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Doxepin User Reviews & Ratings (Page 2)

Brand names: Adapin Silenor

Doxepin has an average rating of 6.1 out of 10 from a total of 422 reviews on Drugs.com. 52% of reviewers reported a positive experience, while 35% reported a negative experience.

Reviews for Doxepin

  • Timaaay
  • March 6, 2017

For Insomnia "I had suffered an unspeakable event a few months agoIf you think of your worst thought, this was worse. I've never been depressed or on any psyc meds in my life. I went about 6 weeks sleeping, perhaps 2 hours per night. I awakened with nightmares of the event. I tried Ambien, which made me fall asleep, but I'd only get 3 hours of sleep on a good night, usually less, awakened by nightmares. The doc gIve me Doxepin 100mg capsules. I slept 16 hours straight! I now take 100mg about 30 minutes before bed and sleep 6-8 hours and most importantly, I don't have nightmares. I don't remember any dreams and I don't have the "Hangover" Ambien gave me. This drug has been a miracle for me literally"

10 / 10
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  • Anonymous
  • May 23, 2017

For Depression "I was diagnosed with major depression at 42. I also suffered from crippling anxiety and chronic insomnia. I was prescribed Doxepin after trying other antidepressants which had shocking side effects and made my symptoms worse. Doxepin pulled me out of the abyss and gave me my life back. It literally saved my life and I thank god every day for this amazing drug. I have been taking it for 23 years and it have had no side effects from prolonged use of this medication."

10 / 10
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  • Anon
  • Taken for less than 1 month
  • November 2, 2019

For Anxiety "Been on doxepin 10mg for insomnia and anxiety attacks. In only three days it has changed my quality of life for the better. I take it at 9pm, and I’m asleep by 10:30 or 11pm the latest. I sleep all night. I do feel a little groggy in the morning but it goes away after an hour of moving around. It keeps me centered and functional throughout the day. No anxiety, or panic. It has relieved my palpitations too. A bit of a dry mouth but my pharmacist suggested I drink water or suck on ice cubes. It relieves the dry mouth. I was put on sertraline 50mg and buspirone before this and that combo totally messed me up. They caused me mild serotonin syndrome (rapid heart rate and high blood pressure). I’m so glad my doctor put me on doxepin. It has helped so much! I will not touch sertraline or buspirone ever again."

9 / 10
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Frequently asked questions

  • Gotri...
  • Taken for 6 months to 1 year
  • March 20, 2016

For Anxiety "I was experiencing very bad anxiety and was having panic attacks nearly everyday. I also had issues sleeping, I couldn't sleep more than 2 hours at a time. My doctor put me on 75mg once daily at bedtime. I feel like my old self. I am sleeping very well at night and I haven't had a panic attack in 8 months. Doxepin gave me my life back."

10 / 10
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92 Report
  • blh
  • May 25, 2017

Silenor (doxepin) for Insomnia "I was prescribed 3 mg tablets for insomnia. The first night I took one about 45 minutes before bedtime and did not find it helped me sleep at all. However, I was extremely groggy the next morning and ended up back in bed by shortly after lunch, sleeping for almost 2 hours. I tried it two more times, taking it earlier each time, but the effect was the same: it takes too long to work and leaves me groggy and unable to function the next day. I will not be taking it any more."

1 / 10
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  • Urban...
  • Taken for less than 1 month
  • March 29, 2015

Silenor (doxepin) for Insomnia "This stuff really did the job. It knocked me on my booty and I am used to taking medications that make you sleepy. This kept me sleeping all night long after about 3 weeks of falling asleep and not being able to stay asleep for more than an hour or two. My prescription is for 25 mg and I only took a half. Just to let you know, You may want to try it when you do not have to work the next day. I am not sure if I could have gotten up in time for work this morning if I had to. I do all medications like this slowly and I never start out at my prescribed dosage. I always start out a lot lower dosage and go up from there if I need to. I do feel a bit of anxiety today. Not sure if it's the medication, or? I am wide AWAKE now. A bit strange."

8 / 10
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  • M H
  • Taken for 6 months to 1 year
  • September 17, 2017

Silenor (doxepin) for Insomnia "Use to take Ambien but side effect were starting to drive me nuts. Nightmares, almost depressed when waking up. Silenor really saved me. Incredible feeling, like normal sleep. No side effects at all in my case. I'm surprised it's not more promoted."

10 / 10
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  • Snidely...
  • April 7, 2017

Silenor (doxepin) for Insomnia "Silenor's active ingredient is doxepin. A 90 day supply of doxepin (it will be in liquid form to be mixed with water) costs $12 . I gave this information to my doctor and he prescribed the doxepin. My insurance company is not involved and this has saved me a substantial amount of money. I've been using it for about four years and am very happy with the results."

9 / 10
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  • jimig
  • October 30, 2016

Silenor (doxepin) for Insomnia "Great product. I never had a problem falling asleep before, I can and always could fall asleep in 2 or 3 minutes. My problem was during the night when I would wake up at 2am and be up for the day. With Silenor I still wake up on occasion but I go right back to sleep. I have been taking it for months now, still works great. Not groggy the next day. If your problem is getting to sleep this might not be right for you. If your problem is staying asleep or falling back to sleep after waking up during the night then Silenor will be a big help."

10 / 10
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  • fayfa...
  • Taken for 10 years or more
  • October 13, 2013

For Depression "I've been taking Doxepin & Xanax and Zoloft for over 20 years, for depression/anxiety/panic attacks and insomnia. All three medicines work but only one has lasted, Doxepin. The other two I had no choice but to stop taking. I ended up with serious breathing problems. Zoloft several years after taking, subsided and then worse years later and Xanax after about a decade or so. Doxepin has done very well with all my conditions throughout the years with no serious problems. IT WORKS. "

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  • fayfa...
  • November 20, 2015

Sinequan (doxepin) for Anxiety "If you're not able to take or no longer able to take SSRI'S, SNRI'S & Benz's this is a drug to consider. I've taken it off an on for decades. It helps tremendously in maintaining a normalcy n excellent for someone deprived of sleep. Takes time,but once adjusted it will become less of problem.Although it will continue to help for a good night's sleep. It's best to take this medication later in afternoon, until you do adjust. God Bless,"

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  • Garyl...
  • Taken for 10 years or more
  • January 29, 2016

For Urticaria "After suffering with chronic idiopathic urticaria for 20 years, a new Dr. put me on this old medicine which has a VERY strong antihistamine effect. It stopped the hives dead in their tracks, and now, being on the medication for 22 years, I have yet to ever develop another hive. This medication is a GREAT. I've never used anything even remotely effective as this medication to prevent hives (even steroids wouldn't stop them!). Doctors gave up on me and could never figure what the cause was/is. Doesn't matter now as they completely under control."

10 / 10
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  • DKT
  • May 17, 2015

For Anxiety "Been on many SSRIs, a few SNRIs, and some of the TCAs. I took Tofranil (imipramine) for about 6 months on a starting dose of 25 mg and eventually increased slowly to 125mg. Over the course of those 6 months, my anxiety was under control for the most part, but I developed myoclonus and had to stop taking the drug. I switched to Sinequan (doxepin) 25 mg, increased to 75 mg, divided into 25mg three times a day and have done well, without any side effects besides mild fatigue. No bad thoughts, lingering anxiety or panic attacks. Very successful drug (doxepin) for me so far. Been about 3 months now."

9 / 10
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  • johns
  • Taken for 1 to 6 months
  • March 24, 2013

Silenor (doxepin) for Insomnia "This medicine was just like taking Benadryl, only more expensive. An hour to two hours after taking Silenor, I still couldn't fall asleep...not even the slightest bit tired. Once I had fallen asleep, I would wake up 2-4 hours later and be wide awake for the rest of the night. "

2 / 10
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  • jjones
  • October 10, 2010

Silenor (doxepin) for Insomnia "I have used all known sleepers and other off label medicines for sleepers and I have taken Silenor 6 mg for 3 nights. It is amazing. I fall asleep with no problems and stay asleep for 7-8 hours. No hang over or other side effects. I had been taking Remeron 60mg for sleep, as it was the best of all I had tried. I thought the Remeron was doing an okay job until I tried the Silenor. I am thrilled and feel more rested then I have in years."

10 / 10
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  • JB1950
  • Taken for less than 1 month
  • February 1, 2017

For Insomnia "I retired over 3 yrs. ago and almost immediately my schedule began to change, ending up in a situation in which I couldn't fall asleep sometimes until as late 5 or 6 am, and not get up until around noon! Yesterday my lung doc, who also does sleep studies, suggested doxepin. I had already had a bad experience with it many years ago - 10 mg. It put me to sleep alright, but I felt like a frigging zombie the next day .He told me that was too strong a dose and recommended half of that. He also told me that most insurance companies won't pay for it in any dose except the generic 10 mg. capsule. Not the 3mg. tablet or the liquid. So, I half the caps nightly in water. Slept fine;no hangover. Retired 11:30 & up @ 8.Hope tonight's same. Dose is key!"

8 / 10
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  • Sarah...
  • Taken for 1 to 6 months
  • July 16, 2016

For Depression "My sister took doxipen and it had a horrible reaction... anxiety, changed her personality, sleeplesness... she told her Doctor so he increased the dose... she hadn't slept in 3 days so she took xanex to sleep... she died that night... 6/26/2016... she was 28 years old."

1 / 10
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  • Insom...
  • Taken for 1 to 6 months
  • February 27, 2013

For Depression "I've been diagnosed with chronic insomnia and general anxiety for 9 years. I also suffer from depression, but refuse to be medicated directly for it (specifically SSRI's) after dealing with Paxil and the horrible withdrawal I experienced 8 years ago. So recently I was prescribed 30mg Doxepin in addition to my Zolpidem (Ambien) for my insomnia. My insomnia has slightly improved, but more pronounced has been the reduction in both occurrence and severity of my anxiety (within the first week) and depression (after about 3-4 weeks). It's been about 6 weeks since I started the doxepin and haven't noticed any negative side effects besides some dry mouth/eyes, which is far outweighed by the benefits I've received."

9 / 10
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  • 456po...
  • June 19, 2013

For Insomnia "I have been taking 25 mg of Doxepin for 17 years, I always could fall asleep, but if I woke up during the night, I couldn't go back to sleep for hours. Doxepin was like a miracle to me, I was never groggy the next morning and it didn't make me sleepy and groggy right after taking it. It just lets me go right back to sleep if I get up to use the bathroom. It still works after all these years, not as well though. I have weaned myself off of it, but I start having hot flashes off and on all day...so I start taking it again. And after being off of it for a few days the sleep problems seem to be back...so I may be on this for the rest of my life. I have recommended this to several friends and it has also helped them."

10 / 10
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  • fayfa...
  • Taken for 10 years or more
  • September 20, 2015

Sinequan (doxepin) for Depression "It works tremendously well on Insomnia and really does help on maintaining a normalcy in everyday life. Sleeping a lot at first, which in my case was a good thing. It's not the best for uplifting depression and doesn't help in taking away anxiety or panic attacks. The side affects for me was being easily bothered & hostal/angry. Will pass if you continue taking as directed,but each time you stop n then start again the experience starts over. But keep in mind,side affects vary and its different for each of Us. What works for one might not work for another. I've been taking Sinequan/Doxepin for over two decades."

9 / 10
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  • jmmh
  • May 23, 2013

For Insomnia "This medication knocked me out every night and so it was great to catch up on years of sleep debt. Overall, a very positive experience. However, like other users, I slowly gained 10-20 pounds over the course of taking doxepin. I stopped taking it in the last couple of months, and suddenly, my appetite significantly decreased and weight just started dropping off. I had no idea that the medication caused this increased appetite/weight gain. Honestly I thought I was just growing older and my metabolism was changing. I'm glad I took this medication for insomnia, and also that the side effect of weight gain faded away as soon as I stopped taking it. Overall, the value of the sleep I gained far outweighed the con of the weight I gained."

10 / 10
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  • Anonymous
  • Taken for less than 1 month
  • January 25, 2017

For Anxiety "I started doxepin last night and I have insomnia and wake up several times during the night. I slept from 6:30pm til 7:30am, but still a little tired today, but I didn't wake up once. So, so far so good. I think I'm going to be very pleased with this drug. It also helped a lot with my anxiety as well. I've had zero side effects so far and hopefully won't have any. Good luck to everyone that takes it cuz for me after trying several meds, this seems to be the best one so far and without weight gain too. Most insomnia medication causes weight gain from the research I've done and this one doesn't thank god because I've just lost 110lbs and do not want to put any weight on now that I'm at my perfect weight size for my height. I hope this helps."

10 / 10
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  • Mike
  • Taken for 1 to 6 months
  • March 29, 2023

For Insomnia "I’ve been using doxepin for a while now and I find it very useful for helping with sleep. I use 10 mg every night and I usually get 7-8 hours. The first week or so, yes I felt pretty hung over and sleepy all day but that faded as I stuck with it. Does it truly knock me out? I’m not sure. I seem to fall back asleep upon awakening much easier now. I also believe doxepin improves my mood and anxiety overall which makes sleep easier all on its own. I haven’t gained weight… In fact, it’s the opposite for me. I have way more energy now due to more sleep so I’ve been exercising and dieting better than when I was getting bad sleep. I have tried 3 mg and 6 mg (I used a compound pharmacy due to those dose sizes not being covered by insurance for some reason) but I don’t find them more useful than 10mg. I have also used trazodone in the past and I feel that doxepin works better and doesn’t cause a stuffy nose like trazodone does. I say give it a try!"

8 / 10
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  • Jabber...
  • August 30, 2013

For Insomnia "I've been using doxepin for about 2 years for insomnia. I used to wake every night after 2-3 hours of sleep and then was unable to get back to sleep for 1-2 hours. This has helped tremendously. I now sleep through the night, dream and feel better through the day. If I do wake, I am able to roll over and get back to sleep quickly. I take it just prior to bed, and get about 7 solid hours of sleep. I experience some dry mouth in the morning, but nothing severe, and it can be a bit difficult to get going in the morning. Overall, I'm much better than before."

9 / 10
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  • aquab...
  • August 10, 2014

For Insomnia "I started this medication about 10 days ago. Doxepin, 10mg, has been working more days than not. Like most medicines, the first few days it worked like a charm. I took it and I slept about 5.5 hours straight. Sometimes can go back to sleep for another 1/2 an hour. I do feel a little help in the anxiety category. Not a lot but it does help a bit. The bad thing about this medicine is that you feel very sedated throughout the day. You know you slept because of the vivid dreams and you don't wake up the whole night. Nevertheless, you feel extremely tired the whole day. I wish I didn't have to take medicines. But I rather be feeling sleepy and knowing that I slept as opposed to feeling sleepy due to no sleep."

7 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.