Pylera and Loss Of Appetite: What Users Say

• GSa...
• Taken for less than 1 month
• December 17, 2019

For Helicobacter Pylori Infection "On Pylera for H. pylori, Days 1-3 were okay but days 4-7 were the worst. Loss of appetite, heartburn, acidic reflux, belching (lots of it!), general discomfort, nausea, and vomiting were the worst side effects. Found a way to overcome these: DRINK LOTS OF WATER! Like 2L a day, it'll help out a lot. Recommended food: broth/soup/mashed vegetables, the less solid the better. Try probiotics 15 min before breakfast, so that your intestinal flora stays balanced. Days 8-10 were much better once I drank a lot and ate (semi-)liquid food, I felt almost normal (still acidic reflux in the morning). General discomfort disappeared around day 13. Daily schedule: 9:15 probiotic, 9:30-10:15 breakfast, 12:30-13:15 lunch, 16:30-16:50 snack, 20:00-20:45 dinner. LOTS OF WATER (BUT NO DAIRY) ALL DAY LONG! Don't panic if you're feeling nauseous, stay calm. I tried to meditate and do yoga so that my mind isn't focused on the treatment, it helped psychologically but also physically. Breathe and don't stress yourself!"

• No ...
• August 27, 2019

For Helicobacter Pylori Infection "Due to H. pylori, I had bloating, indigestion, gas, nausea, some change in bowel movements, stomach pain/cramping/gnawing, acid reflux/heartburn, etc. With Pylera, I had terrible nausea and trouble eating, my whole body was very achy, and I felt totally drained while on Pylera. I took some sick leave and teleworked on worst days. I was regimented about taking the medication on time: 7-7:15 am, 12:15-12:30 pm, 5:15-5:30 pm, 10:15-10:30 pm. That definitely helped. I re-tested 1 month later and no longer have H. pylori. After Pylera, I still had burning/gnawing in my stomach, heartburn, bloating, and trapped gas. Damage done by H. pylori can take at least 2-3 months to heal. I went the natural remedy route: 1) acupuncture, 2) Slippery elm, 3) fresh cabbage juice (this was most helpful). I also decided to temporarily remove coffee, alcohol, spicy food, citrus, tomatoes, chocolate, red meat, and dairy from my diet."

• sic...
• October 30, 2014

For Helicobacter Pylori Infection "Had a hard time pretty much since the second day. Some people stated you should eat first. Unfortunately, that makes me want to vomit after taking it. No diarrhea (I took probiotics and ate Activia), but weird stools (very dark and frequent). I think my bowels are empty at this point. Appetite is gone. Lost almost 10 pounds. Difficulty sleeping due to nausea and gas pains. Threw up twice. Little energy. Headaches. Feeling stressed and somewhat depressed at times. Crying bouts in the middle of the night. What I described wasn't constant. It came and went throughout the day, but nights were hardest for some reason. Tomorrow is the final day. Can you survive it? Yes. Is it hard? For sure. If H. pylori is gone, then it's worth it. Be strong."

• Mel...
• Taken for less than 1 month
• September 26, 2014

For Helicobacter Pylori Infection "I completed the 10 days of Pylera on September 18. The first few days were not too bad, though like others think, the sheer number of pills each day is inconvenient and overwhelming---especially when you take other meds as well. On or about the 4th day, things changed. I was able to go to work, but the last 6 days were really hard: explosive diarrhea, headaches, bloat, gas, extreme fatigue, irritability, inexplicable crying bouts, and loss of appetite. I felt a bit better the first few days after the medication was finished, but now one week later, I am still experiencing the side effects! I feel worse than when I started the meds. When does it stop? Please share experiences."

• Geo...
• September 11, 2021

For Helicobacter Pylori Infection "I'm back again to tell of my ordeal with Pylera antibiotic. This medication is not a joke. I had all the side effects, the most difficult is loss of appetite and metallic taste in my mouth. I didn't want to even see food or go near it. I was tired and lost weight within 3 days of taking this medication. I had to ignore every social gathering and stay home, cancel all my assignments, and lay in bed helplessly. I thought I would not survive the 10 days. I remember one night I went out in the middle of the night, frustrated and calling the emergency line the doctor gave me. They encouraged me to stay on the course until I finish my last dose yesterday. I feel sorry for everyone who has gone through this, and I wish one day we live without sickness or if there should be an easy way of healing sickness. Please be mentally and physically prepared before taking this medication. I will be doing a breath test in a couple of weeks to see if my sickness is eradicated, speaking from Germany. Thank you."

• raw...
• May 23, 2015

For Helicobacter Pylori Infection "I wish that I did not take this horrible drug (Pylera). I recently learned that taking raw turmeric would kill the bacteria. During the treatment, I thought I was going to die. I absolutely had no energy. I was dizzy, nauseated, had no appetite. I could not take care of my 3 kids. I could not work. I was in bed and counted down the days to finish the treatment. I was not able to finish the last dosage. Six weeks later, I went in for a breath test and, sure enough, the bacteria was eradicated, but I am left with horrible symptoms. I believe this drug has caused my body to be so weak that my chronic pain has aggravated, and my sensitive stomach has gotten worse. My stomach demands foods every 2-3 hours. I have gained so much weight."

• Mr...
• Taken for less than 1 month
• September 3, 2019

For Helicobacter Pylori Infection "Today is my 10th and final day of taking Pylera (thank goodness). It is very powerful stuff and starts killing bacteria immediately! Unfortunately, the good ones too. The first 3 days or so, I had a lot of diarrhea, dizziness, numbness in my extremities, fatigue, and NO appetite. I was only able to eat fruit smoothies, dairy-free yogurt, and broth soups. As a result, I lost almost 15 lb of weight, and not the good kind. I had to call out of work due to my symptoms and lack of energy. Just be cautious if you take this antibiotic and get lots of rest."

• Pau...
• Taken for less than 1 month
• December 19, 2018

For Helicobacter Pylori Infection "I am on day 6 of the treatment, and I have never felt so awful in my entire life. I am very nauseous all the time, my mouth is dry, I have no appetite, but I force myself to eat to combat this feeling. Urine is a very dark amber color, warm sensation in my knees (like standing in front of a heater), tired all the time, could barely get out of bed after sleeping over 10 hours. I am ready to quit. I feel like H. pylori is better than having to deal with the side effects. I am dizzy, can't focus, and when I walk, I feel very wobbly - it was very hard to drive to work, but I have no other option."

• GAA...
• Taken for less than 1 month
• September 9, 2022

For Helicobacter Pylori Infection "H. pylori. (13.00) Pylera 4x3 + omeprazole 2x1 for 10 days. All doses were taken at the same time 6-7 am/12 pm/6 pm/12 am. Days 1-3 were insane. The nausea - exorcism-like!! I cut all the dairy, multivitamins, products high in calcium and iron. No alcohol. No cigarettes or vaping, which as a smoker I had no cravings at all. Pills after meals and with a little bit of food, it helped to ease the nausea slightly. Was afraid it could affect the treatment. I made sure I was not laying down for 10 mins post-pills. Currently day 9, most symptoms became better after day 5. However, then I felt very exhausted mentally and physically and nearly cried every time taking pills, even when symptoms were not as bad as at the beginning. Over the 9 days, I had many changing side effects: nausea, muscle contractions, dark stools, back and chest rash, sweating, lightheadedness, fever, loss of appetite, sadness, sensitivity to noises and light, fatigue, sour taste, and bloating that never went away :/"

• Kel...
• September 17, 2015

For Helicobacter Pylori Infection "Day six. Watery stools. Loss of appetite. Shaky. Brain fritz. Sunburn. (own fault, should have known better) Food tastes odd. Tired and have nausea. Hope this works. My insides sound like two cats fighting in a burlap bag."

• Tan...
• Taken for less than 1 month
• August 16, 2018

For Helicobacter Pylori Infection "I'm just finishing my 10-day protocol, and I am hoping that I never, ever have to take this poison again. Yes... I felt like I was being poisoned with some toxic combo pill pack. It was horrible. I just knew the 'ends justified the means,' so I pushed through. The side effects I experienced were extreme fatigue, headaches/migraines, dark stools, phlegm, blurry vision, body aches, heart palpitations with cough (which I had to go to the ER for because I almost passed out), neck pain, weird taste in mouth, loss of appetite, nausea, and stomach cramping. It's a good thing I don't work, or else I probably would've been fired. I was literally in bed almost the entire time. So, no... uh-uh... not taking this stuff again."

• Anonymous
• June 11, 2017

For Helicobacter Pylori Infection "I am on day 5 and all I can say is I hope this Pylera helps. I've been getting a bad taste in my mouth, insomnia, which makes it so hard to function. Also headaches, stomach pain, extreme fatigue, mood swings, dark stools and urine, loss of appetite, etc. But I am hopeful that this works versus all the other antibiotics I've taken. It seems like a never-ending battle, just about a year now, and getting aggravated with this and being so limited on what to and not to eat to upset me. Hoping for the best. Good luck to all."

• Bel...
• May 19, 2015

For Helicobacter Pylori Infection "Day 3, and these are the symptoms I've experienced: dizziness, anxiety attacks, numbness in toes and fingers, joint pain, nasal congestion, metallic taste in mouth, funny stuffed ear sensation, paresthesia all over, dark stool, low blood sugar if I don't eat every 3 hours, loss of appetite, nausea, brain fog, eye pain, blurred vision, muscle weakness, back pain, malaise, funny feeling in the pit of my stomach, gas, belching, off balance, jaw pain, speech difficulty, irritation, agitation... I am praying that these symptoms will stop today. My doctor told me to tough it out. There must be a better treatment for H. pylori."

• Nmp...
• Taken for less than 1 month
• April 2, 2022

For Helicobacter Pylori Infection "So I finally took my last dose, it was this morning at 1 am. I still feel very tired and nauseous, loss of appetite, but it could also be because I developed oral thrush and had to take fluconazole, so probably all the meds together are not helping the stomach situation. My hardest days were 8-10 because I just could not wait for it to be over. I would say my main issue was I felt weak and tired. I work from home and had to take a day off around my 7th day. I don’t know how they expect people to go in to work, I wouldn’t have been able to. But luckily, I had no vomiting, and I powered through it. Now I’ll update in 1 month if H. pylori is gone!"

• CeC...
• Taken for less than 1 month
• March 28, 2018

For Helicobacter Pylori Infection "Today is my last day taking 14 pills a day (WooHoo!!) and I wish I would have found this post sooner. It's calming to see I'm not alone in all of these side effects. End of Day 1-10: dark/brownish colored urine (really freaked me out!). Day 2-10: metallic taste. Day 3: slight headache. Day 4: slight headache, decreased appetite. Day 5: decreased appetite. Day 6: decreased appetite, dark stool. Day 7: fatigue, dark stool. Day 8: intense headache, fatigue, black stool. Day 9: peripheral neuropathy left leg and foot (again freaked out!), extreme fatigue, black stool. Day 10: numb toes left foot, EXTREME fatigue, black stool. Mucusy off and on throughout (running nose, phlegm, light vaginal discharge)."

• Anonymous
• Taken for less than 1 month
• August 23, 2017

For Helicobacter Pylori Infection "Day 1-2: sweet metallic taste in the mouth after taking the drug. Day 3: sweet metallic taste in the mouth, some extra production of saliva, feeling very tired and sleepy in the 2nd half of the day, reduced appetite. Day 4: feel great in the morning, sweet metallic taste, irritated tongue, excessive production of saliva, mild headache, weakness, black stools multiple times a day and at night, ringing in the ears, reduced appetite. Day 5: sweet metallic taste that doesn't go away, tongue hurts, mild headache, feeling weak and sleepy, black stools many times, ringing in the ears, no appetite, slight dizziness, blurred vision, excessive production of saliva, vomiting several times 15-30 minutes after the 3rd dose, chills, heart palpitations, cramp."

• Anonymous
• Taken for less than 1 month
• August 23, 2017

For Helicobacter Pylori Infection "Day 1-2: sweet metallic taste in the mouth after taking the drug. Day 3: sweet metallic taste in the mouth, some extra production of saliva, feeling very tired and sleepy in the 2nd half of the day, reduced appetite. Day 4: feel great in the morning, sweet metallic taste, irritated tongue, excessive production of saliva, mild headache, weakness, black stools multiple times a day and at night, ringing in the ears, reduced appetite. Day 5: sweet metallic taste that doesn't go away, tongue hurts, mild headache, feeling weak and sleepy, black stools many times, ringing in the ears, no appetite, slight dizziness, blurred vision, excessive production of saliva, vomiting several times 15-30 minutes after the 3rd dose, chills, heart palpitations, cramp."

• Jro...
• August 21, 2017

For Helicobacter Pylori Infection "I'm on day 3, and so far, it hasn't been as bad for me as it has been for others. I have a bad taste in my mouth, lack of appetite, dark stools, and I'm really tired between 1-5 pm. Good luck to everyone else who's in the same boat."

• Kel...
• Taken for less than 1 month
• May 15, 2016

For Helicobacter Pylori Infection "I just finished 10 days. It was really hard. Tested positive for H. pylori after endoscopy, as well as gastritis. No ulcers. Pylera really wrecked my stomach. Side effects for me: metallic taste, nausea, dizziness, acid reflux, lack of appetite, excessive burping, sour stomach, gnawing gut, dark green stools. Recommend asking the doctor for anti-nausea meds, which helped a bit. Did not eat dairy, took probiotics every day. Force-feed yourself plain meals to help with meds. Also took omeprazole twice a day. Hope it gets better - so far, I feel awful!"

• Arr...
• December 26, 2017

For Helicobacter Pylori Infection "I was expecting the worst when I read the reviews here. I even threw away my original prescription due to the reviews here. But symptoms (fatigue for the last 4-5 years, lack of appetite, and occasional nausea) were getting too severe to ignore, so I had to bite the bullet and just go for it. As it turns out, this experience wasn’t nearly as bad as the reviews here. On a scale of 1-10, with 10 being the highest level of discomfort, I’d give this drug a 4. I had some diarrhea, weakness, and moments of nausea. But I never came close to throwing up. I’m not going to say it was easy, but it wasn’t all that bad either. It wasn't anything remotely close to the nightmare scenarios I saw written here. Maybe I’m just lucky?"

• Rey...
• Taken for less than 1 month
• May 11, 2017

For Helicobacter Pylori Infection "It's only the end of day 2, and I am drained! During the day, I don't have any significant side effects except for being really tired and a minor headache. At night, I get a strong sense of nausea and loss of appetite. It's only day 2, good thing I have a doctor appointment in 2 days because an antiemetic is very much needed. Let's hope the next 8 days don't get any worse than what they are."

• Anonymous
• Taken for less than 1 month
• May 19, 2017

For Helicobacter Pylori Infection "40 years young female. I consider myself an average, slightly overweight but generally healthy woman who exercises 3 days a week. Before starting with Pylera and Creon, I read all these reviews about H. pylori bacteria. On meds now, 8th day. Side effects terrible day 1-2, vomiting, uncomfortable, uneasy. Felt everything was dirty, cleaned entire house and laundry. Day 2-4: loss of appetite, extreme bloat, sleepless nights. Terribly tired, everything smells. Mood swings, heart palpitations, stools, dark urine, upset/pain stomach/intestine, bloated, headache, dizziness, weakness. I always had healthy meals: jello and yogurt. I still feel somehow weak, but nothing compared to 1-5. Still can't sleep, and the copper taste is worse, but I have intestinal pain."

• umm...
• Taken for less than 1 month
• October 17, 2022

For Helicobacter Pylori Infection "I finished the 10-day treatment today. I had severe side effects including nausea, diarrhea, dizziness, weakness, shortness of breath, and loss of appetite. The worst side effects showed on days 5 to 10. Sometimes, the dizziness and shortness of breath were so strong that I felt I was dying. But every person has a different reaction. I hope the med works because I don't like to take it again."

• Tou...
• Taken for less than 1 month
• September 15, 2021

For Helicobacter Pylori Infection "I had food poisoning in July 2021, recovered in a week but had persistent diarrhea for some reason (frequent bowel movements, not watery stool). My doc checked for H. pylori and it came back positive. I didn’t have any symptoms, but he said it’s better to treat it. Took Pylera, and I have to say it is a very tough medicine. The first two days were the worst: headache, nausea, neck stiffness, loss of appetite, fatigue, dry mouth, mood swings, feeling like I would die and depressed, the worst feeling ever. Then my body started adapting, and symptoms started to come and go throughout the treatment. Black stool, dark urine, and frequent urination. I just finished it 2 days ago and will check if I still have the bacteria or not. Advice: take with food, avoid dairy and alcohol during treatment, water, and good luck."

• Geo...
• September 5, 2021

For Helicobacter Pylori Infection "I didn't know I had the infection until I went for an endoscopy and the doctor said I have it and prescribed Pylera, 3 caps 4 times daily, and omeprazole, 1 pill twice daily. This is day 5 and the side effects are really bad, I lost weight completely and don't have an appetite for food. I'm weak and feel miserable. Still have 5 days more and hope to go through successfully, please pray for me, and I wish everyone the best..."