Dalfampridine for Multiple Sclerosis User Reviews (Page 3)

• Oct...
• Taken for 5 to 10 years
• November 28, 2019

Dalfampridine "I have been on 4-amino pyridine for nine years. It is the very old generic version before the original version and the new generic. It says on the Ampyra literature to not take Ampyra if you are taking 4AP. 4AP was approved years ago for spinal cord injuries and used off-label for MS. The company went back to the FDA for approval for MS and got a new patent. I get 4AP compounded for $104 for 180 pills for a 3-month supply. It has continued to help tremendously. Check out 4AP!"

• Mav...
• Taken for 1 to 2 years
• February 11, 2019

Dalfampridine "I'm 53 and started on Ampyra 20 months ago, and about 4 months ago I switched to the generic (Ascent) - seems to be no difference except that the time release may be a little different. As far as performance, the benefits peak for me at hour 8. With the medicine, using a treadmill takes me 10 minutes, and without the same incline and distance, it is 12 minutes - starting out at the same but slowing faster without. Side effects are minimal, but I do skip when I can as this lessens the likelihood of serious side effects like seizures - I take 12 a week, and I have a full-time job. Also, beyond the medication, rest, stress reduction, and diet - try the Wahls - improve symptoms - Best always - hope this helps."

• Duc...
• Taken for 10 years or more
• March 15, 2020

Dalfampridine "I started with RRMS and have progressed to SPMS. When I started to slowly get worse, I was introduced to Ampyra and noticed a difference, not a lot, but it still helped. I’ve been on Ampyra for 17 years and still have been losing mobility to the point of having to use a wheelchair for most of the day. So I decided to ask my doctor to slowly take me off the Ampyra because I didn’t think it was working anymore. I noticed the very first day I was having adverse effects. On the second day, I couldn’t stand up without help. I decided that night to go back on the full dose of my Ampyra and the very next morning I was much better and able to move like I used to. I still don’t move well but much better with the full dose than without it. Ampyra is a necessity for me. I would be wheelchair-bound without it."

• Jar...
• Taken for 2 to 5 years
• May 11, 2017

Dalfampridine "This is a missing side effect that should've been noted in the prescription information! For the first two years this medication came out, I continued to use it along with my disease management drug. I was taking Tecfidera. These two medications combined drastically slow down your lower intestinal. Ampyra lists constipation as a minor, less common side effect. After some research with my doctor, he researched the medications in medical journals and the chemical compounds, and he thought the two should not be taken together for this particular reason."

• Mo ...
• Taken for 6 months to 1 year
• October 31, 2017

Dalfampridine "It's been 6 months since I've started taking Ampyra. It is still a miracle drug, and I would recommend it to anyone with MS. The only side effect I've had was slight back pain. That side effect only lasted about 2 weeks. I've noticed a difference in my walking immediately, and I still stand by this med. I do notice if I forget to take a pill, then I have to wait to get back on schedule. That's the only complaint."

• Dee...
• Taken for less than 1 month
• January 20, 2022

Dalfampridine "I was diagnosed with MS in 2018. Fatigue, balance, and heavy legs were my major issues. Started Ampyra 2 weeks ago, and it's AMAZING the difference! I have more energy, my balance and walking distance have improved significantly. I experienced dizziness the first week, but it went away in week 2. Highly recommended!!"

• gre...
• Taken for 5 to 10 years
• December 7, 2017

Dalfampridine "I have been taking Ampyra for 5 or 6 years. It has greatly improved my walking and my cognitive ability. It helps me to continue to be a productive person. I would be afraid of a generic. It is a serious medication. I feel I would be taking a chance on my health and abilities. I have talked with my doctor, and he agrees."

• Mar...
• June 15, 2019

Dalfampridine "I started on Ampyra 7 weeks ago and have not noticed much difference. I am 59 with RRMS (relapsing-remitting MS). It is hard to rate because I am not sure. I am leery about stopping because I had high hopes for this drug. I may stop for a couple of weeks, then try it again. It seems like it helps many, so I am hoping this will be me the second go-around. Peace and happiness."

• Lea...
• Taken for 1 to 6 months
• September 9, 2021

Dalfampridine "I've had 'mild' MS (only 2 'episodes') for 40 years, with mild symptoms despite my brain looking like Swiss cheese and lesions continuing down my spinal cord. Four years ago, I started losing power. I could walk around the house, but I was slow and wobbly. For safety, I used a rollator whenever I left the house. My right arm and leg were much diminished. I've been on dalfampridine 10 mg, 2X per day, for 5 weeks now and becoming disillusioned. I had no side effects, but also, really no improvement. I suppose it's possible that my condition is worsening faster than the Ampyra can improve me, or maybe I'm just one of the unlucky ones for whom it will not work."

• Vyn...
• Taken for less than 1 month
• November 10, 2016

Dalfampridine "I am very disappointed. I had tried Ampyra about 3 years ago and found no effects at all. At the urging of my neurologist, I tried again this year. For symptoms, I am taking Provigil & Baclofen. I take Copaxone as a disease-modifying agent. Previous to restarting Ampyra, I was doing 1/4 mile on a treadmill 3 times per day, plus one mile on the elliptical at night. My legs felt very heavy on the first day of Ampyra. I might have done just one rep on the treadmill. I thought possibly that my body was adjusting to the medicine, so I gave it about one week. I found it difficult to do my daily treadmill. Legs also were throbbing slightly at the end of the day. This medicine had a negative effect. I am out a $300 copay."

• Deb...
• Taken for 1 to 2 years
• December 6, 2019

"I was on name-brand Ampyra for 6 years and loved it. I could walk, dance, and do stairs. When a generic became available, my insurance would no longer cover name-brand, even when my physician wrote it a 'dispense as written.' Without insurance, it would cost $7,000 a month. So I agreed to the generic. I have tried the generic from 3 different manufacturers. The Mylan version (made in the same plant as the name brand) is essentially the same as the name brand. The Accord version works as well but only lasts 2/3 as long as the name brand. The Ascend version made overseas is almost worthless. I am not in a wheelchair (yet), but I am back to using a cane and walker. I can no longer dance or use stairs. The pharmacy approved by insurance will not change from whom they get their generic (they use the least expensive one). I now know the monetary value of walking is $7,000 a month. This is more than twice what I make working a full-time job that I'm not sure I'll be able to do if I can't walk."

• Rea...
• Taken for 2 to 5 years
• September 8, 2022

"I have been taking dalfampridine for 4 years. This medication has improved my ability to walk to where I rarely use my cane. I was on the fast track to a walker, but after about a month of this medication, I noticed that I didn't have to use my cane for every step. I have to watch if I miss a dose, for it does affect my balance and back pain."

• Sup...
• Taken for less than 1 month
• June 13, 2022

Dalfampridine "June 2022, after breaking my leg, then Covid so no physio. I had drop foot, and walking became hard. I was initially put on Fampyra (France) about 5 years ago but took myself off it as I didn’t need it as I was walking well anyway. After my fractured leg and realizing I was losing the ability to walk and flex my knee, I thought now maybe the time to try again. Contacted my consultant, and he prescribed it for me. Wow, I noticed a difference after 3 hours! I've been on it now 10 days, 10 mg x2 daily, and my drop foot seems to be easing, and my walking action seems more normal. It is hot at the moment, which of course won’t help, but I can really see the difference after my dose seems to wear off and I am due to take the next dose in a couple of hours. Easy to use, no side effects. I feel hopeful again and can see possibilities after only 10 days. My physio can see an improvement the minute I walk towards her, the next thing is to get in the pool, with care of course."

• RAK...
• Taken for 1 to 6 months
• October 13, 2021

"I have SPMS. After 2 months free trial of Ampyra, I have switched to a generic version due to insurance coverage. I find both work equally as well. The main thing I notice is an improvement in fatigue. I have foot drop and significant spasticity in torso and legs, especially the left one. I don’t know if my walking is necessarily better, but fatigue used to really make my walking much, much worse as the day went on. Since taking this, I feel my walking ability maintains a more steady level throughout the day. This drug has greatly improved the spasticity in my torso, which was becoming one of my most uncomfortable symptoms. These improvements have been enough for me to consider the drug very worthwhile. No side effects at all. Definitely worth a try."

• RUT...
• Taken for 1 to 6 months
• June 11, 2022

Dalfampridine "I have had MS since 1979 and have been on an injectable DMT since 2004. Before that, I took massive doses of Imuran. My neurologist started me on Ampyra to help the slight stumbling that had started bothering me. In 5 weeks, I asked him if I could stop. The very subtle good it did to start, slowly has been making my walking and balance worse than it has been in the decades I have had MS. I'm hoping PT may help some, but I don't think I have felt this disheartened over the course of the last 43 years."

• And...
• Taken for 5 to 10 years
• September 26, 2020

"I wanted to know if other people were experiencing the same as me. And then I found these reviews, with one person saying that the Mylan version is like the original, and the Ascend version is garbage. I looked at what Kroger provided me and was not surprised to see that they gave me the Ascend version. If I'm unable to convince Kroger to provide me with a different manufacturer, I will return to the compounded version, although it's almost twice as expensive."

• cic...
• July 15, 2014

Dalfampridine "I love Ampyra. I have been taking Ampyra for 3 months. I feel much stronger. I'm back going to the gym every morning for 2 hours."

• Anonymous
• April 14, 2011

Dalfampridine "I've taken Ampyra for seven months. I went from wheelchair to walker to cane in two months. Now I only use the cane when going out. It has done wonderful things for me."

• mil...
• Taken for 1 to 2 years
• October 3, 2013

Dalfampridine "I feel that my legs are a bit stronger on this medication. It's great to feel a bit more confident when walking."

• Liz...
• Taken for 2 to 5 years
• December 26, 2014

Dalfampridine "My experience with Ampyra is really great. I love the medicine because even when I don't want to walk, I walk fast."

• Anonymous
• April 1, 2012

Dalfampridine "Caused constipation, but the medicine has definitely increased the quality of life. I have been on it for 6 months and it is as good today as that first couple weeks."

• car...
• May 20, 2011

Dalfampridine "I love Ampyra. It's such a shame it is expensive to get. I can now make it to the bathroom in time. HUGE improvement with that alone. But I can walk upstairs without lifting my legs with my hands."

• Anonymous
• June 14, 2012

Dalfampridine "This medicine leaves me feeling exceptionally dizzy and off balance. After seven months, it is doing nothing to help me walk."

• car...
• Taken for 1 to 2 years
• February 26, 2015

Dalfampridine "I've been on Ampyra almost a year and still able to walk a short distance without assistance. Maybe 3 steps, but it's better than not moving."

• lys...
• July 20, 2010

Dalfampridine "I've only been taking Ampyra for 2 months, but all I have noticed is heavier legs and falling much more. I use my walker more than my cane."