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Hyaluronidase User Reviews & Ratings (Page 3)

Brand names: Amphadase, Hylenex, Vitrase Hydase

Hyaluronidase has an average rating of 2.0 out of 10 from a total of 71 reviews on Drugs.com. 9% of reviewers reported a positive experience, while 89% reported a negative experience.

Reviews for Hyaluronidase

  • Dora
  • Taken for 1 to 2 years
  • June 23, 2022

For Dissolution of Dermal Filler "I got a tiny amount injected in my top lip to dissolve an unwanted amount of filler and I ended up with systemic damage throughout my whole body. My face completely collapsed and all of my tissues feels like they’re tendered and are really porous. My gums hurt, my eyes have shrunk and caved into my skull. I lost my whole identity to this enzyme and I don’t know how much time I have left to live if this damage doesn’t stop, since it feels like it is dissolving me while I am alive. The safety regulations regarding this drug as a dermal filler dissolver is not existing and I am scared it won’t be for years. All I can say is do not under any circumstances use Hyaluronidase."

1 / 10
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  • Anonymous
  • Taken for 6 months to 1 year
  • June 25, 2023

For Dissolution of Dermal Filler "I dissolved my fillers 7 months ago, and my face aged drastically. Now it seems like the volume is coming back but suddenly I developed arrhythmia. The doctors cannot find a reason for the arrhythmia after many checkups. I suspect it has something to do with hyaluronidase. I researched, and I discovered that there are hyaluronidase inhibitors like quercetin. I will give it a try, and I will send an update. It seems that turmeric and chondroitin inhibits its activity, too. I am also doing a colon cleanse, trying to get hyaluronidase out of the system. I hope this information will help others. I am still researching ways to get it out of my system. It seems that blueberries and green tea help, too. I will continue with research, there should be something that can help to get it out of the system."

1 / 10
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5 Report
  • Anonymous
  • Taken for less than 1 month
  • May 15, 2022

For Dissolution of Dermal Filler "Caused a strange disease that appeared 8 months later. Strange randomized swellings on my lips and area. Starts with tingling and then swells greatly. Lasts minimum a few days, happened every week. Could be nerve related as felt tingling in chin area as well. Also area that was dissolved did not go back to "normal". It grew a new visible vein, and looked like I had aged 20 years."

1 / 10
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9 Report

Frequently asked questions

  • Anony...
  • Taken for 10 years or more
  • August 21, 2022

For Dissolution of Dermal Filler "Vile vile vile drug, I’m not sure it’s even legal to use! Destroyed my face & my immune system! My skin just melted after the doctor used this! My skin suffered huge indentations, sunken eyes, dry eyes & saggy skin. My natural elasticity just disappeared over a few weeks. This injection is awful! And it seems to cause much longer term issues. I had this injected about 10 years ago & there is still no research into the long term side effects, because those injecting it are making too much profit, so sadly don’t want to invest in the impact of those suffering!"

1 / 10
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  • Evelyn
  • Taken for 1 to 2 years
  • June 27, 2022

For Dissolution of Dermal Filler "I experienced a nightmare from hyaluronidase. A year ago I had Hyaluronidase in my face to reduce fillers. After that I felt a burning sensation and terrible nerve pain. Dry eyes, nose, mouth, tachycardia, etc. It's been a year and I'm still suffering from pain, especially dryness in the mucous membranes, right now I can see dots and lines and blurry. Please don't use hyaluronidase even if the doctors say it has no side effects. I used to be healthy and never had any problems ."

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  • My th...
  • August 10, 2022

For Dissolution of Dermal Filler "As a long time systemic sufferer from this awful stuff I have used all my past year studying science reports on hyalase which mostly are propaganda. No scientist or surgeon are willing to study negative long term effects if you get this poison in your bloodstream. Here is my conclusion about what happens: -The Hyalase addressing the filler enters your overall body tissue via the vessels. -The filler starts the dissolving process which can go on for years. Fillers are hard to dissolve and will always leave traces of particles. -Filler (or particles left) is trying to destroy itself - often in waves/ flare-ups. -Since I believe everything in the body is connected I believe everywhere the hyalase has been in contact with also have the same flare-up destruction when the filler (or leftover particles) again and again tries to self-destruct,- hence the overall burning."

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  • Anonymous
  • Taken for 1 to 2 years
  • March 24, 2023

For Dissolution of Dermal Filler "Hyaluronidase destroyed my life. After taking hyaluronidase my face lost volume and the face changed shape, my eyes felt like they had sunken into the socket, the skin on my face, and my body changed and become thin and spongy, and my joints cracked and hurt and my vision is now bad and I have lost all my hair."

1 / 10
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  • Devas...
  • Taken for 1 to 2 years
  • July 12, 2022

For Dissolution of Dermal Filler "Now I'm 1 year in- Hyalase is dangerous. I obviously got this poison in my blood and it rapidly attacked absolutely everything in my body - from the collagen / connective tissue to the intestines. Still I have this suspicion that the enzyme might along the way left the system and that the constant feeling of being sick is the continuous swelling and dissolving of the filler in my face. I don't tolerate chemicals well and however you look at it the Restylane is fabric made. I suspect the rapidly dissolving filler ( which actually is chemical ) affects my whole system now. My blood work shows signs of alcohol and tablet abuse. I never touch alcohol and never take pain killers even though the burning pain in my face and eyes makes me scream sometimes. The continuous poisoning of my body has also now made my thyroid gland malfunction and the hormone production is declining. Maybe being allergic to chemicals has contributed to severe complications in many of us? Thoughts?"

1 / 10
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7 Report
  • HA to...
  • Taken for 1 to 6 months
  • December 20, 2022

For Dissolution of Dermal Filler "The so called surgeon used more than 1000 iu in one session to dissolve the remaining filler in lips and nose which caused immediate and visible change in the appearance of fat on the face. One day after my face looked saggy and as if I would’ve lost weight overnight. After one week I looked terrible, my eyes started sinking all the fat in my left cheek disappeared, I developed under eye bags and folds in my upper eyelids also fine lines around my eyes appeared. It’s been one month and I don’t see any improvement, to the contrary I am worried because now my eyes look even more sunken and they are dry, fine lines under my eyes look each day worse. Stay away ofrom this product."

1 / 10
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  • Rocky
  • Taken for less than 1 month
  • October 29, 2021

For Dissolution of Dermal Filler "I had a vascular occlusion from Voluma in my left cheek. They used hyaluronidase in my cheek. I’m two weeks out. I haven’t seen any facial deterioration. But, I’m scared now. Both my doctors told me that there were no side effects of it. I have some bad scars from the necrosis I got from the occlusion. I had no choice. Wondering if I should dissolve the other cheek"

6 / 10
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  • Tina
  • Taken for 6 months to 1 year
  • October 8, 2022

For Dissolution of Dermal Filler "The hyaluronidase completely damaged my face. I had used cheeks filler years ago and there was small lumps left on the right side.. the doctor used hyaluronidase injections to dissolve them. Few days later my eye lid was sagging then my cheek dropped.. after only one week l had an empty cavity around my right eye, with a hollow cheek and as if this side of my face is pulled down. I suddenly aged! And on only one side. It kept dropping down. A month later the eyelid dropped completely affecting my vision. I had to undergo a blepharoplasty surgery. The damage continued though! Visual impairments, dropping in the muscle, sunken eye.. 11 months now and it’s a nightmare."

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  • Muche...
  • Taken for less than 1 month
  • April 4, 2022

For Dissolution of Dermal Filler "I had fillers in September 2021 (end) for the very first time in my life. The right side looked over filled/swollen. I keep going back for follow-ups and was told to massage the area. It didn’t help so in November 2021, the fillers was dissolved. I was assured that there would be no side affects to dissolving the fillers. I’m now left with a dent the size of a large thumb print under my eye."

1 / 10
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6 Report
  • Burns...
  • Taken for 1 to 2 years
  • December 20, 2022

For Dissolution of Dermal Filler "Beware beware! This is an acid that burns down everything it comes in contact with in your body if you get this is in your vessels! It burnt down my thyroid immediately and I felt it! The burning in my throat was so bad I thought I had caught covid! Now I have got hypothyroidism and must take medicine for the rest of my life! If after having hyaluronidase you never felt your throat burned, but feeling very weak and noticing your body sweat is almost gone? Your body mass is changing, and you can't figure out why? Well, guess!"

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  • pmoreh
  • Taken for 6 months to 1 year
  • March 17, 2023

For Dissolution of Dermal Filler "I had the enzyme injected multiple times (i.e., large amounts over many sessions) to help reverse a bad aesthetic outcome. I look much better, and no harms done. Without this treatment option I would be miserable. So happy to have the awful filler removed."

10 / 10
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  • Worke...
  • Taken for less than 1 month
  • August 21, 2022

For Dissolution of Dermal Filler "I had my cheeks dissolved 4 days ago and so far so good. I am not experiencing anything that has been described above. No burning, no dry eyes, no overly aggressive volume loss or dents. I feel he dissolver did what it was supposed to do. I had large amount of Juvaderm Voluma in my cheeks for over 2 years that had started to harden and look very odd when I smiled. Getting them dissolved was the best thing I have done. I look like myself again. It was done by a board certified PS, 75 units in each cheek diluted with Lidocaine. I’m very happy with the results."

10 / 10
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  • Cherish
  • December 28, 2022

For Dissolution of Dermal Filler "I had hyaluronidase a week ago. Worse experience of my life. On the left side of my face I have hollowing of the eye. On the right side, It is puffy and sticks out very badly. Plus, I have bruising and pain I immediately knew after 3 days the procedure was done incorrectly. The company is supposed to have 14 years of experience. I had to reach out to another company who came out of hours to look they said it'd been done incorrectly. I'm going there Friday to correct the work done the week before. I now have to start the process again. It's caused anxiety also pain in other areas. I will never have fillers again for this to happen, disturbing all the young people and filling their faces they will regret it over the next few years. As they age, skin stretches get loose. I will never put myself through that again. No to fillers. They are not safe I now have to live with the damage"

3 / 10
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  • flora
  • Taken for 1 to 2 years
  • September 23, 2022

For Dissolution of Dermal Filler "Wish I could post my before and after. In Tn there are no doctors to consult about non surgical procedures. A doctor in SC told me not to have Voluma, but I didn't listen. The bullying I've endured by men and women in the US caused me to be insecure and strict with my face. A small asymmetry is normal. An injector did one syringe Voluma on my cheeks and I already had big cheekbones I looked horrible. I had 4250 dollars of hylenex by a nurse and my left under eye is sunken now with a deep dent, it's no longer soft smooth with my natural fat as it was. It's been 19 months since then and the Voluma was dissolved from my left cheek, but not from my right one completely or I can't tell what's going on, my right cheek looks puffy my temple looks puffy all of a sudden and my skin on my left side is no longer plump. I take collagen pills and have raw milk which helps my skin so its not aged but I don't see my natural HA coming back. My right side is smooth and even puffy my left is thin."

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  • Las...
  • February 9, 2021

For Dissolution of Dermal Filler "Correction on my review- Hyaluronidase was NOT taken for 1 to 2 years as it states on top of my review. It has been a year SINCE I was damaged by hyaluronidase."

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  • Melanie
  • Taken for 6 months to 1 year
  • August 22, 2021

For Dissolution of Dermal Filler "I had hyaluronidase under my eyes to help remove filler under my eye Well MY Eyes Swelled Up , almost shut for 6 months The lady told me I was Allergic to it. Be very careful"

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  • Anonymous
  • Taken for 1 to 6 months
  • October 23, 2022

For Dissolution of Dermal Filler "Systemic effects. Burning skin all over my body, especially arms, hands and chest, saggy skin. 1 month post HYA, still burning. This is so awful"

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  • Anonymous
  • Taken for 6 months to 1 year
  • December 25, 2022

For Dissolution of Dermal Filler "It destroyed my face and body. No longer have a good life."

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  • Lee
  • Taken for less than 1 month
  • November 14, 2022

For Dissolution of Dermal Filler "I had filler dissolved with hyaluronidase. It destroyed my face. It aged my face tremendously. Do not use it."

1 / 10
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  • Anonymous
  • February 17, 2010

Hylenex (hyaluronidase) for Hypodermoclysis "Easy. Fast. No problems."

10 / 10
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19 Report
  • xxmad...
  • Taken for less than 1 month
  • July 18, 2022

For Dissolution of Dermal Filler "This is a good product Your skin will look different after the filler is dissolved because you’re so used to seeing it filled. This injection is life saving"

10 / 10
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1 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.