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Periactin and Drowsiness: What Users Say

Drowsiness: mentioned by 14 users (21.5%)

Based on user experiences from 65 Periactin reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

drowsiness 21.5%
weight gain 16.9%
increased appetite 13.8%
sleepy 12.3%
mood swings 4.6%
tiredness 4.6%

Reviews for Periactin

Commonly mentioned side effects
  • A m...
  • June 2, 2017

For Anorexia "This is simply something magical! I've been underweight naturally since childhood, always hearing 'you should eat more,' although I really had a good appetite. I can't even wear the clothes I want as I feel so bad to see my skinny legs and hands, etc. I sat at night and thought about what else I could try to put on weight, as protein milkshakes and squats didn't work for me. I googled Periactin, ordered online from Weldricks (UK), and I want to cry and scream to the world how happy I am! Using it for two weeks, 1 tablet before bedtime - gained 4kgs, never had this weight before! I eat around 3000-4000 kcals a day. It also makes me feel really sleepy and tired, but it means nothing when you see those amazing numbers on the scales."

10 / 10
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144 Report
  • JoJ...
  • June 29, 2014

For Anorexia "All my life, I have struggled to gain or maintain my weight. There are periods when I have no appetite. I can go for days without eating and not feel hungry. This medication has been a godsend. At first, the drowsiness was almost debilitating. After reaching my desired weight, I found that reducing the dose to 1/4 tablet per day maintained it without the side effects. My son suffers from the same issue, and he is now taking it too. I highly recommend it to anyone wanting to gain weight."

10 / 10
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175 Report
  • CiC...
  • Taken for 1 to 2 years
  • November 2, 2018

For Anorexia "I've had problems with my weight all my life due to depression and anxiety. I would literally go days without eating. I started taking Periactin about a year ago and it worked great! I ate multiple times throughout the day. I stopped and lost all of the weight I gained. I started taking them again 2 weeks ago and I've gained over 10 pounds already. I get sleepy but it's tolerable."

10 / 10
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78 Report

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  • Mel...
  • January 25, 2015

For Anorexia "I've always been very thin, and I disliked the way I looked in the mirror for years. Then 3 years ago, my mom introduced me to this medicine, it worked wonders for my body. It stimulated my appetite, made me sleepy, which was good since I had problems sleeping, and this medicine changed the way I looked. I was curvy and attractive. I took one pill every day or sometimes every other day, and I moved from a size 0 to a beautiful size 6, and I was very happy with myself. The sad thing is I'm in China for one year doing my postgraduate degree, and the stresses of being here have pulled my weight down to 8 kgs less than where it was when I first came here."

10 / 10
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112 Report
  • Kha...
  • October 16, 2015

For Anorexia "Was very underweight for my age. Started taking these to help with it and be healthier. I was 102, and I went to 158 in about 2 months. It's been almost a year, and I chose to lose some of the weight, and I'm down 8 lbs, but weight still here. I have a lot of curves now. Side effects are sleepiness, but I started cutting my pills in half, and that helped a lot. I would take half a pill every 2 hours, taking 2 pills a day, and then cut back to one whole pill a day after weight started coming on fast."

10 / 10
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96 Report

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  • Thi...
  • Taken for less than 1 month
  • August 25, 2016

For Anorexia "I have been wanting to gain weight for over ten years. I have a really hard time eating. It's like a chore for me to force myself to eat, and I get full really quickly. Everyone tells me I'm too thin all the time, and mass shakes make me want to puke because they're too sweet and thick. So I've been underweight most of my life. I searched the Internet, and about two weeks ago, I found reviews for Periactin and got really excited to try it. So I got it prescribed right away and have been on it for a week now. I've gained 10 lbs already! This is a miracle! I felt a tiny bit sleepy the first two days, but I've always felt tired from lack of nutrition, so it wasn't much of a difference. I'm so excited to keep gaining!"

10 / 10
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74 Report
  • Poo...
  • Taken for 6 months to 1 year
  • April 5, 2014

For Migraine "My neurologist put me on 4x4 mg Periactin at night as a preventative for chronic migraine. I was aware of the weight gain possibility and started running and yoga. I slowly gained 5 kg in 5 months. Upon noticing this, I tried even harder. With time and dedication, I was able to exercise and eat my way back down to my normal skinny weight. When I'm hit with a carb craving (which is pretty often), I eat 30 mg of a healthy carb (such as a 2-inch chunk of carrot). It satisfies perfectly as long as you haven't consumed a protein in the last 2 hours. Do not turn to fatty carbs. The drowsiness also wore off in the first week. I am the healthiest and best version of myself, thanks to migraines. Choose not to be a victim. I now run charity marathons and have kept my career."

7 / 10
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68 Report
  • scu...
  • September 27, 2015

For Migraine "Cluster migraines made my life a misery. New doctor, new approach, and with Periactin of 5 x 4 mg at night has changed my life. Yes, be careful with the weight gain, and the sleepiness abated after two weeks. Some strange dreams as well."

9 / 10
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29 Report
  • Num...
  • November 20, 2011

For Allergic Reactions "Started this medicine 2 days ago. Slept for 14 hours straight. Hunger just kicked in, and I ate a huge sandwich and drink, and I'm still hungry. Changed dose to 1/2 of 4 mgs and got up this morning normally. I intend to build up slowly because of the sleepiness side effects. I intend to stay on this due to my fast metabolism and stress to get back to normal. I think it is working!"

9 / 10
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32 Report
  • Mad...
  • Taken for 1 to 6 months
  • June 12, 2024

For Anorexia "Being small my whole life, I thought I’d be small forever. I tried everything I could to gain weight and nothing worked. Until I decided to try medication, and that’s why I tried Periactin. Before starting Periactin, I weighed 104, and in a month and a half (no joke), I gained twenty pounds! Forever grateful for this medicine. The first week leaves you drowsy, and once the medicine regulates you're fine, it just gives you this constant placebo, you’re hungry, and boy does it make you eat."

10 / 10
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2 Report
  • Hiv...
  • Taken for less than 1 month
  • April 16, 2014

For Urticaria "While taking this stuff, I began to have an insatiable appetite. My mouth is almost always dry, and my ears will have a screeching noise. It puts me to sleep within 20 minutes and is hard to shake off in the mornings, much worse than Benadryl. It is playing an effective role in controlling the chronic hives I have had for close to a year. Although I don't enjoy any of the side effects, I do thoroughly enjoy not having hives all the time! I have a much better quality of life since I've begun this new prescription!"

8 / 10
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17 Report
  • Num...
  • December 4, 2011

For Anorexia "On Periactin now for three weeks. I've gained 6 lbs so far. Still making me drowsy. Will keep you updated."

10 / 10
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79 Report
  • Anonymous
  • August 22, 2020

For Anorexia "Every time I take it, it makes me hungry, and every time after a meal, it makes me sleepy."

8 / 10
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24 Report
  • Anonymous
  • October 11, 2009

For Allergic Reactions "I used Periactin for approximately 6 months to relieve an allergic reaction, and it worked extremely well. It did make me drowsy, though, therefore, I halved the dose I was recommended."

9 / 10
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20 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.