Skip to main content

Bupropion / naltrexone and Tiredness: What Users Say (Page 4)

Brand names: Contrave

Reviews for Bupropion / naltrexone

Commonly mentioned side effects
  • Sof...
  • February 2, 2016

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "This is day 5 on Contrave, and the first day I feel a little nausea. I'm still on one pill a day in the morning. I always take it with food to avoid the nausea. I did feel a little tired, but it has really curbed my cravings and snacking, I haven't been eating as much as usual. I started the day I began to PMS because I wanted the cramping all at once, lol, but I didn't experience any cramps at all. I didn't get on the scale for this reason, but I plan to in a week. No constipation, but have blowouts, lol. Will keep updates."

8 / 10
Was this helpful?YesNo
8 Report
  • bla...
  • February 8, 2016

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "Started Contrave 2/4/16. I felt dizzy, tired, headaches. I can't concentrate. I'm hoping it goes away because I spent $200, insurance didn't cover it. I'm 44, weight 209, 5 ft. I need it to work to be healthier."

1 / 10
Was this helpful?YesNo
12 Report
  • hiy...
  • Taken for less than 1 month
  • May 6, 2015

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "Started May 3rd, and the side effects, nausea, tiredness, and lack of energy almost made me stop. I am getting slightly better on day 3, so I'll continue for now. I am diabetic, so I realized I have to eat to keep my blood sugar on an even scale (I wasn't hungry, so I didn't eat). I haven't weighed myself. Starting weight 218 lbs."

6 / 10
Was this helpful?YesNo
8 Report

Frequently asked questions

  • She...
  • Taken for less than 1 month
  • July 3, 2016

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "I have only taken 2 pills, but I am so tired. I just want to sleep all the time. Just feel like a truck hit me, seems like I cannot function. I have to make myself do things. Being on it for 2 days only, I do not want to stop taking it. I seem to have to use the restroom about 1/2 hour after eating, but I feel with that I am getting rid of unwanted waste. I have had no other side effects other than that. I can deal with it if I know that the tiredness will go away. Anyone else have this happen to them? I really would like to know if so."

5 / 10
Was this helpful?YesNo
9 Report
  • Bri...
  • Taken for 6 months to 1 year
  • August 31, 2018

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "I did fine with 1 pill in the AM and 1 in PM, but became extremely ill after increasing to 2 in the AM. The doctor told me to continue another week, but I continued to vomit and have dry heaves. So they told me to just do 1 twice a day. I continued on this for about 6 months and suffered from horrible headaches, constant nausea, lethargy, night sweats, hot flashes, depression, constipation, and the only food I could stomach was French fries and Sprite. I lost about 7 pounds the entire time I used it. I weaned myself off and feel like myself again. Of course, I’ve gained 10 pounds in the 2 months I’ve been off. Not worth the cost or the horrible way I felt while taking it. On a side note, my doctor told me it was safe and I could take it the rest of my life, I do not agree at all. It is a horrible medication."

1 / 10
Was this helpful?YesNo
8 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
  • Lyn...
  • Taken for less than 1 month
  • March 8, 2023

For Weight Loss (Obesity/Overweight) "First day, I felt extremely tired! I have been on 450 of Wellbutrin for 20 years with no issues. 12.5 first day extremely tired and chills. Has anyone else had those symptoms and how long did they last?"

5 / 10
Was this helpful?YesNo
2 Report
  • NWG...
  • Taken for 1 to 6 months
  • June 10, 2016

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "I started taking Contrave for weight loss after the tremendous success of a family member. I'm a 56 y.o. woman, 5'5', 180 lbs. I bike 3x/wk and eat a healthy diet. Desserts are my downfall. The first week on Contrave was great. No side effects, 3 lb weight loss. Week 2, no noticeable weight loss. Week 3, lethargy, slight nausea and headaches, dry mouth, thrush. Kept 3 pills a day for a couple of weeks. I decided to power through the side effects because people reported getting over them. 4 pills a day caused debilitating nausea, extreme lethargy, complete lack of appetite, and migraines. Cut back to 3 pills a day, but was still sick. Finally went to the doctor and gave up completely. Disappointed, but just not for me."

3 / 10
Was this helpful?YesNo
8 Report
  • Hnt...
  • Taken for less than 1 month
  • November 20, 2017

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "Started taking this pill yesterday (11/19/17) and about 2 hours after taking it, felt extremely nauseous and tired. Came home and took a nap. Felt better when I woke up. Definitely noticed a difference in appetite. Wasn't hungry for anything. In the evening, I did recognize the cravings were coming back, but I steered clear of sweets. Woke up today with a horrible headache, not sure if it's related or not, but leery to take Contrave again today because of the headache. Will update later. But so far, it is reducing cravings and can tell when it wears off. I'm sure when I ramp up to pills in the afternoon, it won't wear off."

6 / 10
Was this helpful?YesNo
6 Report
  • Nic...
  • January 3, 2016

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "I have been trying to lose weight since October 2015. Well, long before that, but October was when I became desperate. I suffer from depression, which had made me gain 16 lbs in 2015 alone. I went to my doctor and asked about Contrave after doing extensive research. I was on Wellbutrin for depression, and I felt like it had stopped working, so I opted to go off of it, and that allowed me to start Contrave. I filled my prescription on December 16th. The drug made me tired, but I never woke up tired. I woke up feeling very well rested. Very slight headaches now and then, but nothing horrible. That was the only side effects I have had. It is 1/3/16 now. I went from 216 to 204 lbs today. I'm loving it!"

9 / 10
Was this helpful?YesNo
6 Report
  • Sar...
  • Taken for less than 1 month
  • July 27, 2015

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "I have been on Contrave for 3 weeks now and have lost 7 lbs. I love that the pills control my appetite, but being tired all of the time is outweighing the good of the drug. I am still only taking 2 pills a day, but after the last few days, I plan on discontinuing altogether. I am always sleepy and even to the point of falling asleep when I've had plenty of rest. I have now gotten to the point that I am so tired that it is making me nauseous, and this is not worth it. I have no energy to exercise and no energy to do basic everyday tasks."

4 / 10
Was this helpful?YesNo
7 Report
  • box...
  • August 6, 2017

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "Day 1 on Contrave, I feel dizzy, nauseous, and tired. My heart is beating rapidly, and I am wishing I hadn't started this today. I don't think I can push through these side effects that are supposed to subside. I had been taking Phentermine for the last few months, with great success. My doctor said I can't stay on the Phentermine long term, so we switched to Contrave. Not sure what to do from here about the side effects being so severe."

3 / 10
Was this helpful?YesNo
7 Report
  • Anonymous
  • Taken for less than 1 month
  • December 29, 2015

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "I started Contrave for the first time in July. I have PCOS, and the doctor wanted me to try something that would help me lose the weight I gained from it. This wasn't his first choice, but my insurance wouldn't cover any of the other medications, and it was the only one I could afford out of pocket. I was only on it for three weeks because I was really sick from it. I was nauseated, tired, and it gave me really bad headaches. It became too much, so I decided to stop. I did lose 5 lbs, but I'm not sure if it was from the medicine or from being sick. I started again and am only taking 1 pill. I still have headaches, but I'm not as sick. I would take something else if I could, but I'm doing what I can to have the ability to have kids when I choose."

6 / 10
Was this helpful?YesNo
5 Report
  • Mli...
  • October 1, 2015

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "This drug has not been as effective as I had thought it would be. I did not have any real bad side effects. Some constipation, and at the beginning, I was tired, but after a month or so, I had more energy than usual. I only lost about 4 pounds in 4 months."

5 / 10
Was this helpful?YesNo
7 Report
  • Kev...
  • Taken for less than 1 month
  • June 1, 2017

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "I tolerated the medication very well. It actually was kind of pleasant. However, based on my experience, I would not recommend it. It made me lethargic and seemed to increase my appetite. Sure, I was comfortable, but it was supposed to suppress the appetite, thus lose weight. However, it did reduce the desire to drink a beer or two. It was very good at that!"

3 / 10
Was this helpful?YesNo
4 Report
  • Ton...
  • Taken for less than 1 month
  • March 4, 2018

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "I started taking Contrave in February 2018. I am on week 3, taking 2 pills in the morning and 1 in the evening. The first week I had dry mouth, aggravating headaches, and it seemed like I craved everything. The headaches were not real bad, just enough to aggravate, so I took Tylenol, and that did help. In the second week, I started with diarrhea, very nauseous, and dizzy. My appetite, however, has improved. I feel full all day long, and the cravings have stopped. Now, on week 3, I feel HORRIBLE. I still have the diarrhea, nausea feeling, dizziness, but also very tired and down in the dumps. The past 2 days, all I have wanted to do is lay in bed and sleep. I don’t feel like doing anything and am kind of down in the dumps. I hate feeling like this and don’t know what to do. I don’t know if I need to just continue taking it and see if these side effects stop or just stop taking it altogether. I have lost 3 lbs since taking it, that’s the only good thing. I just don’t know what to do!"

8 / 10
Was this helpful?YesNo
5 Report
  • RN ...
  • Taken for 1 to 6 months
  • October 11, 2017

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "Been taking Contrave for 5 weeks, so just hit the max dose of 2 pills in the AM and 2 pills in the PM a week ago. I've lost 6 pounds. I had some side effects - feeling very foggy and tired for the first 3 to 4 days, but then it cleared up. I still get tired in the mid-afternoon, but nothing I can't handle. I've had to cut back to 2 pills in the AM and 1 pill in the PM due to extremely dry eyes and mouth. The reduction in dose doesn't seem to have impacted the effectiveness of the medication. I had some trepidation about how effective Contrave would be for me because I don't meet the criteria for a binge eater. I'm more of a stress and boredom eater. But I have a reduction in craving even when my favorites are available."

6 / 10
Was this helpful?YesNo
4 Report
  • Sdk...
  • Taken for less than 1 month
  • May 10, 2016

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "I'm on day 3 of this prescription. I'm still unsure of any side effects or effectiveness. I've taken Adipex many different times over the last 5 years. I could always 'feel' when it was working. This definitely doesn't suppress any appetite for me, like the Adipex did. As of now, I don't understand what it does. I'm hoping as I increase the dosage, the medication will begin to help with the weight loss. I have noticed, however, that I am very tired after taking it. I'm also taking 25 mg of Topamax in the morning and 25 mg at night for headaches, as well as 20 mg of Prozac for anxiety. My doctor said they were all okay to take together and that one wouldn't cancel out another. I will update after a month on Contrave."

6 / 10
Was this helpful?YesNo
9 Report
  • MDC...
  • Taken for less than 1 month
  • March 16, 2017

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "I am on the second day of one pill in the am and one in the pm (week 2). No side effects except feeling extremely sleepy. I had been taking 300 mg a day of bupropion prior to starting this, and I thought the tiredness was from having less in my system. From what I see, it may be a side effect of this: drinking coffee to stay awake. Weight was down 3 pounds first week, then got my period, so yesterday it was back up. Dry mouth, especially at night. Will this sleepiness go away???"

5 / 10
Was this helpful?YesNo
4 Report
  • ARW...
  • March 22, 2017

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "I'm only on day 2 of one pill in the morning. I have been loopy, tired, and jittery both days, all day. Dry mouth is manageable, but I was so nervous driving I did not go out today at all. I'm 52, 5'10" and 175 lb with hypertension, high cholesterol, and pre-diabetes. I have a few more days in me, but may have to do this on my own if I can't shake the high feelings."

3 / 10
Was this helpful?YesNo
7 Report
  • awr...
  • July 30, 2015

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "I am a teenager and have lost 5 pounds in two days. I only take Contrave in the morning (because it's my first week, of course). I constantly feel tired and sick, I never feel hungry, and I have to make myself eat. Starting to wonder if this is even safe for me!"

5 / 10
Was this helpful?YesNo
8 Report
  • Nic...
  • December 20, 2015

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "I've only been on Contrave for five days. So far, I've been very tired, but when I sleep, it's a great sleep, and I don't wake up groggy. My doctor weighed me in at 216 lbs, but I had on a hoodie, boots, and I was on my period. I always go up in weight on my period. So I stopped my period two days after starting Contrave, and this morning I weighed in at 207 lbs. Before my period, I had been at 213. So no matter how you look at it, weight has come off. I will update as I go. I gave 9 stars because it has made me drowsy so far, and I haven't noticed any change in my eating habits. I'm a sugar junkie, and that hasn't changed, but I sincerely hope that it does."

9 / 10
Was this helpful?YesNo
5 Report
  • HBa...
  • Taken for 1 to 6 months
  • May 7, 2018

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "I do not recommend this drug to anyone. I was on it for not even 2 months. Yes, I lost a few pounds, but it almost cost me my life. I became more and more depressed while taking this drug. I felt horrible about myself, and I would wake up every morning feeling more tired than when I went to bed. I would get angry over the smallest things. Finally, I reached the lowest of the low. If my husband had not been with me and stopped me, I would not be alive, and he would have lost his wife and our 5 kids would be without their mom. Please do not take this very risky medicine. Being overweight is far better than being dead from a weight loss medication."

1 / 10
Was this helpful?YesNo
4 Report
  • Dis...
  • August 17, 2017

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "I started Contrave 6 weeks ago, and my side effects were I was very angry, easily frustrated, lightheadedness, and headaches. I could not get past the two pills, 1 in the am and 1 in the pm. I started noticing after the third week I became easily frustrated and very angry. I can almost feel the muscles ready to burst out of my skin from the tightness in my neck. So I backed down to just one pill in the am. Then, after two weeks, I increased the dosage. But I have also been very tired after I take the pill. I could sleep all weekend, which is not good for a wife/mother of 3. So I decided to just stop taking Contrave. I've had to take some motion sickness pills to help with side effects."

1 / 10
Was this helpful?YesNo
5 Report
  • nic...
  • Taken for less than 1 month
  • January 12, 2016

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "This medication would have gotten 10 stars if it would give me energy. But I have lost 14 lbs this first month! I still have two days left until the month on it is over, but I am so excited that I wanted to share. I am 5'6", 216 lbs to start and now weigh 202 lbs. Yeah, it's only 14 lbs, but it has been so difficult to get below 206 lbs that I really didn't think that it would happen. I didn't have any side effects other than being tired. I have no idea how this medication worked, but it has. Also, without insurance, I paid $55 after the pharmacy used a prescription savings card (in Louisiana)."

9 / 10
Was this helpful?YesNo
3 Report
  • Aks...
  • June 3, 2017

Bupropion / naltrexone for Weight Loss (Obesity/Overweight) "Just purchased this drug last week, and what a waste of money. I feel very sick and bedridden. I only took two days' worth (2 pills), and I won't be taking it anymore. I cannot function on this drug. I've never been pregnant, but it feels like pregnancy symptoms are described: constantly nauseous, exhausted, and sensitive to smells. I do not recommend this drug."

1 / 10
Was this helpful?YesNo
5 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.