Deplin for Depression User Reviews (Page 4)

• Bai...
• Taken for 6 months to 1 year
• July 23, 2022

"I take Lexapro 20 mg, which works well for my anxiety but not quite so well for my depression, and I was always tired. I started taking 15 mg Deplin and quickly started to feel more energy. I have more motivation now and just feel better in general. I do have the homogenous C667T MTHFR variant and also had a slight folate deficiency before starting."

• Amy...
• Taken for 1 to 6 months
• June 11, 2022

"I started taking Deplin along with my other meds for depressive disorder and CPTSD. It may have boosted my energy, but it caused extreme anxiety. I haven’t felt as panicky while out in public in years as I did while taking Deplin. The anxiety stopped once I stopped taking it."

• Jin...
• Taken for 1 to 6 months
• May 18, 2023

"Deplin may have saved my life from menopausal depression. I am heterozygous for the C677T polymorphism in the MTHFR gene, but I never had mood issues until late peri-menopause (2023). In late March, throughout April, and half of May, I experienced serious mood changes related to lower endogenous estrogen. Despite having an estrogen + doctor and good HRT, my mood deteriorated to the point where I went from highly productive and functional to extremely lethargic, unmotivated, exhausted, and deeply emotionally vacant. I felt like a shell of myself. I told my new psychiatrist about the genetic test from 2018, and he recommended Deplin 15 mg in addition to the Lexapro I had started a year before. I was skeptical, but about 3 weeks after starting it, I noticed a significant improvement in my mood, sleep, energy, and motivation, and it remains. If you’re in menopause and having difficulty with your mood, you may want to ask your doctor about Deplin and/or the genetic test."

• Goo...
• November 11, 2016

"I've gone through deep shit, to the wall depression - had ECT, et al. while on meds. Went off and have NOOOO regrets b/c I finally started having feelings again (after 25 years on meds)... But I went through deep retaliation at work for speaking out against a bully, and the PTSD from that became deeply real only after two lawsuits were settled and every state/federal complaint was successfully settled. I won... but the PTSD won even more. And you think you can find a shrink who looks at alternatives to antidepressants? HA! My only salvation came in the form of my doctor, an internist, who suggested I go to ER b/c of thyroid stuff. While 5 days on a med/surg unit was not free from shit... I got connected with a shrink who prescribed THIS."

• Lsk...
• Taken for less than 1 month
• July 10, 2016

"Terrible! I was on it 3 days while also on Viibryd, and it caused me SEVERE anxiety. I was found to have a compound heterozygous gene mutation, and the psychiatrist thought this should help. Wrong. I also found out through the gene test I cannot take SSRIs. Viibryd is a hybrid SSRI. The combination was bad news for me, and I had to stop the AD cold turkey because the blast of Deplin apparently caused me serotonin overload. Still struggling 4 weeks later. From what I've researched, L-methyl folate should be started at SMALL doses, like 400 mg, NOT 15 mg (Deplin). Lord!"

• kva...
• Taken for less than 1 month
• December 16, 2020

"I'm tapering off Prozac and am only taking 2.5 mg. I prefer not to go on SNRIs or SSRIs. I asked my psychiatrist what I could try instead. He suggested Deplin 15 and gave me 12 capsules. I have taken 6 so far, and the only thing I noticed is that it slows my lower GI tract. Hoping for better feelings in the future."

• TZT...
• Taken for 1 to 2 years
• April 9, 2018

"If you are taking Deplin because of the MTHFR genetic abnormality, you were misled by your doctor(s). This genetic test is being pushed by the psych field even though it has not been proven. Look up the studies on MTHFR and you will soon learn that most of what you read about are myths. That being said, Deplin does have its benefits."

• Mwi...
• Taken for 1 to 6 months
• August 17, 2018

"Holy moly Deplin has changed my life. I took SSRIs that kind of worked but not totally. Started taking Deplin and it has just given me the rest of my life back."

• Anonymous
• September 17, 2009

"No side effects, many more plus/up days than before. Seems the longer I am on the Deplin in conjunction with my antidepressant, the better my moods and overall feeling gets."

• Sco...
• Taken for 2 to 5 years
• June 13, 2019

"I have been taking Deplin 15 mg daily as a supplement to other drugs for my bipolar illness. It works well, and I have no noticeable side effects from it."

• Sto...
• Taken for 1 to 6 months
• July 29, 2016

"It has helped me quite a bit, although it doesn't seem to have antidepressant effects. It's definitely helping me think better - I'm not confused anymore."

• Anonymous
• July 28, 2009

"This has helped better than anything else I have tried."

• Lor...
• Taken for 1 to 2 years
• October 29, 2019

"Taken Deplin for MDD for nearly 2 years and no change in my depression. I recently stopped taking it to save money."

• JSa...
• Taken for 1 to 6 months
• July 2, 2019

"The medicine, after two weeks, I felt disoriented, confused, and flat, definitely not any help, more of a deterrent."

• Tre...
• Taken for 1 to 6 months
• March 4, 2019

"We observed no positive contributions to my treatment of depression. No effect at all. Deeply disappointed."

• Ric...
• Taken for 6 months to 1 year
• July 21, 2016

"Long history of medication-resistant recurrent major depression. Tried Deplin 15 mg daily for 6 months. No improvement at all seen with Deplin. Total waste of money for me."

• mik...
• Taken for 1 to 6 months
• May 25, 2016

"Not worked for my depression. Zero effect."

• Cou...
• Taken for 2 to 5 years
• June 27, 2017

"Started taking Deplin to curb the side effects I was feeling on Lexapro. I'm not really sure if it was working or if I just thought it was working. It also cost a lot of money."

• joy...
• Taken for less than 1 month
• April 19, 2016

"I'm just starting Deplin. I need energy. I've been taking Wellbutrin for two years now, 100 mg, 3 times daily. I pray it works for my energy level."