid which was causing pain, severe bleeding, and anemia. Since starting the Lupron, my migraines increased by double (I had to switch meds so I could go to work). I’ve gained 10 pounds, I have night sweats, hot flashes during the day, my mood gets angry and sad the week after the shot, and now my hair is thinning. I also am still bleeding daily (spotting). I was put on progesterone to offset some of the side effects. I have two more shots until my second surgery, and I can’t wait to be off this medication."

• Ann...
• Taken for 1 to 6 months
• November 19, 2021

"Lupron did not work for me. I took this medication as a last resort prior to having surgery to try and stop further growth of my already large fibroids and stop the hemorrhage-level bleeding that I was regularly experiencing. This was an injection taken once every 3 months. While taking, my bleeding continued to get heavier. I had all the side effects and none of the stated good effects. The doctors don’t tell you that this medication may not work, and when I told my doctor that it’s not effective and I continued to have heavy bleeding, she still wanted me to continue taking this very expensive medication. For me it wasn’t worth it. The mood swings alone made me feel awful, I had memory fog, and the hot flashes were so intense. Take with extreme caution."

• KDI...
• Taken for 1 to 6 months
• January 18, 2023

"Took Lupron injections for several months, prior to surgery to reduce my fibroids. It did the trick, and the surgery was successful. Within two years, I got pregnant and had my daughter. Without Lupron and my procedure, it may have never happened. Had no issues with Lupron, except for the hot flashes I was forewarned about."

• Flo...
• Taken for 1 to 2 years
• August 9, 2021

"The Lupron injection was a lifesaver. In November 2019, I was 50 years old, and I had been bleeding for 75 days due to uterine fibroids. My hemoglobin was down to 5.1, and I had to have blood transfusions in the hospital. So far, so good, no bleeding at all until today, when I started bleeding again for the first time since November 2019. I'm now almost 53 years old, and I'm scared to death. I have to go to the doctor on Thursday. Has anyone else had their periods restart after so much time, not having them following the Lupron injection? I know the injections wear off, I'm not sure if they will administer more to stop the bleeding now?"

• Neu...
• Taken for 1 to 6 months
• July 16, 2023

"I was put on a Lupron Depot shot monthly, with add-back hormones because of my age (29), after trying a number of unsuccessful treatments for heavy bleeding from fibroids (multiple, 10 cm largest). The first period on Lupron was heavier than normal, but I did not have one again until 3 months after my last shot. I only took it for 6 months because the side effects were horrible, but on the bright side, I didn't have a period for 9 months. The side effects I experienced were extremely dry skin to the point of peeling off my face in chunks, zero sex drive, significant weight loss, and depression. I was put on a higher dose of add-back hormones to try to address the side effects, but ultimately stopped filling my prescription as I wanted to feel like myself again. To date, it is the only intervention that has controlled bleeding from my fibroids, other than the Kyleena IUD. Fibroids have grown back since stopping Lupron."