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Acetaminophen / chlorpheniramine / phenylephrine User Reviews & Ratings

Brand names: XL-3 Cold Medicine, Norel AD, BC Sinus Pain & Congestion, Allergy Sinus PE Pain Relief, Comtrex Flu Therapy, Tylenol Sinus Congestion and Pain Cool Burst Day Night, HEB Allergy, Contac Cold + Flu (Night Formula), Medicidin-D, ConRx Allergy Sinus, Allergy Pain Relief, PX Allergy Sinus PE, Allergy Multi-Symptom, Pyrroxate, Robitussin Peak Cold Nighttime Nasal Relief, Relief-PE, Onset Forte, GNP Cold Relief Plus, Super Strength Sinadrin, Gendecon, Dristan Cold Multi Symptom Formula, Tylenol Allergy Multi-Symptom, Tylenol Sinus Congestion & Pain Nighttime, Comtrex Severe Cold & Sinus, Tylenol Plus Children's Cold, Hybrid CF Sine-Off Sinus/Cold Dryphen …show all brand names

Acetaminophen / chlorpheniramine / phenylephrine has an average rating of 7.7 out of 10 from a total of 22 reviews on Drugs.com. 74% of reviewers reported a positive experience, while 21% reported a negative experience.

Condition Avg. Rating Reviews Compare
Sinus Symptoms  
8.0
 4 reviews for Sinus Symptoms 340 medications
Cold Symptoms  
7.6
 18 reviews for Cold Symptoms 1122 medications
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Reviews for Acetaminophen / chlorpheniramine / phenylephrine

  • Lmgls
  • January 26, 2016

XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine) for Cold Symptoms "Having a nasty cold with runny nose, sneezing, headache and sore throat; I figured I'd give this a shot. Within 30 minutes of taking 1 pill I was feeling relieved of much of my cold symptoms, however, something just didn't feel right! I started getting extremely nervous, with very high anxiety level. I seriously was freaking out! My heart was pounding like crazy at fast pace and I was all over the place. I felt as though I couldn't calm down and it all seemed to come on suddenly. One minute I was fine and the next I was loosing my self. The side effects seemed to tapper off after about 4 hours( it felt like forever) and by this time I should be in bed sleeping? I don't think that's gonna happen soon?"

3 / 10
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14 Report
  • Jewel
  • October 21, 2018

XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine) for Cold Symptoms "It’s been the best , fast acting cold medication. My family always bought it in Mexico . (Originated from Mexico) But if it’s from Mexico , the ingredients are more potent. Higher mgs. But the US brand works great. It’s best to take after a light meal ,cuts down on the instant “rush feeling “. For night time , I have taken 2 pills (30minutes or 1 hour apart ) knocked me out to get the much needed rest from flu/cold . Always be cautious of medication; everyone reacts differently."

9 / 10
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6 Report
  • Anne...
  • Taken for less than 1 month
  • May 8, 2022

Alka-Seltzer Plus Cold (acetaminophen / chlorpheniramine / phenylephrine) for Cold Symptoms "This is the best cold medication I have ever taken. We found it in Mexico under the name tabcin (Bayer product) but a google search showed that it is the same as Alka Seltzer Plus. No side effects, doesn't make me drowsy or keep me awake, perfect any time of day, and makes me feel great! I don't know why it is not available in the US or Canada."

10 / 10
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1 Report
  • worried...
  • Taken for less than 1 month
  • April 7, 2016

For Cold Symptoms "my 14 year old daughter took two gel tabs for the first time and shortly after became very lethargic. two hours later she experienced a seizure. she had a second seizure a day and a half later. she had no history of seizures previous to this and has not had one since. not sure if it was caused by the meds or simply coincidence. i will never give her that medication again though, that's for sure!"

1 / 10
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1 Report
  • Cold...
  • Taken for 10 years or more
  • February 19, 2024

Pyrroxate (acetaminophen / chlorpheniramine / phenylephrine) for Sinus Symptoms "I was first introduced to Pyrroxate while employed by Ford Motor Company in the 1960s. Working outside in poor weather conditions occasionally led to sinus congestion and head colds, requiring a 'stay at home' period to recover with difficulty sleeping and breathing, along with increased temperature. The clinic at Ford provided a long string of Pyrroxate pills that provided relief from the symptoms, and within a day or two, total relief of the head and sinus running, allowing me to continue working without any side effects. For years, I was able to order this medication from pharmacies and off the shelf from Walmart Pharmacy. I bought several bottles of Pyrroxate and gave them to my daughters with positive results, and they purchased them for their own families after marriage. I haven't been able to find this product in the last 15 years, unfortunately, and have never found a replacement that works as well."

10 / 10
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  • Frank...
  • Taken for 5 to 10 years
  • December 28, 2022

XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine) for Cold Symptoms "The best cold/flu medicine I have used. It definitely helps me get a better night rest. And during the day, it makes me feel a lot better, where I almost forget that I am sick. I just take it when I am really sick and need some help getting through the day. I use this about 3 to 5 times a year. No side effects!"

10 / 10
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  • Dimples
  • Taken for less than 1 month
  • March 28, 2018

Norel AD (acetaminophen / chlorpheniramine / phenylephrine) for Cold Symptoms "I had severe sore throat, mucus draining in the back of my throat. I was given this medication and it worked the same day. I would recommend this to anyone"

9 / 10
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10 Report
  • Lisa...
  • January 9, 2018

XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine) for Cold Symptoms "I tried other medicine with minimal help with XL-3 I felt back to normal. I wake up feeling like death is coming for me, I take XL-3 in 45min I start feeling a LOT better!"

10 / 10
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9 Report
  • martf...
  • April 10, 2010

Alka-Seltzer Plus Cold (acetaminophen / chlorpheniramine / phenylephrine) for Sinus Symptoms "I have been using it for over two decades now and it never fails."

10 / 10
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12 Report
  • Anonymous
  • August 22, 2009

Alka-Seltzer Plus Cold (acetaminophen / chlorpheniramine / phenylephrine) for Cold Symptoms "Good."

9 / 10
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11 Report
  • Anonymous
  • Taken for less than 1 month
  • July 30, 2019

Norel AD (acetaminophen / chlorpheniramine / phenylephrine) for Sinus Symptoms "Does anyone else feels jittery after taking this medication?"

2 / 10
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4 Report
  • Teacher...
  • February 1, 2020

Alka-Seltzer Plus Cold (acetaminophen / chlorpheniramine / phenylephrine) for Cold Symptoms "This stuff makes me so tired I can not get out of bed. It cleared my runny nose and headache, but at a huge cost, I am exhausted!"

9 / 10
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3 Report
  • Allyyyy
  • November 10, 2014

Alka-Seltzer Plus Cold (acetaminophen / chlorpheniramine / phenylephrine) for Cold Symptoms "Lately this medicine has given me stomach pains which are very uncomfortable and I've also had the feeling like I need to use the bathroom"

5 / 10
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5 Report
  • Mr bob
  • Taken for 10 years or more
  • March 19, 2020

Alka-Seltzer Plus Cold (acetaminophen / chlorpheniramine / phenylephrine) for Sinus Symptoms "It works but at a cost. I still feel the side effect and I took it at 6pm it 6am so if you have plans for morning it not the best choose but it does work"

10 / 10
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2 Report
  • Anonymous
  • Taken for 10 years or more
  • January 25, 2022

Alka-Seltzer Plus Cold (acetaminophen / chlorpheniramine / phenylephrine) for Cold Symptoms "I have taken the green and orange gel capsules every time I get cold symptoms. I love the gel capsules. I tried the tablets that you dissolve in water but the capsules work way better in my opinion."

10 / 10
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1 Report
  • kc0tpb
  • Taken for less than 1 month
  • January 8, 2018

For Cold Symptoms "Product works well if you can survive swallowing the pills. Took the medication and got choked, had to have rescue procedures done one me because I couldn't breathe. The pill would not go down."

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2 Report
  • Cater...
  • Taken for 6 months to 1 year
  • October 12, 2017

Alka-Seltzer Plus Cold (acetaminophen / chlorpheniramine / phenylephrine) for Cold Symptoms "This is the best medication for any cold or sinus problems and associated headaches. Easy to use and takes effect quickly."

10 / 10
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2 Report
  • debor
  • November 14, 2009

Pyrroxate (acetaminophen / chlorpheniramine / phenylephrine) for Cold Symptoms "Excellent for drying up runny noses and relieving cough. Makes you really sleepy."

9 / 10
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3 Report
  • Sugar...
  • Taken for 1 to 6 months
  • February 10, 2019

Alka-Seltzer Plus Cold (acetaminophen / chlorpheniramine / phenylephrine) for Cold Symptoms "This product is very effective, but your commercials are extremely goofy. I turn the channel every time one comes on. Bring the Alka Seltzer boy out of retirement."

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1 Report
  • jmano
  • Taken for less than 1 month
  • December 26, 2018

Alka-Seltzer Plus Cold (acetaminophen / chlorpheniramine / phenylephrine) for Cold Symptoms "This caused shortness of breath. I was barely made it to the hospital. This should not be an over the counter medicine"

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  • Deadm...
  • Taken for 2 to 5 years
  • January 2, 2024

XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine) for Cold Symptoms "I've used these for years. They quickly tend to symptoms, so you can sleep and recover. All symptoms gone within 10 minutes."

9 / 10
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  • Joentam
  • Taken for less than 1 month
  • February 14, 2017

For Cold Symptoms "I took this and made me very sick vision problems still after 4 days."

1 / 10
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0 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.