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Wellbutrin XL User Reviews & Ratings (Page 2)

Wellbutrin XL has an average rating of 7.4 out of 10 from a total of 438 reviews on Drugs.com. 67% of reviewers reported a positive experience, while 15% reported a negative experience.

Reviews for Wellbutrin XL

  • dani
  • Taken for 6 months to 1 year
  • November 21, 2023

For Major Depressive Disorder "I was depressed for 9 years with sudden onset at 17 that was so severe I got it while eating only healthy with lots of protein and going to the gym 5-6 times a week while having the time of my life socially. Immediately, I knew it's not environmental so I started seeing psychiatrists. I was started on Zoloft, which helped partially but stopped working (made me bipolar-like). After Zoloft, I tried a lot of garbage like paroxetine, escitalopram, fluvoxetine, lamotrigine, seroquel, abilify, modafinil, duloxetine (even tried ordering Parnate from the black market but it got seized). The list goes on. Eventually, I begged my psychiatrist for bupropion and lo and behold, 1 week in, cured. From daily suicidal thoughts for 9 years to NONE. And no sexual side effects like others, only 150mg does it for me, no side effects at all. On 300mg, I get irritable and get amphetamine-like side effects (jaw grinding), so more does not equal better. This is my first review and hopefully my last (at least for depression regimen)."

10 / 10
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  • Optim...
  • February 17, 2016

For Depression "I have anxiety and depression. I tried SSRIs and they just masked the depression and caused sexual side effects. Wellbutrin XL helped me feel much better and I didn't have negative sexual side effects. Best sex I've ever had on Wellbutrin XL. Now with the future I think about, feel optimistic about and am planning for it . I don't have anxiety like I had. I am more philosophical, "Tomorrow will be a better day. I'm motivated to accomplish things. I wish I had found this med years ago."

10 / 10
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  • Inspi...
  • June 22, 2018

For Depression "After being on several medications and therapy for over a year and experiencing numerous suicidal thoughts, I had given up on life. I read reviews on here of people saying “be patient and your life will change.” My life never changed and I was stuck in the same lifeless routine everyday. I now take 187.5mg of Effexor XR with 150 Wellbutrin XR, and trust me it took months for things to improve but everything changed. Suddenly life didn’t seem so awful. I began making goals for myself, and I wanted to get up and be active instead of sleeping my depression away. I do get slightly depressed here and there but nothing so bad that I would want to end my life. Please don’t give up hope... reach out to someone you love and trust, they will help you get through this difficult time. And be patient even if it takes two years. It took me almost two years of suffering to get to where I am now. There is light at the end of the tunnel :) feel free to ask any questions you might have."

8 / 10
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Frequently asked questions

  • Auton...
  • Taken for 2 to 5 years
  • August 12, 2014

For Depression "I relied on these reviews when I first started meds, so wanted to share my experience. I have been on Wellbutrin XL 300mg for about 2.5 years with extremely positive results. This is the first antidepressant I have ever taken, and I have been much better on it. No more falling through emotional thin ice 20+ times a day, no more crying, and hardly any negative thinking. Started on 150xl for about 1.5-2 months then up to 300XL. Experienced almost no side effects -- only a few occasional strange headaches in the beginning Only side effect is constipation, which can mostly be mitigated with fiber and good eating. Exercise is still a must for me to feel O.K. Before, post gym I would go from -6 to 1 or 2. Now with Meds I go from 3/4 to a 9/10"

10 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • April 29, 2016

For Depression "26 year old male. Been on it for 31 days. 1st week 150mg xl: high speedy energy. Mild insomnia (up till 3am most nights). Waking early and generally good mood. 2nd week 300mg xl. Very high constant anxiety. Emotional swings. Broke down in tears one day. 3rd week: Things were smoothing out. Still slightly anxious. Less emotional. 4th week: Feeling completely normal almost like I'm not on any medication. More level headed and better mood with less swings. Anxiety disappearing and confidence growing. No side effects. This is in combination with seeking help from a counselor, and confiding with a close friend of mine about how depressed I have been over the years. I am happy I took it. It has got me back on my feet and allowed me to seek help."

8 / 10
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169 Report

Are you taking this medicine?

  • Lyla...
  • June 17, 2014

For Major Depressive Disorder "I was diagnosed with major depressive disorder in 2006. My depression comes in cycles, but I take this medication every day. I was on Zoloft for about 3 years off and on and gained about 30 pounds, was tired all the time, and had some discouraging sexual side effects to top everything off. I did my research and discovered Wellbutrin, which other people said was more stimulating and had no sexual side effects. I asked my doctor if I could switch and started tapering off Zoloft while starting 150 mgs of Wellbutrin. My doctor upped the dose to 300 mgs and I had never been happier! It has drastically changed my life. Lost weight and can get up in the morning without being a total grouch. I only gave it a 9 because of the cost."

9 / 10
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  • Mama...
  • Taken for less than 1 month
  • March 1, 2014

For Depression "This medicine has saved my life. I was on it for several years (300 mg) and felt it wasn't helping any more so I quit it on my own. No problem quitting but a few months ago began feeling hopeless due to financial problems and could not do anything on weekends but lay around in bed and sleep my weekends away. I couldn't get anything done and put important things off that needed to be done. In just the last 2 days I can tell that I already want to get out of bed and do housework and get a shower. I didn't realize what Wellbutrin XL did for me but I do now and am grateful I am back in it!"

10 / 10
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More FAQ

  • Shels...
  • Taken for 5 to 10 years
  • January 18, 2013

For Depression "I have been on Wellbutrin XL now for almost 7 years and I love it. Before starting Wellbutrin with the other medications I felt tired, could hardly function and could not think clearly, it was so bad I was ready to quit all the meds and just live my life depressed, I mean after all I was sleeping my life away anyway so it didn't matter. So I told my psychiatrist and she put me on Wellbutrin XL it took about 3 weeks to start noticing a big improvement I felt energetic I wanted to do things again my mood has been really good I could concentrate it helped me tremendously in my job and I was able to start living life to the fullest and be that fun loving, energetic person I want to be. I highly recommend this medicine."

10 / 10
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  • AunnieD
  • Taken for 1 to 6 months
  • May 29, 2015

For Depression "I've been on Wellbutrin for 6 months now for anxiety and depression and I feel AMAZING.... I've lost 30lbs and still losing. Not through any actual work on my part. I just find that I'm not as hungry. I'm full of energy every morning and it last all day. I've also noticed an insane increase in Libido and I've easily kicked some bad habits without really trying..... Like biting my nails.... Just doesn't happen anymore. I also don't have any desire for alcohol or cigarettes. For once in my life since starting this long road of anti-depressants, I FINALLY feel like this is the one for me. The only negative side effects I have noticed is my chest/neck stays flush and I really do have to remind myself to eat."

9 / 10
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  • Ydak
  • Taken for 6 months to 1 year
  • October 5, 2023

"Let me start off by saying I'm not a fan of medication... HOWEVER, taking Wellbutrin has forever changed my life. I lived with ADHD and depression but never got treatment until recently. I was fed up with how I was feeling and how it impacted my workflow. I told my psychiatrist that I didn't really want to be on hard medication, so he put me on bupropion. I started off with 150mg and now I'm taking 300mg daily. Let me tell you how life-changing this medication is. I didn't realize I had depression until taking this medication. I feel like a normal person. I can wake up and actually start my day. My sleep has been regular. I don't binge eat or eat out of boredom anymore. I've lost 20 pounds with working out (I gained almost 50lbs post-COVID). This medication has helped me with my sweets and gluten cravings. I think the best part is that I have energy. I have energy to do my laundry, to do the dishes, to live and function like a normal person. I'm very satisfied with this medication."

10 / 10
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  • Honda...
  • July 7, 2021

For Major Depressive Disorder "I am on day 3 of taking 150 MG Wellbutrin XL, extended release. I was previously taking 10 MG Lexapro for 4 years. I found myself constantly fatigued, absolutely no libido and gaining weight. I'm a 44 yr, 145 lb, female. Day one I noticed immediate effect such as a calmness and I wasn't as sad. Keep in mind, I took a month off from no meds at all. I wanted to give my body time to adjust with not having the Lexapro in my system. Day 2 and 3, I noticed my appetite was suppressed. I wasn't as hungry as I was before. I have also been experiencing a slight headache. I am also dealing with insomnia. I think I got maybe 1 hour of sleep the first night, second night, slept better but did wake up and had a hard time falling back to sleep. I will keep you updated and good luck to anyone taking this medication! I have read horror stories with mixing this with alcohol. I haven't tried it and almost scared to have a glass of wine...I'm not a big drinker but I'm scared to have at least 1 or 2 glasses of wine."

9 / 10
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  • Aano
  • Taken for less than 1 month
  • December 20, 2019

For Major Depressive Disorder "I’ve been taking this for a little over 2 weeks now. Before this I was on Zoloft for almost 5 years. 6 years of my life I had constant thoughts of ending it. Ever since I’ve been on this medication I finally want to live. So far I’m having the basic side effects of most anti depressants, loss of appetite (although it is coming back), dry mouth, constipation/stomach pains, and being a bit more sensitive than usual. I would much rather deal with any side effects than wanting to end my life. I’ve read that some side effects will go away within time (since I’m only on my third week)"

9 / 10
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  • Helped...
  • September 19, 2019

For Major Depressive Disorder "I used to have 0 motivation. I could not get out of bed for weeks at a time. I ate whatever food I had and peed in bottles because I couldn’t make the effort go to bathroom; even though bathroom is across from my room! On second day of taking Wellbutrin XL 150mg, I found myself washing my dishes! It surprised me! And it continued to get better from there. Now after about 6 weeks, I’m back in school, working, eating, exercising, meditating, my room is spotless, car is clean, I shower every day and I’m more motivated than I have ever been. A few tips: 1. As helpful as this med is, you can’t just rely on this to help you. You must create healthy lifestyle (eat, exercise, sleep, etc). After all, health comes from healthy living. 2. You might get insomnia and nightmares. To help with insomnia I take 300mg magnesium glycinate and melatonin. It helps but it’s not 100% effective. 3. You won’t get hungry, but remember to eat at least 2,000 calories."

7 / 10
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  • MindyG
  • Taken for less than 1 month
  • April 20, 2023

For Depression "I have battled depression and anhedonia my whole life. I have always tried to manage it through diet, therapy and exercise. I had reached the point where I could find no joy and I was simply existing. Life became incredibly arduous and, quite literally, painful. I had zero interest in any activities, often forcing myself to participate in the things that were expected of me. The only thing that I truly enjoyed was sleeping. I finally saw my doctor and, after a long chat, we settled on Wellbutrin because I really “ wanted to want to do things. “ Fast forward to today, 4 weeks of taking Wellbutrin XL. My life has completely changed for the better. My mood is stable, I have more energy than I ever expected to, my confidence has returned after decades of struggling, I no longer feel sad in social situations and I have become more fit because I am inclined to exercise every day. I am enjoying all of the things that I struggled to get through for so long without side effects."

10 / 10
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  • JosieS
  • Taken for 1 to 6 months
  • August 14, 2023

For Major Depressive Disorder "Before: I've lived with depression for at least 10 years. I've tried Lexapro, Paxil, and Prozac in the past, unfortunately, it left me overall numb. I felt antidepressants weren't for me, so I tried overcoming my depression by changing my lifestyle. For a year, I ate healthier, worked out, and got enough sleep. While my overall health did improve (based on my bloodwork), and I did feel a bit better, my depression was still hovering over me like a cloud. I was still down, had crying spells, snapping at people, bouts of anger, irritable, and just had zero patience. I knew I had to do something when I couldn't even enjoy my vacation at a beautiful resort. Present: My doctor prescribed me Wellbutrin XL 150 mg, and oddly enough, I started to feel better after 3 days. Two weeks in, my husband noticed I was more focused, calmer, happier, and overall uplifted. 2 months in, I feel like a different person. Please give Wellbutrin a try, you have nothing to lose."

10 / 10
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  • Flowe...
  • July 30, 2018

For Major Depressive Disorder "I have struggled with anxiety and depression for years. I’ve tried some other meds and they’ve all made me crazy. I’m usually anti pharma but I have no regrets taking this again. I’m also taking St. John’s wort and I feel like the combo really works for me. My sex drive is back, my motivation is through the roof, I can focus and concentrate again, most of my brain fog has lifted. I wake up and feel a sense of calm. It has also helped with my anxiety. Things don’t bother me much anymore. It doesn’t numb my emotions though. I actually feel excited, joyous, happy, confident. I’m so grateful for Wellbutrin because it’s given me myself back. I’m less angry. I’m less likely to react and fight with my partner. I’m on 300 mg. I highly recommend it but I do know everyone is different and this is just my experience! I wanted to share because of how much it’s benefited my life! I’m a better mom, friend, and partner because of it."

10 / 10
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108 Report
  • Thank...
  • November 8, 2016

For Depression "Ive had mild to severe depression my whole life... i was on Prozac from high school to my early 20's. When I was pregnant with my first child i stop taking my Prozac. A year ago I knew it was time to get back on something because my depression was creeping back in... I spoke to my OB/GYN and she suggested Wellbutin XL and OMG! So grateful that she suggested this... I started with 300mg and now a year and a half later im on 450mgs. And let me be honest.... losing 35lbs because of this medication is a PLUS especially for my depression!"

10 / 10
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  • Steph...
  • April 27, 2015

For Depression "I've been battling moderate anxiety and depression for most of my adult life. I'm 24 now, and since my official diagnosis at age 20 I have tried 4 other medications (Celexa, Zoloft, Paxil, Buspar) and found that each one increased my anxiety, or made me a despondent zombie. 3 months ago my PCP put me on Wellbutrin. Let me tell you, this medication saved my life. I went from spending days lying in bed, smoking weed, having daily panic attacks, to waking up with a desire to take on the day. In the few months since I've been on the medication I've lost 30 pounds. It suppresses the urge to binge eat and provides energy for the gym. My friends said I finally seem like me again. Highly recommended if you hate SSRI's like me!"

9 / 10
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  • Gastr...
  • Taken for 5 to 10 years
  • May 20, 2017

For Depression "This medication is very activating without making me anxious. I take it for depression, but I also have general anxiety disorder, and OCD. I was a little worried about taking it at first because one of the side effects indicated that it could make anxiety worse, but I didn't have that problem at all. It definitely helps with depression and lifting my mood. It's not a "happy pill," but it is good with getting and keeping you going and not letting depression ruin you and keep you from doing what needs to be done and living your life."

10 / 10
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121 Report
  • there...
  • November 14, 2013

For Depression "I've been taking generic Bupropion XL (150mg) for three days and I can already say I feel like a new person. Before, I had no energy. Other than going to work, all I could do was lay around and feel sorry for myself. In just three days I feel more clear-headed, energetic, optimistic... I wish I had started it sooner! The only other medication that's worked for me in the past was adderall, but I couldn't go on taking it due to the many unwanted side effects. Bupropion has worked wonders - little to no side effects for me, other than a slightly increased sex drive and loss of appetite (though nothing compared to adderall in that department). I've also been having really vivid dreams, which I love, since I've never been one to remember them."

9 / 10
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  • JJ - ...
  • Taken for 1 to 6 months
  • December 3, 2016

For Depression "Started out on generic XL 150mg/day taken in am. After 2 weeks, started seeing results; feeling great all day with occasional depression at the end of day. Doc increased to XL 300 mg/day. Big improvement - more energy/motivation, no problem with any side effects except for welcomed weight loss! Dropped 18 lbs in two months. Real easy to diet on this med!"

10 / 10
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  • 21855...
  • Taken for less than 1 month
  • July 4, 2019

For Depression "I would have given this a 10 but I’ve only been on it a week so far. I take one in the morning as it is time released. I am so elated though because for years I’ve been on different medications for depression and anxiety and this one has really improved my quality of life. Even after a week on the others I had side effects and it didn’t seem to help. Hoping this will continue as I feel more alive my appetite and sleeping has improved and my outlook has greatly improved. Of course, eating healthy and exercise and even your spiritual life play into this. I’ve read that different medications help different people and this one is certainly helping me hope the same goes for you have a wonderful day!"

9 / 10
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  • capta...
  • Taken for 1 to 6 months
  • December 30, 2013

For Depression "I have been on this medication for half a year. I was prescribed it for my ADHD and depression. It changed my life completely. As I have never felt so great in my whole life since I was a child. High motivation, increased energy, no suicide thoughts and it helped me to eat less and loose weight! I was on Lexapro for anxiety and panic for 5 years and gained a lot of weight. As well as that I had some other side effects with Lexapro. Happy!"

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  • TAYSMOM
  • May 29, 2010

For ADHD "I am self diagnosed with borderline personality disorder. I have been diagnosed by doctors for PTSD, ADHD, SEVERE depression, and bipolar disorder. I take 1 x 150mg in the morning, but work full time in sales, go to school, and just recently moved in a year ago with the father of my 6 year old. Prior to this medicine, we almost didn't make it. I was angry, jealous, compulsive, impulsive, and could have committed suicide twice in one month. THIS MEDICINE HAS SAVED MY LIFE AND POSSIBLY MY FAMILY. NOTHING ELSE WORKED-- I also take 200mg of generic Lamictal twice a day. I AM ALIVE AGAIN."

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  • JoMar...
  • July 6, 2017

For Depression "Was taking Wellbutrin XL (bupropion) 150mg in AM & Zoloft (sertraline) 150mg at night. There was a miscommunication at my pharmacy so was out of Zoloft over a holiday weekend (3 days). It was the best miscommunication ever! With solely the Wellbutrin XL I have my old self back minus the anxiety & depression. I wake-up refreshed. I have more energy. I'm not napping every day or extremely lethargic. I'm excited to exercise, my libido is back & I'm calm and happy. It also has seemed to help with my food cravings, extra bonus."

9 / 10
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114 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.