Trulicity and Fatigue: What Users Say (Page 2)

• Anonymous
• Taken for 1 to 6 months
• February 11, 2020

For Type 2 Diabetes "I have Type 2 Diabetes, and have not been taking Janumet like I am supposed to. My Endo gave me samples of Trulicity (low dose) to try. This week will be injection #8. I forgot to check my A1C prior to starting it, but I will check it in April. I have lost 17 pounds, with little exercise. I don't have an appetite most days (not complaining), but eat small meals/snacks. When I do eat, I get full quicker, and have noticed a slight nauseated feeling when eating something greasy. I do feel fatigue, but can't totally put that on the medication. My A1C is 6.6, and my doc said that I have to lose 5% of my body weight in order for me to not have to worry about having Type 2 Diabetes anymore! Thanks, Trulicity!"

• Sic...
• November 22, 2015

For Type 2 Diabetes "PART 1: Been on Trulicity for approx. 6 weeks (2 weeks at .5, the rest at 1.5). I FEEL LIKE CRAP. No weight loss, but sugars are running low, sometimes too low (60s). The first 2 weeks were like everyone else: diarrhea, heartburn, etc. BUT THIS WEEK IS THE WORST. I couldn't sleep one night due to the heartburn, I'm constantly nauseous and can't eat. Surprisingly, I've been constipated lately and had to take stool softeners. Yesterday (Saturday) I threw up 4 times!! Reading the other comments did help explain the other effects I also have been experiencing. I am EXTREMELY fatigued ALL the time, I'm already on anti-depressants, but this is actually making symptoms worse than before I was on Trulicity. I have constant headaches....."

• miz...
• Taken for 1 to 2 years
• June 7, 2019

For Type 2 Diabetes "I have been on Trulicity for about 13 months. At first, I experienced nausea and loss of appetite. I lost 13 pounds within about the first 6 weeks! I took nausea medicine to help me get through the nausea symptoms. But it did help my A1C drop from 9.3 to 6.6. After several months, my symptoms subsided and I seemed to be on an even keel. My appetite returned and I gained weight back. All of a sudden, for the last 5 weeks, I have been sick as a dog! The nausea has returned, I have indigestion and belching like never before, and stomach pain. I am miserable. I am constipated, I am fatigued, and my kidney specialist tells me the Trulicity is causing my problems. I took my last injection 2 days ago, and the rest of it is going in the trash!!! No more for me."

• Per...
• May 10, 2016

For Type 2 Diabetes "My doctor put me on this med, and it does work, but DAMN! The fatigue sometimes is almost unbearable. I am lucky that I didn't have any stomach issues, but the fatigue is really getting to me. I had to leave work in the afternoon just so I can lay down. I have my good days. The second day of the shot seems to be the worst. Not sure what I am going to do since it is really helping my A1C, but I still struggle with fatigue, which of course affects everything else, my sex drive is almost gone, and all I want to do is go to sleep."

• Nom...
• Taken for 6 months to 1 year
• December 15, 2015

For Type 2 Diabetes "Been on Trulicity for 6 months. No diarrhea, but super constipation. Major fatigue. I take 1000 mg Metformin (down from 2000) daily, plus the weekly 1.5 mg Trulicity shot. A1C at 5.9, which is great. I lost about 8 lbs. Frankly, I'm stopping it-bloating, cramping, and the constant fatigue is just not worth it. Time to get more active and eat right. It may be the hard way, but definitely the right way!"

• Tam...
• Taken for 1 to 6 months
• July 24, 2019

For Type 2 Diabetes "I have uncontrolled type 2 diabetes. I have taken Trulicity for 4 weeks because my Dr. said the symptoms would subside. I have stomach cramps, nausea all day, a headache, and just sorta malaise. I will not inject another shot. I gotta figure something else out."

• RHH...
• November 11, 2015

For Type 2 Diabetes "I have been on this medication for about a month now. Not as much nausea as when I was taking Bydurian, but I am exhausted, have no appetite, get sick if I eat anything fried (chicken), etc. Very anxious feeling all the time to the point of not being able to watch my grandchild, along with depression, which I think is due to feeling like crap on this medication. I have lost about ten pounds, but is it worth all this? Anyone else having these anxious feelings or malaise on this medication?"

• Scr...
• Taken for 1 to 6 months
• November 16, 2018

For Type 2 Diabetes "I had every side effect - some worse than others, but the worst of them was the appetite suppression. I ate virtually nothing for four weeks, went through ketosis, and finally into gluconeogenesis. Losing weight as a side effect is no bad thing, but not when it mimics a wasting disease. I have lost, on average, 1 lb in weight a day for the time I was on this drug. Constipation, stomach cramps, nausea, fatigue, and not wanting to eat a thing eventually drove me to seek an alternative. It did bring my blood sugar down, but the side effects have been horrendous. I'm pretty sure a carb-free diet would have had much the same effects."

• Jen...
• August 9, 2016

For Type 2 Diabetes "I have been taking Trulicity for about 5 months. The first month or two was really rough. I definitely had fatigue, nausea, and severe sour stomach, which are very embarrassing to have while you're at work. I have dropped about 35 pounds over the past few months, but that's because you never want to eat after you take the shot. I stayed on the .75 for the first 3 months, and for the last couple of months, I'm up to the 1.5, which increases the symptoms I have. My A1C was a 12.5, now it's a 5. Some days my sugar stays in the sixties and seventies, and I struggled to keep it up. Good luck, but is all this misery with good numbers?"

• Plh...
• Taken for 1 to 2 years
• January 16, 2017

For Type 2 Diabetes "I've been on Trulicity 1.5 for a few months now. I'm Type 1, so I also take Humalog and Tresiba. I have a love/hate relationship with Trulicity. It definitely helps with my sugars and weight loss. I don't have to take much insulin when I'm on it. However, I have random nausea, weakness, and fatigue. It seems lately that it's happening more often. It's hard for me to get things done during the day because of the side effects. So I'm trying to decide if it's worth staying on it."

• Rit...
• Taken for less than 1 month
• July 16, 2019

For Type 2 Diabetes "Day 1, after the first injection, I had bad diarrhea. Days 2-8, I felt worse than anything I have ever had. Severe nausea, bloating, horrible upper abdominal pain, fatigue, blurred vision, body aches. I lost 11 lbs in 8 days due to not being able to eat. I was taking everything I could for stomach relief (Pepto Bismol, Tums, Zantac, ginger root), but nothing helped at all. I swore I wouldn't take it again, but I gave it the benefit of the doubt because I don't want to go on insulin. I took it again after 10 days and only had slight diarrhea on day 2, so I have continued it. Occasionally, I still have a little nausea or slight fatigue/body ache, but I don't feel the urge to snack at all. I have not only kept off the 11 lbs but have lost 2 more. I'm only on my 3rd injection, so I'm not sure how it has affected my A1C yet."

• Whi...
• Taken for less than 1 month
• April 10, 2018

For Type 2 Diabetes "Terrible experience. Shortly after taking on a Sunday, I was extremely fatigued. Lost all appetite the rest of the day and Monday. Constant hiccups and burping, acid reflux was so bad by Tuesday night it woke me up coughing it up. Appetite started to reappear by Wednesday, so had a smaller normal meal in the evening. Early hours of the morning, projectile vomiting and diarrhea. After reading reviews here and seeing that thyroid cancer is a risk, contacted GP. Advised to discontinue. Felt unwell and like a zombie all week. It's very worrying that there are no long-term studies of this medication in humans. It causes cancer in mice and rats. Because it hasn't been tested, it's not known if it will cause cancer in humans. So we're all guinea pigs."

• Anonymous
• Taken for 1 to 6 months
• June 2, 2016

For Type 2 Diabetes "Give Trulicity at least 4 weeks. I, like many others, experienced upset stomach, nausea, and fatigue the first month, where symptoms decreased each week. The nausea was quick and unexpected, and I wanted to throw in the towel. I'm now on week 6 and feel fine most of the time. The fatigue is still there sometimes, but it's been manageable. This has been the best medicine for me by far. I am on the low dose 0.75 and also take metformin 500 mg twice daily. I find the best time to take my shot is at night before I go to bed, and I only take 1-500 mg of metformin the day after the shot, where the side effects were more active. I was on Kombiglyze SR that had 2000 mg of metformin. It did not work for me. My numbers are finally below 120 with Trulicity."

• Sdm...
• Taken for less than 1 month
• May 4, 2019

For Type 2 Diabetes "My A1c crept up to 7.4 after 4 years on Metformin, and the doctor suggested Trulicity in addition to staying on Metformin. After 6 straight days of Trulicity-induced nausea, cramping, diarrhea, fatigue, little appetite, leaving me weak, I honestly do not think I can handle a second week. Slight decrease in morning fasting, so I am just not sure what I’m going to do... Ugh."

• ont...
• Taken for 1 to 6 months
• June 14, 2016

For Type 2 Diabetes "Started 1st shot 9 weeks ago .75. No nausea, but not hungry at all. Still also taking Metformin 1000 and Glipizide 20 mg at the time. Into the 7th week, stopped the Glipizide, but still on the Metformin, started feeling the nausea and constipation. I also experience fatigue and headaches. My A1C is down from 7.6 to 6.5 now and have lost 10 lbs so far. Anyone else not get the side effects until the 2nd month? I feel like my experience is different from the majority. Going to continue unless it becomes unbearable."

• Nan...
• Taken for less than 1 month
• August 17, 2018

For Type 2 Diabetes "Second week on it, and I have never felt this bad before. Heart racing, water retention, shortness of breath, and the worst is the fatigue and no strength in my legs. Appetite has surely gone down since I have no urge to eat. Slight difference in blood sugar levels. Not sure if I can continue this medicine with all of the side effects."

• Meg...
• Taken for 1 to 6 months
• April 29, 2019

For Type 2 Diabetes "My age: 20. Time on Trulicity: 1 month at the lower dose. Weight lost (also started eating healthier): 10 lbs. Pros: - Lowers blood sugar numbers - Helps control cravings. Cons: - Slight nausea - Decreased appetite - Fatigue - Anxiety about having a low blood glucose reading - Low blood sugar (lowest was 47)."

• Anonymous
• Taken for 1 to 6 months
• October 13, 2016

For Type 2 Diabetes "I've been on it for about 3 months. I have a noticeable increase in fatigue, and my appetite is less, sometimes bordering on nausea (not necessarily a bad thing). I can't argue with the results, though. A1C dropped from 7.8 to 6.1 in just a few months."

• Swa...
• Taken for 2 to 5 years
• April 22, 2019

For Type 2 Diabetes "Trulicity helped for perhaps one year, but after that really provided no drop in sugar. It does make you feel fatigued and suppresses appetite, but probably not worth the costs. Metformin and Farxiga provide much better blood sugar control."

• DO...
• Taken for less than 1 month
• June 1, 2016

For Type 2 Diabetes "I got this shot during a doctor visit. Unsure if the dose was the .75 mg, but the 3 samples he gave me were of the 1.5 mg dose. Side effects began the following day: nausea, diarrhea, abdominal pain, decreased appetite, indigestion, and severe acid reflux. I also had body aches and fatigue. I dare say I felt depressed. I had just gotten over the stomach flu 3 weeks before, and it felt like I had come down with it again! Trulicity did lower my glucose levels, as did my weight (3 lbs. that week). Of course, it did! I could not eat, and whatever little food I ate, it came out in minutes! I DID NOT and WILL NOT inject myself with this again. I'm sorry I agreed to the shot. One of the worst weeks of my life!"

• The...
• Taken for 1 to 6 months
• June 15, 2016

For Type 2 Diabetes "I can agree that the fatigue is noticeable. My biggest shock was the diarrhea. I hadn't planned for it, and luckily I was at home when it hit the first time. It was akin to the flushing out one gets when they are preparing for a colonoscopy. I was noticing my abdomen growling. I am a bit lactose intolerant, and this was similar to if I had cereal with milk. Then suddenly I had THE URGE!!!! I was wearing shorts, and just made it to the bathroom and was able to jump into the shower as I knew there was no way I'd be able to drop trou and hit the toilet when it hit. It was as if a dam had opened. I just turned on the water and slowly removed my clothes as wave after wave struck. Luckily, that first time was the worst. Now I'm prepared."

• Stu...
• Taken for less than 1 month
• May 22, 2018

For Type 2 Diabetes "I started Trulicity a week and a half ago. Side effects were a few minor headaches, one migraine-which may not be related as I've had them in the past. Heartburn on the second day. One low blood sugar event 24 hours after the shot. Some burping. Feeling of nausea which only lasts for about a minute but could be a few times a day. Less appetite-lost 3 lbs. General malaise after eating for an hour or so. BUT it is getting better, symptoms reducing. Blood sugar readings excellent. 87 after work. 130 after meals. (sensible meals) 90-100 in the AM. Pretty impressed."

• Ang...
• March 12, 2022

For Cardiovascular Risk Reduction "I have been on Trulicity for about 3 months. The worst 3 months of my life. After having severe stomach pains, I was referred to a surgeon to have an endoscopy and colonoscopy after a CT scan showed acute pancreatitis and numerous other stomach issues. The surgeon only told me I needed to review my medications with my doctor, never once telling me of the complications with Trulicity! I experienced every side effect from blurred vision to severe cramping, abdominal pain, racing heartbeat, fatigue, and constant diarrhea. This drug needs to be removed. I have been in so much indescribable pain that anxiety and depression kicked in, not knowing what was wrong. I am waiting for it to leave my body. This has been a complete nightmare."

• Nan...
• Taken for less than 1 month
• January 3, 2021

For Type 2 Diabetes "I started Trulicity 3 weeks ago. Have had only fatigue as side effects, but my numbers are still way too high. Even when I watch my carbs constantly, my early morning numbers are around 185. Tired of no improvement!! I inject in the abdomen, should I try thigh? I always eat a little beforehand. Is this why numbers stay high?"

• Jim...
• Taken for 1 to 2 years
• December 2, 2018

For Type 2 Diabetes "Serious watery stool, loss of appetite, lower back and leg pains, low energy, etc. It did help to lower A1c with other meds, but am stopping it due to side effects. My doc will just have to help me find some other way to control blood sugar levels. Am also concerned about possible other organ damage due to the use of this product."