Pylera and Nausea: What Users Say

• Hal...
• Taken for less than 1 month
• July 6, 2021

For Helicobacter Pylori Infection "On my fifth day taking this med. I have all the side effects from nausea to bad stomach spasms, very dry and swollen lips. I can't even see or smell food. I'm taking esomeprazole twice a day. I don't know how I will be able to get through the last 5 days. I feel like I'm going mentally crazy. I live in Syria and we don't have this med here, so I ordered it from France. I was given local meds, but they didn't work, so I got it from France. Even if no one sees my review, typing this is really helping me with my anxiety."

• GSa...
• Taken for less than 1 month
• December 17, 2019

For Helicobacter Pylori Infection "On Pylera for H. pylori, Days 1-3 were okay but days 4-7 were the worst. Loss of appetite, heartburn, acidic reflux, belching (lots of it!), general discomfort, nausea, and vomiting were the worst side effects. Found a way to overcome these: DRINK LOTS OF WATER! Like 2L a day, it'll help out a lot. Recommended food: broth/soup/mashed vegetables, the less solid the better. Try probiotics 15 min before breakfast, so that your intestinal flora stays balanced. Days 8-10 were much better once I drank a lot and ate (semi-)liquid food, I felt almost normal (still acidic reflux in the morning). General discomfort disappeared around day 13. Daily schedule: 9:15 probiotic, 9:30-10:15 breakfast, 12:30-13:15 lunch, 16:30-16:50 snack, 20:00-20:45 dinner. LOTS OF WATER (BUT NO DAIRY) ALL DAY LONG! Don't panic if you're feeling nauseous, stay calm. I tried to meditate and do yoga so that my mind isn't focused on the treatment, it helped psychologically but also physically. Breathe and don't stress yourself!"

• No ...
• August 27, 2019

For Helicobacter Pylori Infection "Due to H. pylori, I had bloating, indigestion, gas, nausea, some change in bowel movements, stomach pain/cramping/gnawing, acid reflux/heartburn, etc. With Pylera, I had terrible nausea and trouble eating, my whole body was very achy, and I felt totally drained while on Pylera. I took some sick leave and teleworked on worst days. I was regimented about taking the medication on time: 7-7:15 am, 12:15-12:30 pm, 5:15-5:30 pm, 10:15-10:30 pm. That definitely helped. I re-tested 1 month later and no longer have H. pylori. After Pylera, I still had burning/gnawing in my stomach, heartburn, bloating, and trapped gas. Damage done by H. pylori can take at least 2-3 months to heal. I went the natural remedy route: 1) acupuncture, 2) Slippery elm, 3) fresh cabbage juice (this was most helpful). I also decided to temporarily remove coffee, alcohol, spicy food, citrus, tomatoes, chocolate, red meat, and dairy from my diet."

• sic...
• October 30, 2014

For Helicobacter Pylori Infection "Had a hard time pretty much since the second day. Some people stated you should eat first. Unfortunately, that makes me want to vomit after taking it. No diarrhea (I took probiotics and ate Activia), but weird stools (very dark and frequent). I think my bowels are empty at this point. Appetite is gone. Lost almost 10 pounds. Difficulty sleeping due to nausea and gas pains. Threw up twice. Little energy. Headaches. Feeling stressed and somewhat depressed at times. Crying bouts in the middle of the night. What I described wasn't constant. It came and went throughout the day, but nights were hardest for some reason. Tomorrow is the final day. Can you survive it? Yes. Is it hard? For sure. If H. pylori is gone, then it's worth it. Be strong."

• dr...
• Taken for less than 1 month
• May 18, 2024

For Helicobacter Pylori Infection "I'm at day 7 of taking this med, and day 6 and 7 were the hardest by far. At the beginning of taking this med, I just had bloating and abdominal pain (manageable) and dark stool, but during day 5, the nausea started, and it became so severe on day 7 that I had to talk to my doctor. The doctor recommended me to take motilinium and to decrease the dosage to 3 times per day instead of 4. Currently, the nausea is kinda better. Wish me luck to push through these bad days. Stay strong."

• Bab...
• July 23, 2019

For Helicobacter Pylori Infection "I'm on day 8 of taking Pylera, and it hasn't been bad, surprisingly. My only complaint is taking so many pills for 10 days can be frustrating and exhausting. I did experience a slight headache and nausea. The nausea didn't start till day 7, but it wasn't bad. Had a headache the first couple of days. I have been fine. It was hard to find things to eat as I did not want to eat anything I was not supposed to. I ate at 7, 12, 4, and 8. Took meds at 10, 2, 6, and 10. Also, I ate very little as there is hardly anything you can eat while taking this. I had trouble finding what to eat, so I hope this helps out for people finding something to eat. I ate hummus, apples, chicken, tuna, eggs, guacamole, spam (all spam is gluten-free)! Gluten-free oatmeal. Duke's mayo is also gluten-free and dairy-free! Mustard is also. Black olives, and I got organic vegetable broth to drink also for my late snack. I drink a 16 oz bottle of water with taking Pylera instead of the 8 oz recommended, and it's all good!"

• Mar...
• Taken for less than 1 month
• May 11, 2025

For Helicobacter Pylori Infection "I went through a Pylera treatment back in February, after 2 courses of antibiotics failing to eradicate the bacteria. Dosage was 3 tablets 4 times a day. Very harsh. Pretty much since the beginning the side effects were really bad. Extreme nausea, vomiting, loss of appetite, diarrhea, dark stools, dark urine, awful taste in my mouth, headaches, and extreme tiredness. I ended up taking 1 week off work. Treatment was for 10 days. After finishing it, nausea started to ease in a couple of days, as well as dark urine and stools. Unfortunately for me, the easiness didn't last long. A few weeks later, I started having these episodes with extreme fatigue, awful nausea, loss of appetite, body aches, especially lower back, weakness, weight loss, and symptoms still going on. I ended up with oral thrush as well. I have been on sick leave for 2 weeks and numerous sick days' notice in between. No matter the amount of GP and hospital appointments, exams, and tests, doctors cannot figure out what's wrong with me."

• Emi...
• September 27, 2018

For Helicobacter Pylori Infection "I had a positive experience with Pylera. As with any other antibiotic, you MUST eat before taking the medication. Moreover, drink water copiously throughout the day and with your meals. The instructions say 8 ounces: double this! Avoid foods that are high in calcium: calcium prevents the medication from working, making you feel worse. This includes ALL dairy but also many replacements like soy milk, etc. Read labels carefully. Unless explicitly told so by your doctor, stop multivitamins/supplements. NO ALCOHOL! Regular intervals will help. Taking the medication right after meals at 7 a.m., noon, 5:30 p.m., and 10 p.m. worked for me. Regularity is key. I took the full course of Pylera and had minimal side effects. I was rigorous about eating and drinking. I was somewhat tired. But I experienced none of the nausea, headaches, etc. that others describe. And I ascribe that to being regimental about the intake of food and water, and timing. Please do not be afraid of Pylera."

• Tum...
• Taken for less than 1 month
• August 29, 2015

For Helicobacter Pylori Infection "Was prescribed this after a positive ID of H. pylori from endoscopy biopsy. 10 days / 12 pills a day. Not gonna lie, it was rough. Side effects included dizziness, upset stomach, nausea for me. Within 10 mins of ingestion, the effects could be felt. I made sure to eat a full meal to help lessen the effects, even at bedtime. Sometimes no effects, other times strong effects. But got through the 10 days. After taking it, still had residual side effects for another 2 days on/off. Then finally, on day 3, returned to normal. Need to do the re-test in 1 mo, so not sure if it worked to kill the bacteria for good. I won't lie, I almost stopped taking it in the middle of treatment but kept telling myself this has to be done and I cannot stop!"

• AIM...
• Taken for less than 1 month
• January 8, 2022

For Helicobacter Pylori Infection "I'm not a big person when it comes to taking a constant medication, but I finished it two weeks ago, and I'm waiting to take the breath test. However, my symptoms have come back. I do not feel good at all. I don't want to go anywhere or do anything. The Zofran hasn't really been helping either. Has anyone else still been feeling sick after taking the medication?"

• Nik...
• Taken for less than 1 month
• May 21, 2014

For Helicobacter Pylori Infection "UPDATE: The Pylera worked! The bacteria have been eradicated! I completed my 10-day treatment on April 7, 2014. The only side effect was some mild nausea (I just ate a little more) and a bad taste in my mouth (lots of sugar-free gum). I am waiting 30 days to test to see if the bug is gone. I will come back on here with the results of the endoscopy."

• Red...
• June 20, 2015

For Helicobacter Pylori Infection "Pylera eradicated my H. Pylori infection. Apparently, I had a horrible case for many years, and this worked. I had tried other drugs in the past, and nothing worked until this. It's rough, though! I think I had every side effect, and the 9th day was the worst, but you have to push through! My tricks - eating larger meals before taking it, and yes, you will always feel bloated and full. Also, sucking on fruit-flavored Tic Tacs helped the nausea. Something I learned - sugar, caffeine, chocolate, and salt feed this bacteria, so I tried to steer clear of these things. I heard vitamin C, grapefruit, and a probiotic keep it away, so I incorporated these into my diet while taking Pylera. I had a pretty aggressive case, but it's gone!!"

• Jos...
• March 14, 2021

For Helicobacter Pylori Infection "In the middle of last month (February), I felt a really bad pain in my belly and was frequently burping. I had nausea, I vomited acid and all. So I was H. pylori positive. My doctor recommended taking Pylera. I felt the war inside my stomach (as Pylera vs H. pylori). On day 4 of treatment, I started feeling the dizziness and awful burning stomach pain accompanied with nausea, feeling sleepy all the time. But please don't quit! It’s worth the fight. Now it’s day 3 after finishing the treatment, I still feel nausea from time to time, but I think it will go away!"

• Cal...
• Taken for less than 1 month
• October 14, 2019

For Helicobacter Pylori Infection "I am on day 7 of this Pylera pill. I really hope it works because I don’t think I can do it again. The headaches, the nausea, the weird taste started after day 4. It’s hard to find things to eat, so if anyone has ideas, please share. Full meals are helpful and lots of water. Fresh fruits, no dairy. It’s very draining, so lots of rest is needed. Glad I found this site. Stay strong."

• Hea...
• September 8, 2018

For Helicobacter Pylori Infection "So I am currently on Pylera for H. pylori. This is Day 8, and I can honestly say this is the worst. The first 5-6 days were fine! I was upbeat, then on day 7, I started feeling pregnant. I can smell everything, I can’t eat anything at all! I have no appetite. I throw up every morning, the nasty metal taste in my mouth, so tired, and feel like I never get any sleep. I don’t know what to do since I have to take the medication after meals, and I can’t eat, and I can’t miss a dose. I have to force myself to eat, but the nausea is horrible. I have mood swings, a fast heart rate.... BASICALLY FEEL LIKE I AM DYING SLOWLY. But I have to stick this through if I want to recover."

• Its...
• September 19, 2019

For Helicobacter Pylori Infection "I've been taking Pylera for 6 days. It's the worst experience I've had with taking this medication. I have all the side effect symptoms. Nausea and the bitter taste are the worst ones. I can't hardly eat, and I've thought about just giving up. This is supposed to be a good medicine, but the side effects will have you second-guessing yourself. I don't think I could make it to day 10. Twelve pills a day are too much meds to take in for anyone. I'm praying that I could get through this. At least they should be able to prescribe you something for nausea. On top of that, I stay sleepy all the time. This med sucks!!"

• Dee...
• July 25, 2021

For Helicobacter Pylori Infection "I wanted to share my experience for those out there feeling anxious about taking this medication. I too read the horror stories and warnings that fill these message boards. Of course, the schedule that you must keep for Pylera is no fun, and there will probably be a few uncomfortable moments of headaches and nausea. But truly, we should thank our lucky stars that we live in a moment of human history with such incredible innovations as antibiotics. I was sick from H. pylori for years. Burning, dyspepsia, tightness in my throat-I was scared that something was really wrong until I was finally diagnosed. It’s been a month since finishing my course of treatment, and although I don’t feel 100% better, the H. pylori is eradicated, and I’m on my way towards healing my stomach. I’m so grateful every day that I committed to getting rid of this malady. These drugs are your ally. Take it! And remember that only a few generations ago, you would have had no choice but to endure H. pylori forever."

• Asi...
• Taken for 1 to 6 months
• February 18, 2016

For Helicobacter Pylori Infection "I finally got rid of H. pylori after completing Pylera in Dec 2015. This was after 2 courses of other antibiotics combo that failed to eradicate it. Before taking Pylera, I had read other reviews that were scary. I promised myself I would come back and review for others in a similar situation. Please make sure you take a really good probiotic (taken at a different time) and ask for an anti-nausea medication to offset/lessen the side effects; it will make taking Pylera much more doable."

• Ghi...
• October 9, 2018

For Helicobacter Pylori Infection "I am 22 years old. I’ve been suffering from Helicobacter pylori for 2 years with severe nausea, gastritis, and bloating. I’ve already taken 2 courses of antibiotics, and the bacteria were still resistant. So I decided not to go to the GI just because I was afraid that the doctor would prescribe me Pylera, which causes side effects, and so I had just been treating the symptoms. Today I finished my 10 days of treatment. For all those who are reading my review, don’t be anxious, it is not that bad at all. Just make sure that you eat before you take the pills. You may have stomach pain - it will go away after taking omeprazole, and you may have nausea, but it can be fixed with what my doctor prescribed me: a medication for nausea (no more nausea after I take it, especially since I’ve been suffering from nausea for 2 years). The only thing that really made me feel uncomfortable is the bad smell of stool. In general, Pylera treatment is not bad at all, just don’t be dramatic. I hope that I got rid of Helicobacter pylori because it really hurts and increases the risk of stomach cancer."

• hyv...
• Taken for less than 1 month
• August 27, 2021

For Helicobacter Pylori Infection "Just gotta say to everyone that we all have different experiences and reactions to medicine, the side effects people talk about shouldn’t scare. I followed through with the antibiotic + omeprazole, 12 a day/2 a day each, making sure to stay hydrated and eat very well before each dose, added natural remedies and probiotics onto the mix as well to surround the bacteria like they do in battle. I went through little to no side effects, the only ones I had were dark stools because the bismuth is strong and makes your stool either dark green or absolute black, a bit of cramps here and there on the first days, and that’s totally normal, minimal cramps mean the antibiotic is doing its job. Tons of water kept the nausea away, double the suggested amount. Fatigue wasn’t so prominent, I only felt very sleepy towards the end of the day. Now I don’t have as much gas, no more diarrhea, I feel refreshed and good."

• Anonymous
• April 6, 2010

For Helicobacter Pylori Infection "I am finishing up my 7th day of the medication. Every website I have read made me extremely nervous about taking this medication. If I can give any advice, eat a full meal before you take the medication! If you don't eat, you will be extremely nauseous and throw up. I hate forcing myself to eat, but if it prevents the nausea, I will do it. You need to eat 4 meals per day. Drink plenty of water all day! The mornings are hard because you do wake up nauseous, but the first thing I do is grab a bottle of water and drink some. I ended up with darkened stool and diarrhea, but other than that everything has been going fine."

• Anonymous
• December 9, 2011

For Helicobacter Pylori Infection "I felt pretty bad for the first couple of days. What really helped me was eating a full meal before each dose. On the dose that you take before bed, I ate a banana, dry toast, and kefir probiotic drink. This really helped me not to feel nauseous in the morning. I also took a probiotic tablet in the morning. I drank a lot of water and chewed gum for the metallic taste. If you stick with it, the medicine will work. My doctor had me continue on the probiotics after finishing these medicines."

• Sai...
• Taken for less than 1 month
• January 26, 2020

For Helicobacter Pylori Infection "I’ve been on Pylera for 10 days. Tonight, I take my last 3 pills. Yes, it’s been so awful. I’m tired, the headaches are awful, and the nausea is horrible. I’ve dealt with H. pylori for the last 14 years. Literally. I’ve taken multiple doses of the PrevPac, but it keeps coming back. I get severe stomach cramps, constant vomiting, diarrhea, headaches, and so on with H. pylori. It’s like having an ongoing flu. Worst of all has been the lightheadedness and being dizzy. I hope like anything that after this it gets rid of the H. pylori. I can deal with 10 days of this if it eliminates the H. pylori. It’s tough, but don’t give up. It’s worth it in the end. Yes, I’ve been irritable because the headaches have been so severe. Hopefully, this works."

• raw...
• May 23, 2015

For Helicobacter Pylori Infection "I wish that I did not take this horrible drug (Pylera). I recently learned that taking raw turmeric would kill the bacteria. During the treatment, I thought I was going to die. I absolutely had no energy. I was dizzy, nauseated, had no appetite. I could not take care of my 3 kids. I could not work. I was in bed and counted down the days to finish the treatment. I was not able to finish the last dosage. Six weeks later, I went in for a breath test and, sure enough, the bacteria was eradicated, but I am left with horrible symptoms. I believe this drug has caused my body to be so weak that my chronic pain has aggravated, and my sensitive stomach has gotten worse. My stomach demands foods every 2-3 hours. I have gained so much weight."

• Km2...
• Taken for less than 1 month
• May 20, 2017

For Helicobacter Pylori Infection "I just wanted to share some positivity on this site. Most of the reviews are scary and disheartening. I will say Pylera is rough. It made me feel worse for a few days, especially around days 5-10. I never was nauseous, really, no vomiting, but I was completely beat. It's a rough medication. Get tons of sleep, rest as much as possible, and drink TONS of water. Eat enough with the doses, too. I haven't had any symptoms at all in 3 days, which is the first time in a year that I can say that!!!! Fingers crossed it sticks. Also, AVOID EMOTIONAL STRESS. Plays a HUGE factor in your well-being and recovery."